Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 1.87 MB
Add to list
  1. Search results
  2. Carbon quantum dots as a dual platfor...

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers : implications for the treatment of eye floaters

Alexandre Barras, Félix Sauvage (UGent) , Inès De Hoon, Kevin Braeckmans (UGent) , Dawei Hua, Gaëtan Buvat, Juan Fraire (UGent) , Christophe Lethien, J. Sebag, Michael Harrington, et al.
(2021) NANOSCALE HORIZONS. 6(6). p.449-461
Author
Organization
Abstract
Common in myopia and aging, vitreous opacities arise from clumped collagen fibers within the vitreous body that cast shadows on the retina, appearing as 'floaters' to the patient. Vitreous opacities degrade contrast sensitivity function and can cause significant impairment in vision-related quality-of-life, representing an unmet and underestimated medical need. One therapeutic approach could be the use of versatile light-responsive nanostructures which (i) interfere with the formation of collagen fibers and/or (ii) destroy aggregates of vitreous collagen upon pulsed-laser irradiation at low fluences. In this work, the potential of positively and negatively charged carbon quantum dots (CQDs) to interfere with the aggregation of type I collagen is investigated. We demonstrate that fibrillation of collagen I is prevented most strongly by positively charged CQDs (CQDs-2) and that pulsed-laser illumination allowed to destroy type I collagen aggregates and vitreous opacities (as obtained from patients after vitrectomy) treated with CQDs-2.

Downloads

  • Download
    Carbon.pdf
    • full text (Accepted manuscript)
    • |
    • open access
    • |
    • PDF
    • |
    • 1.87 MB

Citation

Please use this url to cite or link to this publication:

MLA
Barras, Alexandre, et al. “Carbon Quantum Dots as a Dual Platform for the Inhibition and Light-Based Destruction of Collagen Fibers : Implications for the Treatment of Eye Floaters.” NANOSCALE HORIZONS, vol. 6, no. 6, 2021, pp. 449–61, doi:10.1039/d1nh00157d.
APA
Barras, A., Sauvage, F., De Hoon, I., Braeckmans, K., Hua, D., Buvat, G., … Szunerits, S. (2021). Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers : implications for the treatment of eye floaters. NANOSCALE HORIZONS, 6(6), 449–461. https://doi.org/10.1039/d1nh00157d
Chicago author-date
Barras, Alexandre, Félix Sauvage, Inès De Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan Fraire, et al. 2021. “Carbon Quantum Dots as a Dual Platform for the Inhibition and Light-Based Destruction of Collagen Fibers : Implications for the Treatment of Eye Floaters.” NANOSCALE HORIZONS 6 (6): 449–61. https://doi.org/10.1039/d1nh00157d.
Chicago author-date (all authors)
Barras, Alexandre, Félix Sauvage, Inès De Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan Fraire, Christophe Lethien, J. Sebag, Michael Harrington, Amar Abderrahmani, Rabah Boukherroub, Stefaan De Smedt, and Sabine Szunerits. 2021. “Carbon Quantum Dots as a Dual Platform for the Inhibition and Light-Based Destruction of Collagen Fibers : Implications for the Treatment of Eye Floaters.” NANOSCALE HORIZONS 6 (6): 449–461. doi:10.1039/d1nh00157d.
Vancouver
1.
Barras A, Sauvage F, De Hoon I, Braeckmans K, Hua D, Buvat G, et al. Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers : implications for the treatment of eye floaters. NANOSCALE HORIZONS. 2021;6(6):449–61.
IEEE
[1]
A. Barras et al., “Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers : implications for the treatment of eye floaters,” NANOSCALE HORIZONS, vol. 6, no. 6, pp. 449–461, 2021.
@article{8717013,
  abstract     = {{Common in myopia and aging, vitreous opacities arise from clumped collagen fibers within the vitreous body that cast shadows on the retina, appearing as 'floaters' to the patient. Vitreous opacities degrade contrast sensitivity function and can cause significant impairment in vision-related quality-of-life, representing an unmet and underestimated medical need. One therapeutic approach could be the use of versatile light-responsive nanostructures which (i) interfere with the formation of collagen fibers and/or (ii) destroy aggregates of vitreous collagen upon pulsed-laser irradiation at low fluences. In this work, the potential of positively and negatively charged carbon quantum dots (CQDs) to interfere with the aggregation of type I collagen is investigated. We demonstrate that fibrillation of collagen I is prevented most strongly by positively charged CQDs (CQDs-2) and that pulsed-laser illumination allowed to destroy type I collagen aggregates and vitreous opacities (as obtained from patients after vitrectomy) treated with CQDs-2.}},
  author       = {{Barras, Alexandre and Sauvage, Félix and De Hoon, Inès and Braeckmans, Kevin and Hua, Dawei and Buvat, Gaëtan and Fraire, Juan and Lethien, Christophe and Sebag, J. and Harrington, Michael and Abderrahmani, Amar and Boukherroub, Rabah and De Smedt, Stefaan and Szunerits, Sabine}},
  issn         = {{2055-6756}},
  journal      = {{NANOSCALE HORIZONS}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{449--461}},
  title        = {{Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers : implications for the treatment of eye floaters}},
  url          = {{http://doi.org/10.1039/d1nh00157d}},
  volume       = {{6}},
  year         = {{2021}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: