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Immunopeptidomics for next-generation bacterial vaccine development

Rupert Mayer (UGent) and Francis Impens (UGent)
(2021) TRENDS IN MICROBIOLOGY. 29(11). p.1034-1045
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Abstract
Antimicrobial resistance is an increasing global threat and alternative treatments substituting failing antibiotics are urgently needed. Vaccines are recognized as highly effective tools to mitigate antimicrobial resistance; however, the selection of bacterial antigens as vaccine candidates remains challenging. In recent years, advances in mass spectrometry-based proteomics have led to the development of so-called immunopeptidomics approaches that allow the untargeted discovery of bacterial epitopes that are presented on the surface of infected cells. Especially for intracellular bacterial pathogens, immunopeptidomics holds great promise to uncover antigens that can be encoded in viral vector- or nucleic acid-based vaccines. This review provides an overview of immunopeptidomics studies on intracellular bacterial pathogens and considers future directions and challenges in advancing towards next-generation vaccines.
Keywords
MESSENGER-RNA VACCINES, T-CELL ANTIGENS, HLA-E BINDS, MYCOBACTERIUM-TUBERCULOSIS, LISTERIA-MONOCYTOGENES, MASS-SPECTROMETRY, IMMUNE-RESPONSES, PHOSPHORYLATED PEPTIDES, GAMMA, INTERFERON

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MLA
Mayer, Rupert, and Francis Impens. “Immunopeptidomics for Next-Generation Bacterial Vaccine Development.” TRENDS IN MICROBIOLOGY, vol. 29, no. 11, 2021, pp. 1034–45, doi:10.1016/j.tim.2021.04.010.
APA
Mayer, R., & Impens, F. (2021). Immunopeptidomics for next-generation bacterial vaccine development. TRENDS IN MICROBIOLOGY, 29(11), 1034–1045. https://doi.org/10.1016/j.tim.2021.04.010
Chicago author-date
Mayer, Rupert, and Francis Impens. 2021. “Immunopeptidomics for Next-Generation Bacterial Vaccine Development.” TRENDS IN MICROBIOLOGY 29 (11): 1034–45. https://doi.org/10.1016/j.tim.2021.04.010.
Chicago author-date (all authors)
Mayer, Rupert, and Francis Impens. 2021. “Immunopeptidomics for Next-Generation Bacterial Vaccine Development.” TRENDS IN MICROBIOLOGY 29 (11): 1034–1045. doi:10.1016/j.tim.2021.04.010.
Vancouver
1.
Mayer R, Impens F. Immunopeptidomics for next-generation bacterial vaccine development. TRENDS IN MICROBIOLOGY. 2021;29(11):1034–45.
IEEE
[1]
R. Mayer and F. Impens, “Immunopeptidomics for next-generation bacterial vaccine development,” TRENDS IN MICROBIOLOGY, vol. 29, no. 11, pp. 1034–1045, 2021.
@article{8710139,
  abstract     = {{Antimicrobial resistance is an increasing global threat and alternative treatments substituting failing antibiotics are urgently needed. Vaccines are recognized as highly effective tools to mitigate antimicrobial resistance; however, the selection of bacterial antigens as vaccine candidates remains challenging. In recent years, advances in mass spectrometry-based proteomics have led to the development of so-called immunopeptidomics approaches that allow the untargeted discovery of bacterial epitopes that are presented on the surface of infected cells. Especially for intracellular bacterial pathogens, immunopeptidomics holds great promise to uncover antigens that can be encoded in viral vector- or nucleic acid-based vaccines. This review provides an overview of immunopeptidomics studies on intracellular bacterial pathogens and considers future directions and challenges in advancing towards next-generation vaccines.}},
  author       = {{Mayer, Rupert and Impens, Francis}},
  issn         = {{0966-842X}},
  journal      = {{TRENDS IN MICROBIOLOGY}},
  keywords     = {{MESSENGER-RNA VACCINES,T-CELL ANTIGENS,HLA-E BINDS,MYCOBACTERIUM-TUBERCULOSIS,LISTERIA-MONOCYTOGENES,MASS-SPECTROMETRY,IMMUNE-RESPONSES,PHOSPHORYLATED PEPTIDES,GAMMA,INTERFERON}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1034--1045}},
  title        = {{Immunopeptidomics for next-generation bacterial vaccine development}},
  url          = {{http://doi.org/10.1016/j.tim.2021.04.010}},
  volume       = {{29}},
  year         = {{2021}},
}

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