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Controlling the shape and chirality of an eight-crossing molecular knot

(2021) CHEM. 7(6). p.1534-1543
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Abstract
The knotting of biomolecules impacts their function and enables them to carry out new tasks. Likewise, complex topologies underpin the operation of many synthetic molecular machines. The ability to generate and control more complex architectures is essential to endow these machines with more advanced functions. Here, we report the synthesis of a molecular knot with eight crossing points, consisting of a single organic loop woven about six templating metal centers, via one-pot self-assembly from a pair of simple dialdehyde and diamine subcomponents and a single metal salt. The structure and topology of the knot were established by NMR spectroscopy, mass spectrometry, and X-ray crystallography. Upon demetallation, the purely organic strand relaxes into a symmetric conformation, while retaining the topology of the original knot. This knot is topologically chiral and may be synthesized diastereoselectively through the use of an enantiopure diamine building block.
Keywords
Materials Chemistry, Biochemistry, General Chemistry, General Chemical Engineering, Biochemistry, medical, Environmental Chemistry, LANTHANIDE TEMPLATE SYNTHESIS, TREFOIL KNOT, SOLOMON LINK, RING, CATALYSIS, BINDING

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Citation

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MLA
Carpenter, John P., et al. “Controlling the Shape and Chirality of an Eight-Crossing Molecular Knot.” CHEM, vol. 7, no. 6, 2021, pp. 1534–43, doi:10.1016/j.chempr.2021.03.005.
APA
Carpenter, J. P., McTernan, C. T., Greenfield, J. L., Lavendomme, R., Ronson, T. K., & Nitschke, J. R. (2021). Controlling the shape and chirality of an eight-crossing molecular knot. CHEM, 7(6), 1534–1543. https://doi.org/10.1016/j.chempr.2021.03.005
Chicago author-date
Carpenter, John P., Charlie T. McTernan, Jake L. Greenfield, Roy Lavendomme, Tanya K. Ronson, and Jonathan R. Nitschke. 2021. “Controlling the Shape and Chirality of an Eight-Crossing Molecular Knot.” CHEM 7 (6): 1534–43. https://doi.org/10.1016/j.chempr.2021.03.005.
Chicago author-date (all authors)
Carpenter, John P., Charlie T. McTernan, Jake L. Greenfield, Roy Lavendomme, Tanya K. Ronson, and Jonathan R. Nitschke. 2021. “Controlling the Shape and Chirality of an Eight-Crossing Molecular Knot.” CHEM 7 (6): 1534–1543. doi:10.1016/j.chempr.2021.03.005.
Vancouver
1.
Carpenter JP, McTernan CT, Greenfield JL, Lavendomme R, Ronson TK, Nitschke JR. Controlling the shape and chirality of an eight-crossing molecular knot. CHEM. 2021;7(6):1534–43.
IEEE
[1]
J. P. Carpenter, C. T. McTernan, J. L. Greenfield, R. Lavendomme, T. K. Ronson, and J. R. Nitschke, “Controlling the shape and chirality of an eight-crossing molecular knot,” CHEM, vol. 7, no. 6, pp. 1534–1543, 2021.
@article{8714812,
  abstract     = {{The knotting of biomolecules impacts their function and enables them to carry out new tasks. Likewise, complex topologies underpin the operation of many synthetic molecular machines. The ability to generate and control more complex architectures is essential to endow these machines with more advanced functions. Here, we report the synthesis of a molecular knot with eight crossing points, consisting of a single organic loop woven about six templating metal centers, via one-pot self-assembly from a pair of simple dialdehyde and diamine subcomponents and a single metal salt. The structure and topology of the knot were established by NMR spectroscopy, mass spectrometry, and X-ray crystallography. Upon demetallation, the purely organic strand relaxes into a symmetric conformation, while retaining the topology of the original knot. This knot is topologically chiral and may be synthesized diastereoselectively through the use of an enantiopure diamine building block.}},
  author       = {{Carpenter, John P. and McTernan, Charlie T. and Greenfield, Jake L. and Lavendomme, Roy and Ronson, Tanya K. and Nitschke, Jonathan R.}},
  issn         = {{2451-9294}},
  journal      = {{CHEM}},
  keywords     = {{Materials Chemistry,Biochemistry,General Chemistry,General Chemical Engineering,Biochemistry,medical,Environmental Chemistry,LANTHANIDE TEMPLATE SYNTHESIS,TREFOIL KNOT,SOLOMON LINK,RING,CATALYSIS,BINDING}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1534--1543}},
  title        = {{Controlling the shape and chirality of an eight-crossing molecular knot}},
  url          = {{http://dx.doi.org/10.1016/j.chempr.2021.03.005}},
  volume       = {{7}},
  year         = {{2021}},
}

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