Evolution and function of the epithelial cell-specific ER stress sensor IRE1β
- Author
- Eva Cloots (UGent) , Mariska S. Simpson, Clint De Nolf (UGent) , Wayne I. Lencer, Sophie Janssens (UGent) and Michael J. Grey
- Organization
- Project
- Abstract
- Barrier epithelial cells lining the mucosal surfaces of the gastrointestinal and respiratory tracts interface directly with the environment. As such, these tissues are continuously challenged to maintain a healthy equilibrium between immunity and tolerance against environmental toxins, food components, and microbes. An extracellular mucus barrier, produced and secreted by the underlying epithelium plays a central role in this host defense response. Several dedicated molecules with a unique tissue-specific expression in mucosal epithelia govern mucosal homeostasis. Here, we review the biology of Inositol-requiring enzyme 1β (IRE1β), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1α. IRE1β arose through gene duplication in early vertebrates and adopted functions unique from IRE1α which appear to underlie the basic development and physiology of mucosal tissues.
- Keywords
- Immunology, Immunology and Allergy, UNFOLDED-PROTEIN-RESPONSE, ENDOPLASMIC-RETICULUM STRESS, TRANSFER-RNA LIGASE, XBP1 MESSENGER-RNA, TRANSCRIPTION FACTOR, GOBLET CELLS, IRE1 REVEALS, IRE1-ALPHA, ACTIVATION, DECAY
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8712815
- MLA
- Cloots, Eva, et al. “Evolution and Function of the Epithelial Cell-Specific ER Stress Sensor IRE1β.” MUCOSAL IMMUNOLOGY, vol. 14, no. 6, 2021, pp. 1235–46, doi:10.1038/s41385-021-00412-8.
- APA
- Cloots, E., Simpson, M. S., De Nolf, C., Lencer, W. I., Janssens, S., & Grey, M. J. (2021). Evolution and function of the epithelial cell-specific ER stress sensor IRE1β. MUCOSAL IMMUNOLOGY, 14(6), 1235–1246. https://doi.org/10.1038/s41385-021-00412-8
- Chicago author-date
- Cloots, Eva, Mariska S. Simpson, Clint De Nolf, Wayne I. Lencer, Sophie Janssens, and Michael J. Grey. 2021. “Evolution and Function of the Epithelial Cell-Specific ER Stress Sensor IRE1β.” MUCOSAL IMMUNOLOGY 14 (6): 1235–46. https://doi.org/10.1038/s41385-021-00412-8.
- Chicago author-date (all authors)
- Cloots, Eva, Mariska S. Simpson, Clint De Nolf, Wayne I. Lencer, Sophie Janssens, and Michael J. Grey. 2021. “Evolution and Function of the Epithelial Cell-Specific ER Stress Sensor IRE1β.” MUCOSAL IMMUNOLOGY 14 (6): 1235–1246. doi:10.1038/s41385-021-00412-8.
- Vancouver
- 1.Cloots E, Simpson MS, De Nolf C, Lencer WI, Janssens S, Grey MJ. Evolution and function of the epithelial cell-specific ER stress sensor IRE1β. MUCOSAL IMMUNOLOGY. 2021;14(6):1235–46.
- IEEE
- [1]E. Cloots, M. S. Simpson, C. De Nolf, W. I. Lencer, S. Janssens, and M. J. Grey, “Evolution and function of the epithelial cell-specific ER stress sensor IRE1β,” MUCOSAL IMMUNOLOGY, vol. 14, no. 6, pp. 1235–1246, 2021.
@article{8712815,
abstract = {{Barrier epithelial cells lining the mucosal surfaces of the gastrointestinal and respiratory tracts interface directly with the environment. As such, these tissues are continuously challenged to maintain a healthy equilibrium between immunity and tolerance against environmental toxins, food components, and microbes. An extracellular mucus barrier, produced and secreted by the underlying epithelium plays a central role in this host defense response. Several dedicated molecules with a unique tissue-specific expression in mucosal epithelia govern mucosal homeostasis. Here, we review the biology of Inositol-requiring enzyme 1β (IRE1β), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1α. IRE1β arose through gene duplication in early vertebrates and adopted functions unique from IRE1α which appear to underlie the basic development and physiology of mucosal tissues.}},
author = {{Cloots, Eva and Simpson, Mariska S. and De Nolf, Clint and Lencer, Wayne I. and Janssens, Sophie and Grey, Michael J.}},
issn = {{1933-0219}},
journal = {{MUCOSAL IMMUNOLOGY}},
keywords = {{Immunology,Immunology and Allergy,UNFOLDED-PROTEIN-RESPONSE,ENDOPLASMIC-RETICULUM STRESS,TRANSFER-RNA LIGASE,XBP1 MESSENGER-RNA,TRANSCRIPTION FACTOR,GOBLET CELLS,IRE1 REVEALS,IRE1-ALPHA,ACTIVATION,DECAY}},
language = {{eng}},
number = {{6}},
pages = {{1235--1246}},
title = {{Evolution and function of the epithelial cell-specific ER stress sensor IRE1β}},
url = {{http://doi.org/10.1038/s41385-021-00412-8}},
volume = {{14}},
year = {{2021}},
}
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