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Repetitive on-demand drug release from polymeric matrices containing a macroscopic spherical iron core

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Abstract
A system for multiple on-demand drug release has been prepared that can be activated with an alternating magnetic field as external trigger. The core/shell samples have been developed based on a macroscopic spherical iron core coated with a thermoresponsive polymer, poly(styrenestat-butyl methacrylate), containing ibuprofen as a model drug. During exposure of the samples to the magnetic field (ON state), the release rate of ibuprofen is significantly increased, up to 35 times the release rate without the magnetic field (OFF state). Using one sample or two samples in line with the magnetic field does not influence the ON/OFF ratio of the system, showing the possibility of using multiple samples to increase and tune the drug dose. Increasing the concentration of ibuprofen in the polymer layer is shown to increase the release rate in both the ON and OFF states. Increasing the size of the iron core and, consequently, decreasing the polymer thickness, was found to only increase the release rate during exposure resulting in higher ON/OFF ratios. The developed on demand drug delivery systems represents a promising development towards on demand drug delivery implants.
Keywords
STIMULI-RESPONSIVE POLYMER, SENSITIVE HYDROGELS, MAGNETIC-FIELDS, INSULIN RELEASE, DELIVERY, TEMPERATURE, ULTRASOUND, SYSTEMS, MAGNETOLIPOSOMES, NANOPARTICLES

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Citation

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MLA
Rovers, Stefan A., et al. “Repetitive On-Demand Drug Release from Polymeric Matrices Containing a Macroscopic Spherical Iron Core.” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol. 28, no. 10, 2017, doi:10.1007/s10856-017-5983-7.
APA
Rovers, S. A., Kemmere, M. F., Keurentjes, J. T. F., & Hoogenboom, R. (2017). Repetitive on-demand drug release from polymeric matrices containing a macroscopic spherical iron core. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 28(10). https://doi.org/10.1007/s10856-017-5983-7
Chicago author-date
Rovers, Stefan A., Maartje F. Kemmere, Jos T. F. Keurentjes, and Richard Hoogenboom. 2017. “Repetitive On-Demand Drug Release from Polymeric Matrices Containing a Macroscopic Spherical Iron Core.” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 28 (10). https://doi.org/10.1007/s10856-017-5983-7.
Chicago author-date (all authors)
Rovers, Stefan A., Maartje F. Kemmere, Jos T. F. Keurentjes, and Richard Hoogenboom. 2017. “Repetitive On-Demand Drug Release from Polymeric Matrices Containing a Macroscopic Spherical Iron Core.” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 28 (10). doi:10.1007/s10856-017-5983-7.
Vancouver
1.
Rovers SA, Kemmere MF, Keurentjes JTF, Hoogenboom R. Repetitive on-demand drug release from polymeric matrices containing a macroscopic spherical iron core. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 2017;28(10).
IEEE
[1]
S. A. Rovers, M. F. Kemmere, J. T. F. Keurentjes, and R. Hoogenboom, “Repetitive on-demand drug release from polymeric matrices containing a macroscopic spherical iron core,” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol. 28, no. 10, 2017.
@article{8724413,
  abstract     = {{A system for multiple on-demand drug release has been prepared that can be activated with an alternating magnetic field as external trigger. The core/shell samples have been developed based on a macroscopic spherical iron core coated with a thermoresponsive polymer, poly(styrenestat-butyl methacrylate), containing ibuprofen as a model drug. During exposure of the samples to the magnetic field (ON state), the release rate of ibuprofen is significantly increased, up to 35 times the release rate without the magnetic field (OFF state). Using one sample or two samples in line with the magnetic field does not influence the ON/OFF ratio of the system, showing the possibility of using multiple samples to increase and tune the drug dose. Increasing the concentration of ibuprofen in the polymer layer is shown to increase the release rate in both the ON and OFF states. Increasing the size of the iron core and, consequently, decreasing the polymer thickness, was found to only increase the release rate during exposure resulting in higher ON/OFF ratios. The developed on demand drug delivery systems represents a promising development towards on demand drug delivery implants.}},
  articleno    = {{163}},
  author       = {{Rovers, Stefan A. and Kemmere, Maartje F. and Keurentjes, Jos T. F. and Hoogenboom, Richard}},
  issn         = {{0957-4530}},
  journal      = {{JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE}},
  keywords     = {{STIMULI-RESPONSIVE POLYMER,SENSITIVE HYDROGELS,MAGNETIC-FIELDS,INSULIN RELEASE,DELIVERY,TEMPERATURE,ULTRASOUND,SYSTEMS,MAGNETOLIPOSOMES,NANOPARTICLES}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{9}},
  title        = {{Repetitive on-demand drug release from polymeric matrices containing a macroscopic spherical iron core}},
  url          = {{http://doi.org/10.1007/s10856-017-5983-7}},
  volume       = {{28}},
  year         = {{2017}},
}

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