@article{8710915,
  abstract     = {{OBJECTIVES Directed graph-mapping (DGM) is a novel operator-independent automatic tool that can be applied to the identification of the atrial tachycardia (AT) mechanism. In the present study, for the first time, DGM was applied in complex AT cases, and diagnostic accuracy was evaluated. BACKGROUND Catheter ablation of ATs still represents a challenge, as the identification of the correct mechanism can be difficult. New algorithms for high-density activation mapping (HDAM) render an easier acquisition of more detailed maps; however, understanding of the mechanism and, thus, identification of the ablation targets, especially in complex cases, remains strongly operator-dependent. METHODS HDAMs acquired with the latest algorithm (COHERENT version 7, Biosense Webster, Irvine, California) were interpreted offline by 4 expert electrophysiologists, and the acquired electrode recordings with corresponding local activation times (LATs) were analyzed by DGM (also offline). Entrainment maneuvers (EM) were performed to understand the correct mechanism, which was then confirmed by successful ablation (13 cases were centrifugal, 10 cases were localized re-entry, 22 cases were macro-re-entry, and 6 were double-loops). In total, 51 ATs were retrospectively analyzed. We compared the diagnoses made by DGM were compared with those of the experts and with additional EM results. RESULTS In total, 51 ATs were retrospectively analyzed. Experts diagnosed the correct AT mechanism and location in 33 cases versus DGM in 38 cases. Diagnostic accuracy varied according to different AT mechanisms. The 13 centrifugal activation patterns were always correctly identified by both methods; 2 of 10 localized reentries were identified by the experts, whereas DGM diagnosed 7 of 10. For the macro-re-entries, 12 of 22 were correctly identified using HDAM versus 13 of 22 for DGM. Finally, 6 of 6 double-loops were correctly identified by the experts, versus 5 of 6 for DGM. CONCLUSIONS Even in complex cases, DGM provides an automatic, fast, and operator-independent tool to identify the AT mechanism and location and could be a valuable addition to current mapping technologies. (J Am Coll Cardiol EP 2021;7:936-49) (c) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).}},
  author       = {{Van Nieuwenhuyse, Enid and Strisciuglio, Teresa and Lorenzo, Giuseppe and El Haddad, Milad and Goedgebeur, Jan and Van Cleemput, Nicolas and Ley, Christophe and Panfilov, Alexander and De Pooter, Jan and Vandekerckhove, Yves and Tavernier, Rene and Duytschaever, Mattias and Knecht, Sebastien and Vandersickel, Nele}},
  issn         = {{2405-500X}},
  journal      = {{JACC-CLINICAL ELECTROPHYSIOLOGY}},
  keywords     = {{Physiology (medical),Cardiology and Cardiovascular Medicine,catheter ablation,DGM,directed graph-mapping,network theory,atrial tachycardia,CATHETER ABLATION,FIBRILLATION}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{936--949}},
  title        = {{Evaluation of directed graph-mapping in complex atrial tachycardias}},
  url          = {{http://doi.org/10.1016/j.jacep.2020.12.013}},
  volume       = {{7}},
  year         = {{2021}},
}

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