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Bubble forming films for spatial selective cell killing

Dawei Hua, Aranit Harizaj (UGent) , Mike Wels, Toon Brans (UGent) , Stephan Stremersch (UGent) , Herlinde De Keersmaecker (UGent) , Eduardo Bolea Fernandez (UGent) , Frank Vanhaecke (UGent) , Dimitri Roels (UGent) , Kevin Braeckmans (UGent) , et al.
(2021) ADVANCED MATERIALS. 33(27).
Author
Organization
Abstract
Photodynamic and photothermal cell killing at the surface of tissues finds applications in medicine. However, a lack of control over heat dissipation following a treatment with light might damage surrounding tissues. A new strategy to kill cells at the surface of tissues is reported. Polymeric films are designed in which iron oxide nanoparticles are embedded as photosensitizers. Irradiation of the films with pulsed laser light generates water vapor bubbles at the surface of the films. It is found that "bubble-films" can kill cells in close proximity to the films due to mechanical forces which arise when the bubbles collapse. Local irradiation of bubble-films allows for spatial selective single cell killing. As nanosurgery becomes attractive in ophthalmology to remove superficial tumors, bubble-films are applied on the cornea and found that irradiation of the bubble-films allows spatial and selective killing of corneal cells. As i) the photosensitizer is embedded in the films, which reduces its uptake by cells and spreading into tissues and ii) the bubble-films can be removed from the tissue after laser treatment, while iii) a low laser fluence is sufficient to generate vapor bubbles, it is foreseen that bubble-films might become promising for safe resection of superficial tumors.
Keywords
Mechanical Engineering, Mechanics of Materials, General Materials Science, cornea, nanosurgery, photoablation, photodynamic therapy, single cell killing, CORNEAL EPITHELIUM, GOLD NANOPARTICLES, NANO-THERMOLYSIS, LASER, PHOTOPORATION, DELIVERY, CLUSTERS, THERAPY, MACROMOLECULES, MICROPARTICLES

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Citation

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MLA
Hua, Dawei, et al. “Bubble Forming Films for Spatial Selective Cell Killing.” ADVANCED MATERIALS, vol. 33, no. 27, 2021, doi:10.1002/adma.202008379.
APA
Hua, D., Harizaj, A., Wels, M., Brans, T., Stremersch, S., De Keersmaecker, H., … Sauvage, F. (2021). Bubble forming films for spatial selective cell killing. ADVANCED MATERIALS, 33(27). https://doi.org/10.1002/adma.202008379
Chicago author-date
Hua, Dawei, Aranit Harizaj, Mike Wels, Toon Brans, Stephan Stremersch, Herlinde De Keersmaecker, Eduardo Bolea Fernandez, et al. 2021. “Bubble Forming Films for Spatial Selective Cell Killing.” ADVANCED MATERIALS 33 (27). https://doi.org/10.1002/adma.202008379.
Chicago author-date (all authors)
Hua, Dawei, Aranit Harizaj, Mike Wels, Toon Brans, Stephan Stremersch, Herlinde De Keersmaecker, Eduardo Bolea Fernandez, Frank Vanhaecke, Dimitri Roels, Kevin Braeckmans, Ranhua Xiong, Chaobo Huang, Stefaan De Smedt, and Félix Sauvage. 2021. “Bubble Forming Films for Spatial Selective Cell Killing.” ADVANCED MATERIALS 33 (27). doi:10.1002/adma.202008379.
Vancouver
1.
Hua D, Harizaj A, Wels M, Brans T, Stremersch S, De Keersmaecker H, et al. Bubble forming films for spatial selective cell killing. ADVANCED MATERIALS. 2021;33(27).
IEEE
[1]
D. Hua et al., “Bubble forming films for spatial selective cell killing,” ADVANCED MATERIALS, vol. 33, no. 27, 2021.
@article{8719820,
  abstract     = {{Photodynamic and photothermal cell killing at the surface of tissues finds applications in medicine. However, a lack of control over heat dissipation following a treatment with light might damage surrounding tissues. A new strategy to kill cells at the surface of tissues is reported. Polymeric films are designed in which iron oxide nanoparticles are embedded as photosensitizers. Irradiation of the films with pulsed laser light generates water vapor bubbles at the surface of the films. It is found that "bubble-films" can kill cells in close proximity to the films due to mechanical forces which arise when the bubbles collapse. Local irradiation of bubble-films allows for spatial selective single cell killing. As nanosurgery becomes attractive in ophthalmology to remove superficial tumors, bubble-films are applied on the cornea and found that irradiation of the bubble-films allows spatial and selective killing of corneal cells. As i) the photosensitizer is embedded in the films, which reduces its uptake by cells and spreading into tissues and ii) the bubble-films can be removed from the tissue after laser treatment, while iii) a low laser fluence is sufficient to generate vapor bubbles, it is foreseen that bubble-films might become promising for safe resection of superficial tumors.}},
  articleno    = {{2008379}},
  author       = {{Hua, Dawei and Harizaj, Aranit and Wels, Mike and Brans, Toon and Stremersch, Stephan and De Keersmaecker, Herlinde and Bolea Fernandez, Eduardo and Vanhaecke, Frank and Roels, Dimitri and Braeckmans, Kevin and Xiong, Ranhua and Huang, Chaobo and De Smedt, Stefaan and Sauvage, Félix}},
  issn         = {{0935-9648}},
  journal      = {{ADVANCED MATERIALS}},
  keywords     = {{Mechanical Engineering,Mechanics of Materials,General Materials Science,cornea,nanosurgery,photoablation,photodynamic therapy,single cell killing,CORNEAL EPITHELIUM,GOLD NANOPARTICLES,NANO-THERMOLYSIS,LASER,PHOTOPORATION,DELIVERY,CLUSTERS,THERAPY,MACROMOLECULES,MICROPARTICLES}},
  language     = {{eng}},
  number       = {{27}},
  pages        = {{14}},
  title        = {{Bubble forming films for spatial selective cell killing}},
  url          = {{http://doi.org/10.1002/adma.202008379}},
  volume       = {{33}},
  year         = {{2021}},
}
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