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Reduced parasympathetic reactivation during recovery from exercise in myalgic encephalomyelitis/chronic fatigue syndrome

Jessica Van Oosterwijck (UGent) , Uros Marusic, Inge De Wandele (UGent) , Mira Meeus (UGent) , Lorna Paul, Luc Lambrecht, Greta Moorkens, Lieven Danneels (UGent) and Jo Nijs
(2021) JOURNAL OF CLINICAL MEDICINE. 10(19).
Author
Organization
Abstract
Although autonomic nervous system (ANS) dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been proposed, conflicting evidence makes it difficult to draw firm conclusions regarding ANS activity at rest in ME/CFS patients. Although severe exercise intolerance is one of the core features of ME/CFS, little attempts have been made to study ANS responses to physical exercise. Therefore, impairments in ANS activation at rest and following exercise were examined using a case-control study in 20 ME/CFS patients and 20 healthy people. Different autonomous variables, including cardiac, respiratory, and electrodermal responses were assessed at rest and following an acute exercise bout. At rest, parameters in the time-domain represented normal autonomic function in ME/CFS, while frequency-domain parameters indicated the possible presence of diminished (para)sympathetic activation. Reduced parasympathetic reactivation during recovery from exercise was observed in ME/CFS. This is the first study showing reduced parasympathetic reactivation during recovery from physical exercise in ME/CFS. Delayed HR recovery and/or a reduced HRV as seen in ME/CFS have been associated with poor disease prognosis, high risk for adverse cardiac events, and morbidity in other pathologies, implying that future studies should examine whether this is also the case in ME/CFS and how to safely improve HR recovery in this population.
Keywords
General Medicine, autonomic nervous system, autonomic function, electrodermal activity, electrocardiogram, heart rate, HEART-RATE-VARIABILITY, POSTEXERTIONAL MALAISE, RESPONSES, PREDICTOR, PROFILE, POWER, TONE

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MLA
Van Oosterwijck, Jessica, et al. “Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.” JOURNAL OF CLINICAL MEDICINE, vol. 10, no. 19, 2021, doi:10.3390/jcm10194527.
APA
Van Oosterwijck, J., Marusic, U., De Wandele, I., Meeus, M., Paul, L., Lambrecht, L., … Nijs, J. (2021). Reduced parasympathetic reactivation during recovery from exercise in myalgic encephalomyelitis/chronic fatigue syndrome. JOURNAL OF CLINICAL MEDICINE, 10(19). https://doi.org/10.3390/jcm10194527
Chicago author-date
Van Oosterwijck, Jessica, Uros Marusic, Inge De Wandele, Mira Meeus, Lorna Paul, Luc Lambrecht, Greta Moorkens, Lieven Danneels, and Jo Nijs. 2021. “Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.” JOURNAL OF CLINICAL MEDICINE 10 (19). https://doi.org/10.3390/jcm10194527.
Chicago author-date (all authors)
Van Oosterwijck, Jessica, Uros Marusic, Inge De Wandele, Mira Meeus, Lorna Paul, Luc Lambrecht, Greta Moorkens, Lieven Danneels, and Jo Nijs. 2021. “Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.” JOURNAL OF CLINICAL MEDICINE 10 (19). doi:10.3390/jcm10194527.
Vancouver
1.
Van Oosterwijck J, Marusic U, De Wandele I, Meeus M, Paul L, Lambrecht L, et al. Reduced parasympathetic reactivation during recovery from exercise in myalgic encephalomyelitis/chronic fatigue syndrome. JOURNAL OF CLINICAL MEDICINE. 2021;10(19).
IEEE
[1]
J. Van Oosterwijck et al., “Reduced parasympathetic reactivation during recovery from exercise in myalgic encephalomyelitis/chronic fatigue syndrome,” JOURNAL OF CLINICAL MEDICINE, vol. 10, no. 19, 2021.
@article{8725113,
  abstract     = {{Although autonomic nervous system (ANS) dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been proposed, conflicting evidence makes it difficult to draw firm conclusions regarding ANS activity at rest in ME/CFS patients. Although severe exercise intolerance is one of the core features of ME/CFS, little attempts have been made to study ANS responses to physical exercise. Therefore, impairments in ANS activation at rest and following exercise were examined using a case-control study in 20 ME/CFS patients and 20 healthy people. Different autonomous variables, including cardiac, respiratory, and electrodermal responses were assessed at rest and following an acute exercise bout. At rest, parameters in the time-domain represented normal autonomic function in ME/CFS, while frequency-domain parameters indicated the possible presence of diminished (para)sympathetic activation. Reduced parasympathetic reactivation during recovery from exercise was observed in ME/CFS. This is the first study showing reduced parasympathetic reactivation during recovery from physical exercise in ME/CFS. Delayed HR recovery and/or a reduced HRV as seen in ME/CFS have been associated with poor disease prognosis, high risk for adverse cardiac events, and morbidity in other pathologies, implying that future studies should examine whether this is also the case in ME/CFS and how to safely improve HR recovery in this population.}},
  articleno    = {{4527}},
  author       = {{Van Oosterwijck, Jessica and Marusic, Uros and De Wandele, Inge and Meeus, Mira and Paul, Lorna and Lambrecht, Luc and Moorkens, Greta and Danneels, Lieven and Nijs, Jo}},
  issn         = {{2077-0383}},
  journal      = {{JOURNAL OF CLINICAL MEDICINE}},
  keywords     = {{General Medicine,autonomic nervous system,autonomic function,electrodermal activity,electrocardiogram,heart rate,HEART-RATE-VARIABILITY,POSTEXERTIONAL MALAISE,RESPONSES,PREDICTOR,PROFILE,POWER,TONE}},
  language     = {{eng}},
  number       = {{19}},
  pages        = {{19}},
  title        = {{Reduced parasympathetic reactivation during recovery from exercise in myalgic encephalomyelitis/chronic fatigue syndrome}},
  url          = {{http://doi.org/10.3390/jcm10194527}},
  volume       = {{10}},
  year         = {{2021}},
}
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