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ESBL-producing, carbapenem- and ciprofloxacin-resistant Escherichia coli in Belgian and Dutch broiler and pig farms : a cross-sectional and cross-border study

Sien De Koster, Moniek Ringenier (UGent) , Christine Lammens, Arjan Stegeman, Tijs Tobias, Francisca Velkers, Hans Vernooij, Marjolein Kluytmans-van den Bergh, Jan Kluytmans, Jeroen Dewulf (UGent) , et al.
(2021) ANTIBIOTICS-BASEL. 10(8).
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Abstract
Background. The use of antibiotics in food production selects for resistant bacteria and may cause a threat to human and animal health. Belgium and the Netherlands have one of the highest densities of broilers and pigs in Europe, making active monitoring of antibiotic use and resistance in this region vital. Objectives. This study aimed to quantify ESBL-producing (ESBL-E. coli), carbapenem- and ciprofloxacin-resistant (CiproR) Escherichia coli in animal feces on broiler and pig farms with a history of high antibiotic use in Belgium and the Netherlands. Methods. A total of 779 broiler and 817 pig fecal samples, collected from 29 conventional broiler and 31 multiplier pig farms in the cross-border region of Belgium and the Netherlands, were screened for the presence of antibiotic-resistant E. coli using selective culturing. Results. Carbapenem-resistant E. coli were not detected. ESBL-E. coli were remarkably more prevalent in samples from Belgian than Dutch farms. However, CiproR-E. coli were highly prevalent in broilers of both countries. The percentage of samples with ESBL- and CiproR-E. coli was lower in pig compared to poultry farms and varied between farms. No clear association with the on-farm antibiotic use in the year preceding sampling was observed. Multidrug resistance was frequently observed in samples from both countries, but ESBL-production in combination with ciprofloxacin resistance was higher in samples from Belgium. Conclusions. This study demonstrated marked differences in antibiotic resistance between countries, farms and within farms. The observed variation cannot be explained straightforward by prior quantity of antibiotic use suggesting that it results from more complex interactions that warrant further investigation.
Keywords
SPECTRUM-BETA-LACTAMASE, ANTIMICROBIAL RESISTANCE, ANTIBIOTIC-RESISTANCE, ANIMALS, HUMANS, FOOD, DIVERSITY, antibiotic resistance, antibiotic use, Escherichia coli, broilers, pigs

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MLA
De Koster, Sien, et al. “ESBL-Producing, Carbapenem- and Ciprofloxacin-Resistant Escherichia Coli in Belgian and Dutch Broiler and Pig Farms : A Cross-Sectional and Cross-Border Study.” ANTIBIOTICS-BASEL, vol. 10, no. 8, 2021, doi:10.3390/antibiotics10080945.
APA
De Koster, S., Ringenier, M., Lammens, C., Stegeman, A., Tobias, T., Velkers, F., … i-4-1-Health Study Group, for the. (2021). ESBL-producing, carbapenem- and ciprofloxacin-resistant Escherichia coli in Belgian and Dutch broiler and pig farms : a cross-sectional and cross-border study. ANTIBIOTICS-BASEL, 10(8). https://doi.org/10.3390/antibiotics10080945
Chicago author-date
De Koster, Sien, Moniek Ringenier, Christine Lammens, Arjan Stegeman, Tijs Tobias, Francisca Velkers, Hans Vernooij, et al. 2021. “ESBL-Producing, Carbapenem- and Ciprofloxacin-Resistant Escherichia Coli in Belgian and Dutch Broiler and Pig Farms : A Cross-Sectional and Cross-Border Study.” ANTIBIOTICS-BASEL 10 (8). https://doi.org/10.3390/antibiotics10080945.
Chicago author-date (all authors)
De Koster, Sien, Moniek Ringenier, Christine Lammens, Arjan Stegeman, Tijs Tobias, Francisca Velkers, Hans Vernooij, Marjolein Kluytmans-van den Bergh, Jan Kluytmans, Jeroen Dewulf, Herman Goossens, Liselotte Coorevits, Isabel Leroux-Roels, Merel Postma, Pascal De Waegemaeker, and for the i-4-1-Health Study Group. 2021. “ESBL-Producing, Carbapenem- and Ciprofloxacin-Resistant Escherichia Coli in Belgian and Dutch Broiler and Pig Farms : A Cross-Sectional and Cross-Border Study.” ANTIBIOTICS-BASEL 10 (8). doi:10.3390/antibiotics10080945.
Vancouver
1.
De Koster S, Ringenier M, Lammens C, Stegeman A, Tobias T, Velkers F, et al. ESBL-producing, carbapenem- and ciprofloxacin-resistant Escherichia coli in Belgian and Dutch broiler and pig farms : a cross-sectional and cross-border study. ANTIBIOTICS-BASEL. 2021;10(8).
IEEE
[1]
S. De Koster et al., “ESBL-producing, carbapenem- and ciprofloxacin-resistant Escherichia coli in Belgian and Dutch broiler and pig farms : a cross-sectional and cross-border study,” ANTIBIOTICS-BASEL, vol. 10, no. 8, 2021.
@article{8721339,
  abstract     = {{Background. The use of antibiotics in food production selects for resistant bacteria and may cause a threat to human and animal health. Belgium and the Netherlands have one of the highest densities of broilers and pigs in Europe, making active monitoring of antibiotic use and resistance in this region vital. Objectives. This study aimed to quantify ESBL-producing (ESBL-E. coli), carbapenem- and ciprofloxacin-resistant (CiproR) Escherichia coli in animal feces on broiler and pig farms with a history of high antibiotic use in Belgium and the Netherlands. Methods. A total of 779 broiler and 817 pig fecal samples, collected from 29 conventional broiler and 31 multiplier pig farms in the cross-border region of Belgium and the Netherlands, were screened for the presence of antibiotic-resistant E. coli using selective culturing. Results. Carbapenem-resistant E. coli were not detected. ESBL-E. coli were remarkably more prevalent in samples from Belgian than Dutch farms. However, CiproR-E. coli were highly prevalent in broilers of both countries. The percentage of samples with ESBL- and CiproR-E. coli was lower in pig compared to poultry farms and varied between farms. No clear association with the on-farm antibiotic use in the year preceding sampling was observed. Multidrug resistance was frequently observed in samples from both countries, but ESBL-production in combination with ciprofloxacin resistance was higher in samples from Belgium. Conclusions. This study demonstrated marked differences in antibiotic resistance between countries, farms and within farms. The observed variation cannot be explained straightforward by prior quantity of antibiotic use suggesting that it results from more complex interactions that warrant further investigation.}},
  articleno    = {{945}},
  author       = {{De Koster, Sien and Ringenier, Moniek and Lammens, Christine and Stegeman, Arjan and Tobias, Tijs and Velkers, Francisca and Vernooij, Hans and Kluytmans-van den Bergh, Marjolein and Kluytmans, Jan and Dewulf, Jeroen and Goossens, Herman and Coorevits, Liselotte and Leroux-Roels, Isabel and Postma, Merel and De Waegemaeker, Pascal and i-4-1-Health Study Group, for the}},
  issn         = {{2079-6382}},
  journal      = {{ANTIBIOTICS-BASEL}},
  keywords     = {{SPECTRUM-BETA-LACTAMASE,ANTIMICROBIAL RESISTANCE,ANTIBIOTIC-RESISTANCE,ANIMALS,HUMANS,FOOD,DIVERSITY,antibiotic resistance,antibiotic use,Escherichia coli,broilers,pigs}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{14}},
  title        = {{ESBL-producing, carbapenem- and ciprofloxacin-resistant Escherichia coli in Belgian and Dutch broiler and pig farms : a cross-sectional and cross-border study}},
  url          = {{http://doi.org/10.3390/antibiotics10080945}},
  volume       = {{10}},
  year         = {{2021}},
}
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