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Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study

(2010) DIABETES CARE. 33(1). p.190-196
Author
Organization
Abstract
OBJECTIVE - The peroxisome proliferator-activated receptor-gamma 2 (PPARG2) Pro12Ala polymorphism has been associated with a higher BMI and a lower risk of type 2 diabetes in adulthood. The association between adiposity and PPARG variants can be influenced by environmental factors such as early growth, dietary fat, and (as recently shown) breast-feeding. The objectives of this study were to assess 1) the influence of the PPARG2 Pro12Ala polymorphism on adiposity markers in adolescents and 2) a possible modulating effect of breast-feeding on these associations. RESEARCH DESIGN AND METHODS - Data on breast-feeding duration, BMI, and genotypes for the Pro12Ala polymorphism were available for 945 adolescents (mean age 14.7 years). The breast-feeding duration was obtained from parental records. We measured weight, height, waist circumference, and six skinfold thicknesses. RESULTS - No significant associations between the Pro12Ala polymorphism and any of the above-mentioned anthropometric parameters were found. There were significant interactions between the PPARG2 Pro12Ala polymorphism and breast-feeding with regard to adiposity measurements (all adjusted P < 0.05). Indeed, in children who had not been breast-fed, Ala12 allele carriers had higher adiposity parameters (e.g., Delta BMI + 1.88 kg/m(2), adjusted for age, sex, and center, P = 0.007) than Pro12Pro adolescents. In contrast, in breast-fed subjects, there was no significant difference between Ala12 allele carriers and Pro12Pro children in terms of adiposity measurements, whatever the duration of breast-feeding. CONCLUSIONS - Breast-feeding appears to counter the deleterious effect of the PPARG2 Pro12Ala polymorphism on anthropometric parameters in adolescents.
Keywords
IMPACT, WEIGHT, VARIANT, BODY-MASS, PPAR-GAMMA-2 GENE, ASSOCIATION, METAANALYSIS, GROWTH, OBESITY, BIRTH

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MLA
Verier, C et al. “Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Cross-sectional Study.” DIABETES CARE 33.1 (2010): 190–196. Print.
APA
Verier, C., Meirhaeghe, A., Bokor, S., Breidenassel, C., Manios, Y., Molnar, D., Artero, E., et al. (2010). Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. DIABETES CARE, 33(1), 190–196.
Chicago author-date
Verier, C, A Meirhaeghe, S Bokor, C Breidenassel, Y Manios, D Molnar, EG Artero, et al. 2010. “Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Cross-sectional Study.” Diabetes Care 33 (1): 190–196.
Chicago author-date (all authors)
Verier, C, A Meirhaeghe, S Bokor, C Breidenassel, Y Manios, D Molnar, EG Artero, E Nova, Stefaan De Henauw, LA Moreno, P Amouyel, I Labayen, N Bevilacqua, D Turck, L Beghin, J Dallongeville, and F Gottrand. 2010. “Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Cross-sectional Study.” Diabetes Care 33 (1): 190–196.
Vancouver
1.
Verier C, Meirhaeghe A, Bokor S, Breidenassel C, Manios Y, Molnar D, et al. Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. DIABETES CARE. ALEXANDRIA: AMER DIABETES ASSOC; 2010;33(1):190–6.
IEEE
[1]
C. Verier et al., “Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study,” DIABETES CARE, vol. 33, no. 1, pp. 190–196, 2010.
@article{871397,
  abstract     = {OBJECTIVE - The peroxisome proliferator-activated receptor-gamma 2 (PPARG2) Pro12Ala polymorphism has been associated with a higher BMI and a lower risk of type 2 diabetes in adulthood. The association between adiposity and PPARG variants can be influenced by environmental factors such as early growth, dietary fat, and (as recently shown) breast-feeding. The objectives of this study were to assess 1) the influence of the PPARG2 Pro12Ala polymorphism on adiposity markers in adolescents and 2) a possible modulating effect of breast-feeding on these associations.

RESEARCH DESIGN AND METHODS - Data on breast-feeding duration, BMI, and genotypes for the Pro12Ala polymorphism were available for 945 adolescents (mean age 14.7 years). The breast-feeding duration was obtained from parental records. We measured weight, height, waist circumference, and six skinfold thicknesses.

RESULTS - No significant associations between the Pro12Ala polymorphism and any of the above-mentioned anthropometric parameters were found. There were significant interactions between the PPARG2 Pro12Ala polymorphism and breast-feeding with regard to adiposity measurements (all adjusted P < 0.05). Indeed, in children who had not been breast-fed, Ala12 allele carriers had higher adiposity parameters (e.g., Delta BMI + 1.88 kg/m(2), adjusted for age, sex, and center, P = 0.007) than Pro12Pro adolescents. In contrast, in breast-fed subjects, there was no significant difference between Ala12 allele carriers and Pro12Pro children in terms of adiposity measurements, whatever the duration of breast-feeding.

CONCLUSIONS - Breast-feeding appears to counter the deleterious effect of the PPARG2 Pro12Ala polymorphism on anthropometric parameters in adolescents.},
  author       = {Verier, C and Meirhaeghe, A and Bokor, S and Breidenassel, C and Manios, Y and Molnar, D and Artero, EG and Nova, E and De Henauw, Stefaan and Moreno, LA and Amouyel, P and Labayen, I and Bevilacqua, N and Turck, D and Beghin, L and Dallongeville, J and Gottrand, F},
  issn         = {0149-5992},
  journal      = {DIABETES CARE},
  keywords     = {IMPACT,WEIGHT,VARIANT,BODY-MASS,PPAR-GAMMA-2 GENE,ASSOCIATION,METAANALYSIS,GROWTH,OBESITY,BIRTH},
  language     = {eng},
  number       = {1},
  pages        = {190--196},
  publisher    = {AMER DIABETES ASSOC},
  title        = {Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-gamma (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study},
  url          = {http://dx.doi.org/10.2337/dc09-1459},
  volume       = {33},
  year         = {2010},
}

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