Advanced search
1 file | 2.30 MB Add to list

Scheduled maintenance: Publication downloads temporarily unavailable.

Due to maintenance publication downloads will not be available on:

  • Wednesday, March 27, 17:00 – 21:00
  • Thursday, March 28, 17:00 – 21:00

Exports of lists, FWO and BOF information will remain available.

For any questions, please contact biblio@ugent.be. Apologies for any inconveniences, and thank you for your understanding.

Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives

Author
Organization
Abstract
Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, the structural and functional basis of this organization is still not very clear. Given the heritability of OCD, as suggested by previous family-based studies, we hypothesize that aberrant rich club organization may be a trait marker for OCD. In the present study, 32 patients with OCD, 30 unaffected first-degree relatives (FDR) and 32 healthy controls (HC) underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). We examined the structural rich club organization and its interrelationship with functional coupling. Our results showed that rich club and peripheral connection strength in patients with OCD was lower than in HC, while it was intermediate in FDR. Finally, the coupling between structural and functional connections of the rich club, was decreased in FDR but not in OCD relative to HC, which suggests a buffering mechanism of brain functions in FDR. Overall, our findings suggest that alteration of the rich club organization may reflect a vulnerability biomarker for OCD, possibly buffered by structural and functional coupling of the rich club.
Keywords
Obsessive-compulsive disorder, Vulnerability, Rich club organization, Peripheral connections, Diffusion tensor imaging

Downloads

  • Peng rich club NI-clinical.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 2.30 MB

Citation

Please use this url to cite or link to this publication:

MLA
Peng, Ziwen, et al. “Aberrant Rich Club Organization in Patients with Obsessive-Compulsive Disorder and Their Unaffected First-Degree Relatives.” NEUROIMAGE-CLINICAL, vol. 32, 2021, doi:10.1016/j.nicl.2021.102808.
APA
Peng, Z., Yang, X., Xu, C., Wu, X., Yang, Q., Wei, Z., … Chen, Q. (2021). Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives. NEUROIMAGE-CLINICAL, 32. https://doi.org/10.1016/j.nicl.2021.102808
Chicago author-date
Peng, Ziwen, Xinyi Yang, Chuanyong Xu, Xiangshu Wu, Qiong Yang, Zhen Wei, Zihan Zhou, Tom Verguts, and Qi Chen. 2021. “Aberrant Rich Club Organization in Patients with Obsessive-Compulsive Disorder and Their Unaffected First-Degree Relatives.” NEUROIMAGE-CLINICAL 32. https://doi.org/10.1016/j.nicl.2021.102808.
Chicago author-date (all authors)
Peng, Ziwen, Xinyi Yang, Chuanyong Xu, Xiangshu Wu, Qiong Yang, Zhen Wei, Zihan Zhou, Tom Verguts, and Qi Chen. 2021. “Aberrant Rich Club Organization in Patients with Obsessive-Compulsive Disorder and Their Unaffected First-Degree Relatives.” NEUROIMAGE-CLINICAL 32. doi:10.1016/j.nicl.2021.102808.
Vancouver
1.
Peng Z, Yang X, Xu C, Wu X, Yang Q, Wei Z, et al. Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives. NEUROIMAGE-CLINICAL. 2021;32.
IEEE
[1]
Z. Peng et al., “Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives,” NEUROIMAGE-CLINICAL, vol. 32, 2021.
@article{8725679,
  abstract     = {{Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, the structural and functional basis of this organization is still not very clear. Given the heritability of OCD, as suggested by previous family-based studies, we hypothesize that aberrant rich club organization may be a trait marker for OCD. In the present study, 32 patients with OCD, 30 unaffected first-degree relatives (FDR) and 32 healthy controls (HC) underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). We examined the structural rich club organization and its interrelationship with functional coupling. Our results showed that rich club and peripheral connection strength in patients with OCD was lower than in HC, while it was intermediate in FDR. Finally, the coupling between structural and functional connections of the rich club, was decreased in FDR but not in OCD relative to HC, which suggests a buffering mechanism of brain functions in FDR. Overall, our findings suggest that alteration of the rich club organization may reflect a vulnerability biomarker for OCD, possibly buffered by structural and functional coupling of the rich club.}},
  articleno    = {{102808}},
  author       = {{Peng, Ziwen and Yang, Xinyi and Xu, Chuanyong and Wu, Xiangshu and Yang, Qiong and Wei, Zhen and Zhou, Zihan and Verguts, Tom and Chen, Qi}},
  issn         = {{2213-1582}},
  journal      = {{NEUROIMAGE-CLINICAL}},
  keywords     = {{Obsessive-compulsive disorder,Vulnerability,Rich club organization,Peripheral connections,Diffusion tensor imaging}},
  language     = {{eng}},
  pages        = {{9}},
  title        = {{Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives}},
  url          = {{http://doi.org/10.1016/j.nicl.2021.102808}},
  volume       = {{32}},
  year         = {{2021}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: