Human fetal microglia acquire homeostatic immune-sensing properties early in development
- Author
- L. Kracht, M. Borggrewe, S. Eskandar, N. Brouwer, Susana Marina Chuva de Sousa Lopes (UGent) , J. D. Laman, S. A. Scherjon, J. R. Prins, S. M. Kooistra and B. J. L. Eggen
- Organization
- Abstract
- Microglia, immune cells of the central nervous system (CNS), are important for tissue development and maintenance and are implicated in CNS disease, but we lack understanding of human fetal microglia development. Single-cell gene expression and bulk chromatin profiles of microglia at 9 to 18 gestational weeks (GWs) of human fetal development were generated. Microglia were heterogeneous at all studied GWs. Microglia start to mature during this developmental period and increasingly resemble adult microglia with CNS-surveilling properties. Chromatin accessibility increases during development with associated transcriptional networks reflective of adult microglia. Thus, during early fetal development, microglia progress toward a more mature, immune-sensing competent phenotype, and this might render the developing human CNS vulnerable to environmental perturbations during early pregnancy.
- Keywords
- READ ALIGNMENT, RNA-SEQ, DIFFERENTIATION, MYELINOGENESIS, TURNOVER, BINDING, CELLS, PU.1, AGE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8716254
- MLA
- Kracht, L., et al. “Human Fetal Microglia Acquire Homeostatic Immune-Sensing Properties Early in Development.” SCIENCE, vol. 369, no. 6503, 2020, pp. 530–37, doi:10.1126/science.aba5906.
- APA
- Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Chuva de Sousa Lopes, S. M., Laman, J. D., … Eggen, B. J. L. (2020). Human fetal microglia acquire homeostatic immune-sensing properties early in development. SCIENCE, 369(6503), 530–537. https://doi.org/10.1126/science.aba5906
- Chicago author-date
- Kracht, L., M. Borggrewe, S. Eskandar, N. Brouwer, Susana Marina Chuva de Sousa Lopes, J. D. Laman, S. A. Scherjon, J. R. Prins, S. M. Kooistra, and B. J. L. Eggen. 2020. “Human Fetal Microglia Acquire Homeostatic Immune-Sensing Properties Early in Development.” SCIENCE 369 (6503): 530–37. https://doi.org/10.1126/science.aba5906.
- Chicago author-date (all authors)
- Kracht, L., M. Borggrewe, S. Eskandar, N. Brouwer, Susana Marina Chuva de Sousa Lopes, J. D. Laman, S. A. Scherjon, J. R. Prins, S. M. Kooistra, and B. J. L. Eggen. 2020. “Human Fetal Microglia Acquire Homeostatic Immune-Sensing Properties Early in Development.” SCIENCE 369 (6503): 530–537. doi:10.1126/science.aba5906.
- Vancouver
- 1.Kracht L, Borggrewe M, Eskandar S, Brouwer N, Chuva de Sousa Lopes SM, Laman JD, et al. Human fetal microglia acquire homeostatic immune-sensing properties early in development. SCIENCE. 2020;369(6503):530–7.
- IEEE
- [1]L. Kracht et al., “Human fetal microglia acquire homeostatic immune-sensing properties early in development,” SCIENCE, vol. 369, no. 6503, pp. 530–537, 2020.
@article{8716254, abstract = {{Microglia, immune cells of the central nervous system (CNS), are important for tissue development and maintenance and are implicated in CNS disease, but we lack understanding of human fetal microglia development. Single-cell gene expression and bulk chromatin profiles of microglia at 9 to 18 gestational weeks (GWs) of human fetal development were generated. Microglia were heterogeneous at all studied GWs. Microglia start to mature during this developmental period and increasingly resemble adult microglia with CNS-surveilling properties. Chromatin accessibility increases during development with associated transcriptional networks reflective of adult microglia. Thus, during early fetal development, microglia progress toward a more mature, immune-sensing competent phenotype, and this might render the developing human CNS vulnerable to environmental perturbations during early pregnancy.}}, author = {{Kracht, L. and Borggrewe, M. and Eskandar, S. and Brouwer, N. and Chuva de Sousa Lopes, Susana Marina and Laman, J. D. and Scherjon, S. A. and Prins, J. R. and Kooistra, S. M. and Eggen, B. J. L.}}, issn = {{0036-8075}}, journal = {{SCIENCE}}, keywords = {{READ ALIGNMENT,RNA-SEQ,DIFFERENTIATION,MYELINOGENESIS,TURNOVER,BINDING,CELLS,PU.1,AGE}}, language = {{eng}}, number = {{6503}}, pages = {{530--537}}, title = {{Human fetal microglia acquire homeostatic immune-sensing properties early in development}}, url = {{http://doi.org/10.1126/science.aba5906}}, volume = {{369}}, year = {{2020}}, }
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