Ghent University Academic Bibliography

Advanced

Intracavitary irradiation of cystic craniopharyngioma by stereotactic instillation of beta-emitting radioisotope (yttrium 90)

Jean-Pierre Kalala Okito UGent, Dirk Van Roost UGent, Ingeborg Goethals UGent, Eric Achten UGent and Jacques Caemaert UGent (2009) Meeting Abstracts 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Joint Meeting with the Benelux countries and Bulgaria. p.219-219
abstract
Objective: Despite the existence of many treatment modalities, successful treatment of craniopharyngioma remains challenging. The radical surgical removal of cystic craniopharyngioma is often hazardous due to the vicinity of critical structures and to the inherent tendency of this pathology to recur. The use of intracystic stereotactic instillation of yttrium in our department is revisited. Methods: Eleven patients harbouring a cystic craniopharyngioma and treated in our department by intracavitary irradiation with yttrium 90 were reviewed. The choice of the radioisotope, the volumetry determination, some technical aspects, and the patients’ evolution are scrutinized. The goal of the treatment was the delivery of a cumulative dose of 200Gy at the inner surface of the cyst wall. Results: Among the 11 patients were 6 males and 5 females. Their mean age was 30.6 years (range 6–65). Six patients were treated with intracavitary irradiation by the time of diagnosis and required no other treatment up to now. In the 5 other cases yttrium instillation was used in conjunction with other treatment modalities (microsurgery, endoscopy, radiotherapy). After yttrium instillation the mean tumour-free evolution time was 18.6 months (range 6–36), and the mean survival was 7.4 years (range 3 m–24 y). Cyst shrinkage of more than 80% (up to disappearance) occurred in 4 cases. In 5 other cases the cyst was reduced by about 50%. In 2 cases it remained “unchanged”. Vision improved in 8 patients, and did not improve in 2 cases. One patient developed a visual field defect (hemianopia) six months after the treatment. There were no complications occurring during the procedure or in the perioperative period. One patient died three months after the procedure from an unrelated reason. Conclusions: Intracavitary stereotactic instillation of Yttrium 90 – although ”old fashioned” – still represents a safe, versatile, long-acting and effective method in the armamentarium of the neurosurgeon against cystic craniopharyngioma. It constitutes a minimally invasive method renewable if necessary.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
intracavitary, yttrium, craniopharyngioma, stereotaxy, irradiation
in
Meeting Abstracts 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Joint Meeting with the Benelux countries and Bulgaria
pages
1 pages
publisher
German Medical Science GMS Publishing House
place of publication
Düsseldorf
conference name
60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Joint Meeting with the Benelux countries and Bulgaria
conference location
Muenster
conference start
2009-05-24
conference end
2009-05-27
language
English
UGent publication?
yes
classification
C3
id
871973
handle
http://hdl.handle.net/1854/LU-871973
alternative location
http://www.egms.de/static/en/meetings/dgnc2009/09dgnc219.shtml
date created
2010-02-20 13:48:18
date last changed
2010-03-01 10:32:37
@inproceedings{871973,
  abstract     = {Objective: Despite the existence of many treatment modalities, successful treatment of craniopharyngioma remains challenging. The radical surgical removal of cystic craniopharyngioma is often hazardous due to the vicinity of critical structures and to the inherent tendency of this pathology to recur. The use of intracystic stereotactic instillation of yttrium in our department is revisited.

Methods: Eleven patients harbouring a cystic craniopharyngioma and treated in our department by intracavitary irradiation with yttrium 90 were reviewed. The choice of the radioisotope, the volumetry determination, some technical aspects, and the patients{\textquoteright} evolution are scrutinized. The goal of the treatment was the delivery of a cumulative dose of 200Gy at the inner surface of the cyst wall.

