Microbial inefficient substrate use through the perspective of resource allocation models
- Author
- Alberte Regueira López (UGent) , Juan M. Lema and Miguel Mauricio-Iglesias
- Organization
- Abstract
- Microorganisms extract energy from substrates following strategies that may seem suboptimal at first glance. Beyond the so-called yield-rate trade-off, resource allocation models, which focus on assigning different functional roles to the limited number of enzymes that a cell can support, offer a framework to interpret the inefficient substrate use by microorganisms. We review here relevant examples of substrate conversions where a significant part of the available energy is not utilised and how resource allocation models offer a mechanistic interpretation thereof, notably for open mixed cultures. Future developments are identified, in particular, the challenge of considering metabolic flexibility towards uncertain environmental changes instead of strict fixed optimality objectives, with the final goal of increasing the prediction capabilities of resource allocation models. Finally, we highlight the relevance of resource allocation to understand and enable a promising biorefinery platform revolving around lactate, which would increase the flexibility of waste-to-chemical biorefinery schemes.
- Keywords
- LACTIC-ACID BACTERIA, ESCHERICHIA-COLI, METABOLIC STRATEGIES, EVOLUTION, GROWTH, POPULATIONS, LABOR
Downloads
-
2021 COBIOT.pdf
- full text (Published version)
- |
- open access
- |
- |
- 682.54 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8724927
- MLA
- Regueira López, Alberte, et al. “Microbial Inefficient Substrate Use through the Perspective of Resource Allocation Models.” CURRENT OPINION IN BIOTECHNOLOGY, vol. 67, 2021, pp. 130–40, doi:10.1016/j.copbio.2021.01.015.
- APA
- Regueira López, A., Lema, J. M., & Mauricio-Iglesias, M. (2021). Microbial inefficient substrate use through the perspective of resource allocation models. CURRENT OPINION IN BIOTECHNOLOGY, 67, 130–140. https://doi.org/10.1016/j.copbio.2021.01.015
- Chicago author-date
- Regueira López, Alberte, Juan M. Lema, and Miguel Mauricio-Iglesias. 2021. “Microbial Inefficient Substrate Use through the Perspective of Resource Allocation Models.” CURRENT OPINION IN BIOTECHNOLOGY 67: 130–40. https://doi.org/10.1016/j.copbio.2021.01.015.
- Chicago author-date (all authors)
- Regueira López, Alberte, Juan M. Lema, and Miguel Mauricio-Iglesias. 2021. “Microbial Inefficient Substrate Use through the Perspective of Resource Allocation Models.” CURRENT OPINION IN BIOTECHNOLOGY 67: 130–140. doi:10.1016/j.copbio.2021.01.015.
- Vancouver
- 1.Regueira López A, Lema JM, Mauricio-Iglesias M. Microbial inefficient substrate use through the perspective of resource allocation models. CURRENT OPINION IN BIOTECHNOLOGY. 2021;67:130–40.
- IEEE
- [1]A. Regueira López, J. M. Lema, and M. Mauricio-Iglesias, “Microbial inefficient substrate use through the perspective of resource allocation models,” CURRENT OPINION IN BIOTECHNOLOGY, vol. 67, pp. 130–140, 2021.
@article{8724927,
abstract = {{Microorganisms extract energy from substrates following strategies that may seem suboptimal at first glance. Beyond the so-called yield-rate trade-off, resource allocation models, which focus on assigning different functional roles to the limited number of enzymes that a cell can support, offer a framework to interpret the inefficient substrate use by microorganisms. We review here relevant examples of substrate conversions where a significant part of the available energy is not utilised and how resource allocation models offer a mechanistic interpretation thereof, notably for open mixed cultures. Future developments are identified, in particular, the challenge of considering metabolic flexibility towards uncertain environmental changes instead of strict fixed optimality objectives, with the final goal of increasing the prediction capabilities of resource allocation models. Finally, we highlight the relevance of resource allocation to understand and enable a promising biorefinery platform revolving around lactate, which would increase the flexibility of waste-to-chemical biorefinery schemes.}},
author = {{Regueira López, Alberte and Lema, Juan M. and Mauricio-Iglesias, Miguel}},
isbn = {{1879-0429}},
issn = {{0958-1669}},
journal = {{CURRENT OPINION IN BIOTECHNOLOGY}},
keywords = {{LACTIC-ACID BACTERIA,ESCHERICHIA-COLI,METABOLIC STRATEGIES,EVOLUTION,GROWTH,POPULATIONS,LABOR}},
language = {{eng}},
pages = {{130--140}},
title = {{Microbial inefficient substrate use through the perspective of resource allocation models}},
url = {{http://dx.doi.org/10.1016/j.copbio.2021.01.015}},
volume = {{67}},
year = {{2021}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: