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Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal-amygdala 5-HT2A receptor density

Chris Baeken (UGent) , Yanfeng Xu, Guo-Rong Wu, Robrecht Dockx, Kathelijne Peremans (UGent) and Rudi De Raedt (UGent)
(2021) EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 271(7). p.1369-1378
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Abstract
Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are severe and difficult-to-treat psychiatric illnesses with high rates of comorbidity. Although both disorders are treated with serotonergic based psychotropic agents, little is known on the influence of the serotonergic neurotransmitter system on the occurrence of comorbid GAD when clinically depressed. To investigate this poorly understood clinical question, we examined the involvement of frontolimbic post-synaptic 5-HT2A receptors in 20 medication-resistant depressed (MRD) patients with half of them diagnosed with comorbid GAD with I-123-5-I-R91150 SPECT. To explore whether 5-HT2A receptor-binding indices (BI) associated with comorbid GAD could be related to distinct psychopathological symptoms, all were assessed with the symptom Checklist-90-Revised (SCL-90-R). MRD patients with comorbid GAD displayed significantly higher 5-HT2A receptor BI in the hippocampal-amygdala complex, compared to MRD patients without GAD. Correlation analyses revealed that the 5-HT2A receptor BI in these areas were significantly related to the SCL-90-R subscale hostility (HOS), especially for those MRD patients with comorbid GAD. Comorbid MRD-GAD may be characterized with increased hippocampal-amygdala 5-HT2A receptor BI which could represent enhanced levels in hostility in such kinds of patients. Adapted psychotherapeutic interventions may be warranted.
Keywords
Pharmacology (medical), Biological Psychiatry, Psychiatry and Mental health, General Medicine, PITUITARY-ADRENAL AXIS, BINDING INDEX, UNCERTAINTY, INTOLERANCE, ANGER, I-123-5-I-R91150, RESPONSES, SYMPTOMS, DRUGS, DOGS, Major depressive disorder, Generalized anxiety disorder, Comorbidity, R91150 SPECT, serotonin 5-HT2A receptor

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MLA
Baeken, Chris, et al. “Hostility in Medication-Resistant Major Depression and Comorbid Generalized Anxiety Disorder Is Related to Increased Hippocampal-Amygdala 5-HT2A Receptor Density.” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, vol. 271, no. 7, 2021, pp. 1369–78, doi:10.1007/s00406-021-01243-1.
APA
Baeken, C., Xu, Y., Wu, G.-R., Dockx, R., Peremans, K., & De Raedt, R. (2021). Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal-amygdala 5-HT2A receptor density. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 271(7), 1369–1378. https://doi.org/10.1007/s00406-021-01243-1
Chicago author-date
Baeken, Chris, Yanfeng Xu, Guo-Rong Wu, Robrecht Dockx, Kathelijne Peremans, and Rudi De Raedt. 2021. “Hostility in Medication-Resistant Major Depression and Comorbid Generalized Anxiety Disorder Is Related to Increased Hippocampal-Amygdala 5-HT2A Receptor Density.” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 271 (7): 1369–78. https://doi.org/10.1007/s00406-021-01243-1.
Chicago author-date (all authors)
Baeken, Chris, Yanfeng Xu, Guo-Rong Wu, Robrecht Dockx, Kathelijne Peremans, and Rudi De Raedt. 2021. “Hostility in Medication-Resistant Major Depression and Comorbid Generalized Anxiety Disorder Is Related to Increased Hippocampal-Amygdala 5-HT2A Receptor Density.” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 271 (7): 1369–1378. doi:10.1007/s00406-021-01243-1.
Vancouver
1.
Baeken C, Xu Y, Wu G-R, Dockx R, Peremans K, De Raedt R. Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal-amygdala 5-HT2A receptor density. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2021;271(7):1369–78.
IEEE
[1]
C. Baeken, Y. Xu, G.-R. Wu, R. Dockx, K. Peremans, and R. De Raedt, “Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal-amygdala 5-HT2A receptor density,” EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, vol. 271, no. 7, pp. 1369–1378, 2021.
@article{8713008,
  abstract     = {{Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are severe and difficult-to-treat psychiatric illnesses with high rates of comorbidity. Although both disorders are treated with serotonergic based psychotropic agents, little is known on the influence of the serotonergic neurotransmitter system on the occurrence of comorbid GAD when clinically depressed. To investigate this poorly understood clinical question, we examined the involvement of frontolimbic post-synaptic 5-HT2A receptors in 20 medication-resistant depressed (MRD) patients with half of them diagnosed with comorbid GAD with I-123-5-I-R91150 SPECT. To explore whether 5-HT2A receptor-binding indices (BI) associated with comorbid GAD could be related to distinct psychopathological symptoms, all were assessed with the symptom Checklist-90-Revised (SCL-90-R). MRD patients with comorbid GAD displayed significantly higher 5-HT2A receptor BI in the hippocampal-amygdala complex, compared to MRD patients without GAD. Correlation analyses revealed that the 5-HT2A receptor BI in these areas were significantly related to the SCL-90-R subscale hostility (HOS), especially for those MRD patients with comorbid GAD. Comorbid MRD-GAD may be characterized with increased hippocampal-amygdala 5-HT2A receptor BI which could represent enhanced levels in hostility in such kinds of patients. Adapted psychotherapeutic interventions may be warranted.}},
  author       = {{Baeken, Chris and Xu, Yanfeng and Wu, Guo-Rong and Dockx, Robrecht and Peremans, Kathelijne and De Raedt, Rudi}},
  issn         = {{0940-1334}},
  journal      = {{EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE}},
  keywords     = {{Pharmacology (medical),Biological Psychiatry,Psychiatry and Mental health,General Medicine,PITUITARY-ADRENAL AXIS,BINDING INDEX,UNCERTAINTY,INTOLERANCE,ANGER,I-123-5-I-R91150,RESPONSES,SYMPTOMS,DRUGS,DOGS,Major depressive disorder,Generalized anxiety disorder,Comorbidity,R91150 SPECT,serotonin 5-HT2A receptor}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1369--1378}},
  title        = {{Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal-amygdala 5-HT2A receptor density}},
  url          = {{http://dx.doi.org/10.1007/s00406-021-01243-1}},
  volume       = {{271}},
  year         = {{2021}},
}
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