@article{8723252,
  abstract     = {{Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. In this study, we report on resistance profiles of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis and Enterococcus faecium in distinct European geographic regions based on an observational cohort study on intra-abdominal infections in intensive care unit (ICU) patients. Resistance against aminopenicillins, fluoroquinolones, and third-generation cephalosporins in E. coli, K. pneumoniae and P. aeruginosa is problematic, as is carbapenem-resistance in the latter pathogen. For E. coli and K. pneumoniae, resistance is mainly an issue in Central Europe, Eastern and South-East Europe, and Southern Europe, while resistance in P. aeruginosa is additionally problematic in Western Europe. Vancomycin-resistance in E. faecalis is of lesser concern but requires vigilance in E. faecium in Central and Eastern and South-East Europe. In the subcohort of patients with secondary peritonitis presenting with either sepsis or septic shock, the appropriateness of empiric antimicrobial therapy was not associated with mortality. In contrast, failure of source control was strongly associated with mortality. The relevance of these new insights for future recommendations regarding empiric antimicrobial therapy in intra-abdominal infections is discussed.}},
  author       = {{Vogelaers, Dirk and Blot, Stijn and Van den Berge, Andries and Montravers, Philippe and Francois, Guy and Labeau, Sonia and Blot, Koen and Deschepper, Mieke and Antonelli, Massimo and Lipman, Jeffrey and Lamrous, Amin and Pereyra, Cecilia and Lipovestky, Fernando and Koulenti, Despoina and De Waele, Jan and Rezende-Neto, Joao and Cardenas, Yenny and Vymazal, Tomas and Fjeldsoee-Nielsen, Hans and Montravers, Philippe and Kott, Matthias and Kostoula, Arvaniti and Javeri, Yash and Girardis, Massimo and Einav, Sharon and de Lange, Dylan and Makikado, Luis Daniel Umezawa and Mikstacki, Adam and Paiva, José-Artur and Tomescu, Dana and Gritsan, Alexey and Jovanovic, Bojan and Venkatesan, Kumaresh and Mirkovic, Tomislav and Maseda, Emilio and Dikmen, Yalim and Creagh-Brown, Benedict and Lamrous, Amin and Emmerich, Monica and Canale, Mariana and Dietz, Lorena Silvina and Ilutovich, Santiago and Miñope, John Thomas Sanchez and Silva, Ramona Baldomera and Montenegro, Martin Alexis and Martin, Patricio and Saul, Pablo and Chediack, Viviana and Sutton, Giselle and Couce, Rocio and Balasini, Carina and Gonzalez, Susana and Lascar, Florencia Maria and Descotte, Emiliano Jorge and Gumiela, Natalia Soledad and Pino, Carina Alejandra and Cesio, Cristian and Valgolio, Emanuel and Cunto, Eleonora and Dominguez, Cecilia and Lipovestky, Fernando and Nelson, Nydia Funes and Abegao, Esteban Martin and Pereyra, Cecilia and Pozo, Norberto Christian and Bianchi, Luciana and Correger, Enrique and Pastorino, Maria Laura and Miyazaki, Erica Aurora and Pozo, Norberto Christian and Grubissich, Nicolas and Garcia, Mariel and Bonetto, Natalia and Quevedo, Noelia Elizabeth and Gomez, Cristina Delia and Queti, Felipe and Estevarena, Luis Gonzalez and Fernandez, Ruben and Santolaya, Ignacio and Pozo, Norberto Christian and Grangeat, Sergio Hugo and Doglia, Juan and Zakalik, Graciela and Pellegrini, Carlos and Lloria, Maria Monserrat and Chacon, Mercedes Esteban and Fumale, Mariela and Leguizamon, Mariela and Hidalgo, Irene Beatriz and Tiranti, Roberto Julian and Capponi, Paola and Tita, Agustin and Cardonnet, Luis and Bettini, Lisandro and Ramos, Agñel and Lovesio, Luciano and Miranda, Edith Miriam and Farfan, Angelica Beatriz and Tolosa, Carina and Segura, Lise and