@article{8708950,
  abstract     = {{Transcranial Direct Current Stimulation (tDCS) is an effective treatment during the acute phase of a major depressive episode (MDE), although the evidence for its follow-up efficacy is mixed. A systematic review and meta-analysis were performed. MEDLINE/PubMed, Scopus (EMBASE), Web of Science, Cochrane Library and additional sources were searched from inception to April 29, 2021. Studies that followed up adults treated with tDCS during an MDE - using (interventional) and/or not using (observational) tDCS in the follow-up period were included. The primary outcome was the Hedges' g for the follow-up depression scores. Small study effects and sources of heterogeneity were explored. 427 studies were retrieved and 11 trials (13 datasets, n = 311) were included, most presenting moderate bias. Results showed a follow-up depression improvement (k = 13, g = -0.81, 95% confidence interval [CI]: -1.28; -0.34, I-2 = 84.0%), which was probably driven by the interventional studies (k = 7, g = -1.12, 95% CI: -1.84; -0.40, I-2 = 87.1%). No predictor of response was associated with the outcome. No risk of publication bias was found. Significant between-study heterogeneity may have influenced the overall results. Our findings suggest that tDCS produces effects beyond the intervention period during MDEs. Maintenance sessions are advised in future research.}},
  articleno    = {{114024}},
  author       = {{Razza, Laís and De Smet, Stefanie and Moffa, Adriano and Sudbrack-Oliveira, Pedro and Vanderhasselt, Marie-Anne and Brunoni, André}},
  issn         = {{0165-1781}},
  journal      = {{PSYCHIATRY RESEARCH}},
  keywords     = {{Biological Psychiatry,Psychiatry and Mental health,Depression,Transcranial direct current stimulation,Meta-analysis,Follow-up,Long-term effects,DOUBLE-BLIND,CONTROLLED TRIAL,THERAPY,DISORDER}},
  language     = {{eng}},
  pages        = {{7}},
  title        = {{Follow-up effects of transcranial direct current stimulation (tDCS) for the major depressive episode : a systematic review and meta-analysis}},
  url          = {{http://dx.doi.org/10.1016/j.psychres.2021.114024}},
  volume       = {{302}},
  year         = {{2021}},
}

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