Results: Among the 11 patients were 6 males and 5 females. Their mean age was 30.6 years (range 6--65). Six patients were treated with intracavitary irradiation by the time of diagnosis and required no other treatment up to now. In the 5 other cases yttrium instillation was used in conjunction with other treatment modalities (microsurgery, endoscopy, radiotherapy). After yttrium instillation the mean tumour-free evolution time was 18.6 months (range 6--36), and the mean survival was 7.4 years (range 3 m--24 y). Cyst shrinkage of more than 80\% (up to disappearance) occurred in 4 cases. In 5 other cases the cyst was reduced by about 50\%. In 2 cases it remained {\textquotedblleft}unchanged{\textquotedblright}. Vision improved in 8 patients, and did not improve in 2 cases. One patient developed a visual field defect (hemianopia) six months after the treatment. There were no complications occurring during the procedure or in the perioperative period. One patient died three months after the procedure from an unrelated reason.

Conclusions: Intracavitary stereotactic instillation of Yttrium 90 -- although {\textquotedblright}old fashioned{\textquotedblright} -- still represents a safe, versatile, long-acting and effective method in the armamentarium of the neurosurgeon against cystic craniopharyngioma. It constitutes a minimally invasive method renewable if necessary.},
  author       = {Kalala Okito, Jean-Pierre and Van Roost, Dirk and Goethals, Ingeborg and Achten, Eric and Caemaert, Jacques},
  booktitle    = {Meeting Abstracts 60. Jahrestagung der Deutschen Gesellschaft f{\"u}r Neurochirurgie (DGNC). Joint Meeting with the Benelux countries and Bulgaria},
  keyword      = {intracavitary,yttrium,craniopharyngioma,stereotaxy,irradiation},
  language     = {eng},
  location     = {Muenster},
  pages        = {219--219},
  publisher    = {German Medical Science GMS Publishing House},
  title        = {Intracavitary irradiation of cystic craniopharyngioma by stereotactic instillation of beta-emitting radioisotope (yttrium 90)},
  url          = {http://www.egms.de/static/en/meetings/dgnc2009/09dgnc219.shtml},
  year         = {2009},
}

Chicago
Kalala Okito, Jean-Pierre, Dirk Van Roost, Ingeborg Goethals, Eric Achten, and Jacques Caemaert. 2009. “Intracavitary Irradiation of Cystic Craniopharyngioma by Stereotactic Instillation of Beta-emitting Radioisotope (yttrium 90).” In Meeting Abstracts 60. Jahrestagung Der Deutschen Gesellschaft Für Neurochirurgie (DGNC). Joint Meeting with the Benelux Countries and Bulgaria, 219–219. Düsseldorf: German Medical Science GMS Publishing House.
APA
Kalala Okito, J.-P., Van Roost, D., Goethals, I., Achten, E., & Caemaert, J. (2009). Intracavitary irradiation of cystic craniopharyngioma by stereotactic instillation of beta-emitting radioisotope (yttrium 90). Meeting Abstracts 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Joint Meeting with the Benelux countries and Bulgaria (pp. 219–219). Presented at the 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Joint Meeting with the Benelux countries and Bulgaria, Düsseldorf: German Medical Science GMS Publishing House.
Vancouver
1.
Kalala Okito J-P, Van Roost D, Goethals I, Achten E, Caemaert J. Intracavitary irradiation of cystic craniopharyngioma by stereotactic instillation of beta-emitting radioisotope (yttrium 90). Meeting Abstracts 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Joint Meeting with the Benelux countries and Bulgaria. Düsseldorf: German Medical Science GMS Publishing House; 2009. p. 219–219.
MLA
Kalala Okito, Jean-Pierre, Dirk Van Roost, Ingeborg Goethals, et al. “Intracavitary Irradiation of Cystic Craniopharyngioma by Stereotactic Instillation of Beta-emitting Radioisotope (yttrium 90).” Meeting Abstracts 60. Jahrestagung Der Deutschen Gesellschaft Für Neurochirurgie (DGNC). Joint Meeting with the Benelux Countries and Bulgaria. Düsseldorf: German Medical Science GMS Publishing House, 2009. 219–219. Print.