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Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata

Sharon Van Nevel (UGent) , Judith van Ovost (UGent) , Gabriële Holtappels (UGent) , Natalie De Ruyck (UGent) , Nan Zhang (UGent) , Harald Braun (UGent) , Tania Maes (UGent) , Claus Bachert (UGent) and Olga Krysko (UGent)
(2021) FRONTIERS IN IMMUNOLOGY. 12.
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Abstract
Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS). The presence of neutrophils in the airways is often associated with severe airway inflammation, while their precise contribution to the severe inflammation is largely unknown. We aimed to study the role of neutrophils in BALB/c and C57BL/6 mice exposed to Alternaria alternata (Alt). The mice were exposed to Alt extract for twelve hours or ten days to induce allergic airway inflammation. C57BL/6 mice exposed to Alt responded with eosinophilic infiltration and the characteristic IL-5 upregulation. In contrast, the inflammatory response to Alt extract in BALB/c mice was characterized by a neutrophilic response, high levels of G-CSF, and elastase in the lungs. The lack of neutrophils affected the processing of IL-33 in BALB/c mice, as was demonstrated by depletion of neutrophils through intraperitoneal injections of anti-Ly6G antibody. Our data identifies the key role of neutrophils in airway inflammation through IL-33 cleavage in the Alt-induced airway inflammation in mice, which could potentially underline the different endotypes in human disease.
Keywords
Immunology, Immunology and Allergy, allergy, protease, type 2 inflammation, elastase, asthma, SEVERE ASTHMA, INFLAMMATION, EXPRESSION, CHEMOKINES, PROTEASES, DISEASE

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MLA
Van Nevel, Sharon, et al. “Neutrophils Affect IL-33 Processing in Response to the Respiratory Allergen Alternaria Alternata.” FRONTIERS IN IMMUNOLOGY, vol. 12, 2021, doi:10.3389/fimmu.2021.677848.
APA
Van Nevel, S., van Ovost, J., Holtappels, G., De Ruyck, N., Zhang, N., Braun, H., … Krysko, O. (2021). Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata. FRONTIERS IN IMMUNOLOGY, 12. https://doi.org/10.3389/fimmu.2021.677848
Chicago author-date
Van Nevel, Sharon, Judith van Ovost, Gabriële Holtappels, Natalie De Ruyck, Nan Zhang, Harald Braun, Tania Maes, Claus Bachert, and Olga Krysko. 2021. “Neutrophils Affect IL-33 Processing in Response to the Respiratory Allergen Alternaria Alternata.” FRONTIERS IN IMMUNOLOGY 12. https://doi.org/10.3389/fimmu.2021.677848.
Chicago author-date (all authors)
Van Nevel, Sharon, Judith van Ovost, Gabriële Holtappels, Natalie De Ruyck, Nan Zhang, Harald Braun, Tania Maes, Claus Bachert, and Olga Krysko. 2021. “Neutrophils Affect IL-33 Processing in Response to the Respiratory Allergen Alternaria Alternata.” FRONTIERS IN IMMUNOLOGY 12. doi:10.3389/fimmu.2021.677848.
Vancouver
1.
Van Nevel S, van Ovost J, Holtappels G, De Ruyck N, Zhang N, Braun H, et al. Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata. FRONTIERS IN IMMUNOLOGY. 2021;12.
IEEE
[1]
S. Van Nevel et al., “Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata,” FRONTIERS IN IMMUNOLOGY, vol. 12, 2021.
@article{8723159,
  abstract     = {{Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS). The presence of neutrophils in the airways is often associated with severe airway inflammation, while their precise contribution to the severe inflammation is largely unknown. We aimed to study the role of neutrophils in BALB/c and C57BL/6 mice exposed to Alternaria alternata (Alt). The mice were exposed to Alt extract for twelve hours or ten days to induce allergic airway inflammation. C57BL/6 mice exposed to Alt responded with eosinophilic infiltration and the characteristic IL-5 upregulation. In contrast, the inflammatory response to Alt extract in BALB/c mice was characterized by a neutrophilic response, high levels of G-CSF, and elastase in the lungs. The lack of neutrophils affected the processing of IL-33 in BALB/c mice, as was demonstrated by depletion of neutrophils through intraperitoneal injections of anti-Ly6G antibody. Our data identifies the key role of neutrophils in airway inflammation through IL-33 cleavage in the Alt-induced airway inflammation in mice, which could potentially underline the different endotypes in human disease.}},
  articleno    = {{677848}},
  author       = {{Van Nevel, Sharon and van Ovost, Judith and Holtappels, Gabriële and De Ruyck, Natalie and Zhang, Nan and Braun, Harald and Maes, Tania and Bachert, Claus and Krysko, Olga}},
  issn         = {{1664-3224}},
  journal      = {{FRONTIERS IN IMMUNOLOGY}},
  keywords     = {{Immunology,Immunology and Allergy,allergy,protease,type 2 inflammation,elastase,asthma,SEVERE ASTHMA,INFLAMMATION,EXPRESSION,CHEMOKINES,PROTEASES,DISEASE}},
  language     = {{eng}},
  pages        = {{9}},
  title        = {{Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata}},
  url          = {{http://doi.org/10.3389/fimmu.2021.677848}},
  volume       = {{12}},
  year         = {{2021}},
}
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