Bellocchio, Adelina and Alvarez, Brian and Manzur, Adriana and Lujan, Rodolfo and Fernandez, Natalia and Scarone, Nahuel and Zazu, Alan and Groh, Carina and Fletcher, Jason and Smith, Julie and Azad, Raman and Chavan, Nitin and Wong, Helen and Kol, Mark and Campbell, Lewis and Koulenti, Despoina and Starr, Therese and Roberts, Brigit and Wibrow, Bradley and Warhurst, Timothy and Chinthamuneedi, Meher and Ferney, Bernal Buitrago and Simon, Marc and De Backer, Daniel and Wittebole, Xavier and De Bels, David and Collin, Vincent and Dams, Karolien and Jorens, Philippe and Dubois, Jasperina and Gunst, Jan and Haentjens, Lionel and De Schryver, Nicolas and Dugernier, Thierry and Rezende-Neto, Joao and Rizoli, Sandro and Santillan, Paul and Han, Yi and Biskup, Ewelina and Qu, Changjing and Li, Xinyu and Yu, Tao and Weihua, Lu and Molano-Franco, Daniel and Rojas, José and Oviedo, Juan Mauricio Pardo and Pinilla, Dario and Cardenas, Yenny and Celis, Edgar and Arias, Mario and Vukovic, Anita and Vudrag, Maja and Belavic, Matija and Zunic, Josip and Kuharic, Janja and Kricka, Irena Bozanic and Filipovic-Grcic, Ina and Tomasevic, Boris and Obraz, Melanija and Bodulica, Bruna and Dohnal, Martin and Malaska, Jan and Kratochvil, Milan and Satinsky, Igor and Schwarz, Peter and Kos, Zdenek and Blahut, Ladislav and Maca, Jan and Protus, Marek and Kieslichová, Eva and Nielsen, Louise Gramstrup and Krogh, Birgitte Marianne and Rivadeneira, Francisco and Morales, Freddy and Mora, José and Orozco, Alexandra Saraguro and MorochoTutillo, Diego Rolando and Vargas, Nelson Remache and Yepez, Estuardo Salgado and Villamagua, Boris and Alsisi, Adel and Fahmy, Abdelraouf and Dupont, Hervé and Lasocki, Sigismond and Paugam-Burtz, Catherine and Foucrier, Arnaud and Nica, Alexandru and Barjon, Geneviève and Mallat, Jihad and Marcotte, Guillaume and Leone, Marc and Duclos, Gary and Burtin, Philippe and Montravers, Philippe and Atchade, Enora and Mahjoub, Yazine and Misset, Benoît and Timsit, Jean-François and Dupuis, Claire and Veber, Benoît and Debarre, Matthieu and Collange, Oliver and Pottecher, Julien and Hecketsweiler, Stephane and Fromentin, Mélanie and Tesnière, Antoine and Koch, Christian and Sander, Michael and Kott, Matthias and Eckmann, Christian and Elke, Gunnar and Wrigge, Hermann and Simon, Philipp and Chalkiadaki, Anthoula and Tzanidakis, Charalampos and Pneumatikos, Ioannis and Sertaridou, Eleni and Mastora, Zafiria and Pantazopoulos, Ioannis and Papanikolaou, Metaxia and Papavasilopoulou, Theonymfi and Floros, John and Kolonia, Virginia and Dimopoulos, George and Diakaki, Chryssa and Rallis, Michael and Paridou, Alexandra and Kalogeromitros, Alexandros and Romanou, Vasiliki and Nikolaou, Charikleia and Kounougeri, Katerina and Tsigou, Evdoxia and Psallida, Vasiliki and Karampela, Niki and Mandragos, Konstantinos and Kontoudaki, Eftychia and Pentheroudaki, Alexandra and Farazi-Chongouki, Christos and Karakosta, Agathi and Chouris, Isaac and Radu, Vasiliki and Malliotakis, Polychronis and Kokkini, Sofia and Charalambous, Eliana and Kyritsi, Aikaterini and Koulouras, Vasilios and Papathanakos, Georgios and Nagky, Eva and Lampiri, Clairi and Tsimpoukas, Fotios and Sarakatsanos, Ioannis and Georgakopoulos, Panagiotis and Ravani, Ifigeneia and Prekates, Athanasios and Sakellaridis, Konstantinos and Christopoulos, Christos and Vrettou, Efstratia and Stokkos, Konstantinos and Pentari, Anastasia and Arvaniti, Kostoula and Marmanidou, Kyriaki and Kydona, Christina and Tsoumaropoulos, Georgios and Bitzani, Militisa and Kontou, Paschalina and Voudouris, Antonios and Elli-Nikki, [missing] and Flioni, [missing] and