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Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery

Helena Braet (UGent) , Mohammad Rahimi Gorji (UGent) , Charlotte Debbaut (UGent) , G Ghorbaniasl, Thibault Van Walleghem, Senne Cornelis (UGent) , Sarah Cosyns (UGent) , Chris Vervaet (UGent) , Wouter Willaert (UGent) , Wim Ceelen (UGent) , et al.
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Abstract
Peritoneal metastasis is an advanced cancer type which can be treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Here, chemotherapeutics are nebulized under high pressure in the intraperitoneal (IP) cavity to obtain a better biodistribution and tumor penetration. To prevent the fast leakage of chemotherapeutics from the IP cavity, however, nebulization of controlled release formulations is of interest. In this study, the potential of the thermosensitive hydrogel Pluronic F127 to be applied by high pressure nebulization is evaluated. Therefore, aerosol formation is experimentally examined by laser diffraction and theoretically simulated by computational fluid dynamics (CFD) modelling. Furthermore, Pluronic F127 hydrogels are subjected to rheological characterization after which the release of fluorescent model nanoparticles from the hydrogels is determined. A delicate equilibrium is observed between controlled release properties and suitability for aerosolization, where denser hydrogels (20% and 25% w/v Pluronic F127) are able to sustain nanoparticle release up to 30 h, but cannot effectively be nebulized and vice versa. This is demonstrated by a growing aerosol droplet size and exponentially decreasing aerosol cone angle when Pluronic F127 concentration and viscosity increase. Novel nozzle designs or alternative controlled release formulations could move intraperitoneal drug delivery by high pressure nebulization forward.
Keywords
Hydrogels, Controlled release, Nebulization, PIPAC, Intraperitoneal drug delivery, Computational fluid dynamics, ACID-BASED HYDROGEL, PERITONEAL CARCINOMATOSIS, OVARIAN-CANCER, CHEMOTHERAPY, THERAPY, AEROSOL, NANOPARTICLES, PACLITAXEL, RATIONALE, SYSTEMS

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MLA
Braet, Helena, et al. “Exploring High Pressure Nebulization of Pluronic F127 Hydrogels for Intraperitoneal Drug Delivery.” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 169, 2021, pp. 134–43, doi:10.1016/j.ejpb.2021.10.001.
APA
Braet, H., Rahimi Gorji, M., Debbaut, C., Ghorbaniasl, G., Van Walleghem, T., Cornelis, S., … Remaut, K. (2021). Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 169, 134–143. https://doi.org/10.1016/j.ejpb.2021.10.001
Chicago author-date
Braet, Helena, Mohammad Rahimi Gorji, Charlotte Debbaut, G Ghorbaniasl, Thibault Van Walleghem, Senne Cornelis, Sarah Cosyns, et al. 2021. “Exploring High Pressure Nebulization of Pluronic F127 Hydrogels for Intraperitoneal Drug Delivery.” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 169: 134–43. https://doi.org/10.1016/j.ejpb.2021.10.001.
Chicago author-date (all authors)
Braet, Helena, Mohammad Rahimi Gorji, Charlotte Debbaut, G Ghorbaniasl, Thibault Van Walleghem, Senne Cornelis, Sarah Cosyns, Chris Vervaet, Wouter Willaert, Wim Ceelen, Stefaan De Smedt, and Katrien Remaut. 2021. “Exploring High Pressure Nebulization of Pluronic F127 Hydrogels for Intraperitoneal Drug Delivery.” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 169: 134–143. doi:10.1016/j.ejpb.2021.10.001.
Vancouver
1.
Braet H, Rahimi Gorji M, Debbaut C, Ghorbaniasl G, Van Walleghem T, Cornelis S, et al. Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2021;169:134–43.
IEEE
[1]
H. Braet et al., “Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery,” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 169, pp. 134–143, 2021.
@article{8724971,
  abstract     = {{Peritoneal metastasis is an advanced cancer type which can be treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Here, chemotherapeutics are nebulized under high pressure in the intraperitoneal (IP) cavity to obtain a better biodistribution and tumor penetration. To prevent the fast leakage of chemotherapeutics from the IP cavity, however, nebulization of controlled release formulations is of interest. In this study, the potential of the thermosensitive hydrogel Pluronic F127 to be applied by high pressure nebulization is evaluated. Therefore, aerosol formation is experimentally examined by laser diffraction and theoretically simulated by computational fluid dynamics (CFD) modelling. Furthermore, Pluronic F127 hydrogels are subjected to rheological characterization after which the release of fluorescent model nanoparticles from the hydrogels is determined. A delicate equilibrium is observed between controlled release properties and suitability for aerosolization, where denser hydrogels (20% and 25% w/v Pluronic F127) are able to sustain nanoparticle release up to 30 h, but cannot effectively be nebulized and vice versa. This is demonstrated by a growing aerosol droplet size and exponentially decreasing aerosol cone angle when Pluronic F127 concentration and viscosity increase. Novel nozzle designs or alternative controlled release formulations could move intraperitoneal drug delivery by high pressure nebulization forward.}},
  author       = {{Braet, Helena and Rahimi Gorji, Mohammad and Debbaut, Charlotte and Ghorbaniasl, G and Van Walleghem, Thibault and Cornelis, Senne and Cosyns, Sarah and Vervaet, Chris and Willaert, Wouter and Ceelen, Wim and De Smedt, Stefaan and Remaut, Katrien}},
  issn         = {{0939-6411}},
  journal      = {{EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS}},
  keywords     = {{Hydrogels,Controlled release,Nebulization,PIPAC,Intraperitoneal drug delivery,Computational fluid dynamics,ACID-BASED HYDROGEL,PERITONEAL CARCINOMATOSIS,OVARIAN-CANCER,CHEMOTHERAPY,THERAPY,AEROSOL,NANOPARTICLES,PACLITAXEL,RATIONALE,SYSTEMS}},
  language     = {{eng}},
  pages        = {{134--143}},
  title        = {{Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery}},
  url          = {{http://doi.org/10.1016/j.ejpb.2021.10.001}},
  volume       = {{169}},
  year         = {{2021}},
}

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