Antypa, Elli and Chasou, Eleftheria and Anisoglou, Souzana and Papageorgiou, Eirini and Paraforou, Theoniki and Tsioka, Agoritsa and Karathanou, Antigoni and Vakalos, Aristeidis and Shah, Bhagyesh and Thakkar, Chirag and Jain, Nikhilesh and Gurjar, Mohan and Baronia, Arvind and Sathe, Prachee and Kulkarni, Shilpa and Paul, Cherish and Paul, John and Masjedi, Mansoor and Nikandish, Reza and Zand, Farid and Sabetian, Golnar and Mahmoodpoor, Ata and Hashemian, Seyed Mohammadreza and Bala, Miklosh and Flocco, Romeo and Torrente, Sergio and Pota, Vincenzo and Spadaro, Savino and Volta, Carlo and Girardis, Massimo and Serafini, Giulia and Boraso, Sabrina and Tiberio, Ivo and Cortegiani, Andrea and Misseri, Giovanni and Barbagallo, Maria and Nicolotti, Davide and Forfori, Francesco and Corradi, Francesco and Antonelli, Massimo and De Pascale, Gennaro and Pelagalli, Lorella and Brazzi, Luca and Vittone, Ferdinando Giorgio and Russo, Alessandro and Simion, Davide and Cotoia, Antonella and Cinnella, Gilda and Toppin, Patrick and Johnson-Jackson, Roxanne and Hayashi, Yoshiro and Yamamoto, Ryohei and Yasuda, Hideto and Kishihara, Yuki and Shiotsuka, Junji and Sanchez-Hurtado, Luis Alejandro and Tejeda-Huezo, Brigitte and Gorordo, Luis and Ñamendys-Silva, Silvio A. and Garcia-Guillen, Francisco J. and Martinez, Manuel and Romero-Meja, Erick and Colorado-Dominguez, Ever and van den Oever, Huub and Kalff, Karel Martijn and Vermeijden, Wytze and Cornet, Alexander Daniel and Beck, Oliver and Cimic, Nedim and Dormans, Tom and Bormans, Laura and Bakker, Jan and Van Duijn, Ditty and Bosman, Gerrit and Vos, Piet and de Lange, Dylan and Haas, Lenneke and Henein, Akram and Miranda, Ariel M. and Makikado, Luis Daniel Umezawa and Malca, Gonzalo Ernesto Gianella and Arroyo-Sanchez, Abel and Misiewska-Kaczur, Agnieszka and Akinyi, Frisch and Czuczwar, Miroslaw and Luczak, Karolina and Sulkowski, Wiktor and Tamowicz, Barbara and Mikstacki, Adam and Swit, Beata and Baranowski, Bronisław and Smuszkiewicz, Piotr and Trojanowska, Iwona and Rzymski, Stanislaw and Sawinski, Mariusz and Trosiak, Marta and Mikaszewska-Sokolewicz, Malgorzata and Alves, Ricardo and Leal, Dina and Krystopchuk, Andriy and Mendonca, Pedro Muguel Hilario and Pereira, Rui Antunes and de Carvalho, Maria Raquel Lopes Marques and Candeias, Carlos and Molinos, Elena and Ferreira, Amélia and Castro, Guiomar and Paiva, José-Artur and Pereira, José-Manuel and Santos, Lurdes and Ferreira, Alcina and Pascoalinho, Dulce and Ribeiro, Rosa and Domingos, Guilherme and Gomes, Pedro and Nora, David and Costa, Rui Pedro and Santos, Anabela and Alsheikhly, Ahmed Subhy and Tomescu, Dana and Popescu, Mihai and Grigoras, Ioana and Patrascanu, Emilia and Zabolotskikh, Igor and Musaeva, Tatiana and Gritsan, Alexey and Gaigolnik, Denis and Kulabukhov, Vladimir and Belskiy, Vladislav and Zubareva, Nadezhda and Tribulev, Maxim and Abdelsalam, Ahmed and Aldarsani, Ayman and Al-Khalid, Muhammad and Almekhlafi, Ghaleb and Mandourah, Yasser and Jovanovic, Bojan and Doklestic, Krstina and Velickovic, Jelena and Velickovic, Dejan and Jankovic, Radmilo and Vukovic, Anita and Skoric-Jokic, Svetlana and Radovanovic, Dragana and Richards, Guy and Alli, Ahmad and Del Carmen Cordoba Nielfa, Maria and Iniesta, Rafael Sánchez and Martínez, Adela Benítez-Cano and Bernedo, Carlos Garcia and Gil, Santiago Alberto Picos and Nuvials, Xavier and Rello, Jordi and Garcia, Joseba Gonzalez and Peña, Jose Manuel Garcia and Jimenez, Roberto and Herrera, Luis and Barrachina, Laura Galarza and Monzon, Ignacio Catalan and Redondo, Francisco Javier and Villazala, Ruben and Zapata, Diego Fernando Matallana and Lopez, Isabel Maria Villa and Moreno-Gonzalez, Gabriel and Lopez-Delgado, Juan Carlos and Marin, Jorge Solera and Sanchez-Zamora, Purificacion and Vidal, Montserrat Vallverdú and González, Jesús Flores and Salinas, Irene and Hermosa, Cecilia and Maseda, Emilio and Martinez-Sagasti, Fernando and Domingo-Marín, Sara and Victorino, Johanna Abril and Garcia-Alvarez, Raquel and Calleja, Pablo López-Arcas and de la Torre-Prados, Maria-Victoria and Vidal-Cortes, Pablo and Del Río-Carbajo, Lorena and Izura, Javier and Minguez, Victoria and Alvarez, Josep Trenado and Prous, Anna Parera and Paz, Daniel and Roche-Campo, Ferran and Aguilar, Gerardo and Belda, Javier and Rico-Feijoo, Jesus and Aldecoa, Cesat and Zalba-Etayo, Begoña and Lang, Martin and Dullenkopf, Alexander and Trongtrakul, Konlawij and Chtsomkasem, Anusang and Akbaş, Türkay and Unal, Mustafa Necmettin and Ozcelik, Menekse and Gumus, Ayca and Ramazanoglu, Atilla and Memis, Dilek and Mehmet, Inal and Dikmen, Yalim and Urkmez, Seval and Ozgultekin, Asu and Demirkiran, Oktay and Aslan, Nesrin Ahu and Kizilaslan, Deniz and Kahveci, Ferda and Ünlü, Nurdan and Ozkan, Zeynep and Kaye, Callum and Jansen, Jan and O’Neill, Orla and Nutt, Christopher and Jha, Rajeev and Hooker, Nicolas and Grecu, Irina and Petridou, Christina and Shyamsundar, Murali and McNamee, Lia and Trinder, John and Hagan, Samantha and Kelly, Catriona and Silversides, Jonathon and Groba, Casiano Barrera and Boyd, Owen and Bhowmick, Kaushik and Humphreys, Sally and Summers, Charlotte and Polgarova, Petra and Margarson, Michael and Dickens, Justin and Pearson, Suzanne and Chinery, Elaine and Hemmings, Noel and O’Kane, Sinead and Austin, Pauline and Cole, Stephen and Plowright, Catherine and Box, Roberta and Wright, Christopher and Young, Lorna and Creagh-Brown, Ben and Montague, Laura and Parker, Robert and Morton, Ben and Ostermann, Marlies and Bilinska, Julia and Rose, Bernd Oliver and Reece-Anthony, Rosie and Ryan, Christine and Hamilton, Mark and Hopkins, Philip and Wendon, Julia and Brescia, Giovanni and Ijaz, Nazia and Wood, James and George, Michelle and Toth-Tarsoly, Piroska and Yates, Bryan and Armstrong, Maureen and Scott, Carmen and Boyd, Christine and Szakmany, Tamas and Rees, David and Pulak, Paul and Coggon, Mandy and Saha, Bhaskar and Kent, Linda and Gibson, Bethan and Camsooksai, Julie and Reschreiter, Henrik and Morgan, Pat and Sangaralingham, Sivatharshini and Lowe, Alastair and Vondras, Petr and Jamadarkhana, Sunil and Cruz, Carina and Bhandary, Rakesh and Hersey, Peter and Furneval, Julie and Innes, Richard and Doble, Patricia and Attwood, Ben and Parsons, Penny and Page, Valerie and Zhao, Xiaobei and Grecu, Irina and Dalton, Julian and Hegazy, Mohammed and Awad, Yasser and Naylor, Douglas and Naylor, Amanda and Lee, Sarah and Brevard, Sidney and Davis, Noelle and for the Abdominal Sepsis Study (‘AbSeS’) Group on behalf of the Trials Group of the European Society of Intensive Care Medicine, [missing]}},
  issn         = {{0012-6667}},
  journal      = {{DRUGS}},
  keywords     = {{Pharmacology (medical),BLOOD-STREAM INFECTIONS,ESCHERICHIA-COLI,RISK-FACTORS,FLUOROQUINOLONE RESISTANCE,KLEBSIELLA-PNEUMONIAE,MORTALITY,PERITONITIS,FOOD,ENTEROBACTERIACEAE,PYELONEPHRITIS}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1065--1078}},
  title        = {{Antimicrobial lessons from a large observational cohort on intra-abdominal infections in intensive care units}},
  url          = {{http://doi.org/10.1007/s40265-021-01534-w}},
  volume       = {{81}},
  year         = {{2021}},
}

Altmetric

View in Altmetric

Web of Science

Times cited: