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Sequence-encoded macromolecules with increased data storage capacity through a thiol-epoxy reaction

Matthieu Soete (UGent) , Chiel Mertens (UGent) , Resat Aksakal (UGent) , Nezha Badi (UGent) and Filip Du Prez (UGent)
(2021) ACS MACRO LETTERS. 10(5). p.616-622
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Abstract
Sequence-encoded oligo(thioether urethane)s with two different coding monomers per backbone unit were prepared via a solid phase, two-step iterative protocol based on thiolactone chemistry. The first step of the synthetic cycle consists of the thiolactone ring opening with a primary amine, whereby the in situ released thiol is immediately reacted with an epoxide. In the second step, the thiolactone group is reinstalled to initiate the next cycle. This strategy allows to introduce two different coding monomers per synthetic cycle, rendering the resulting macromolecules especially attractive in the area of (macro)molecular data storage because of their increased data storage capacity. Subsequently, the efficiency of the herein reported synthesis route and the applicability of the dual-encoded sequence-defined macromolecules as a potential data storage platform have been demonstrated by unraveling the exact monomer order using tandem mass spectrometry techniques.
Keywords
DEFINED OLIGOMERS, POLYMERS

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MLA
Soete, Matthieu, et al. “Sequence-Encoded Macromolecules with Increased Data Storage Capacity through a Thiol-Epoxy Reaction.” ACS MACRO LETTERS, vol. 10, no. 5, 2021, pp. 616–22, doi:10.1021/acsmacrolett.1c00275.
APA
Soete, M., Mertens, C., Aksakal, R., Badi, N., & Du Prez, F. (2021). Sequence-encoded macromolecules with increased data storage capacity through a thiol-epoxy reaction. ACS MACRO LETTERS, 10(5), 616–622. https://doi.org/10.1021/acsmacrolett.1c00275
Chicago author-date
Soete, Matthieu, Chiel Mertens, Resat Aksakal, Nezha Badi, and Filip Du Prez. 2021. “Sequence-Encoded Macromolecules with Increased Data Storage Capacity through a Thiol-Epoxy Reaction.” ACS MACRO LETTERS 10 (5): 616–22. https://doi.org/10.1021/acsmacrolett.1c00275.
Chicago author-date (all authors)
Soete, Matthieu, Chiel Mertens, Resat Aksakal, Nezha Badi, and Filip Du Prez. 2021. “Sequence-Encoded Macromolecules with Increased Data Storage Capacity through a Thiol-Epoxy Reaction.” ACS MACRO LETTERS 10 (5): 616–622. doi:10.1021/acsmacrolett.1c00275.
Vancouver
1.
Soete M, Mertens C, Aksakal R, Badi N, Du Prez F. Sequence-encoded macromolecules with increased data storage capacity through a thiol-epoxy reaction. ACS MACRO LETTERS. 2021;10(5):616–22.
IEEE
[1]
M. Soete, C. Mertens, R. Aksakal, N. Badi, and F. Du Prez, “Sequence-encoded macromolecules with increased data storage capacity through a thiol-epoxy reaction,” ACS MACRO LETTERS, vol. 10, no. 5, pp. 616–622, 2021.
@article{8707564,
  abstract     = {{Sequence-encoded oligo(thioether urethane)s with two different coding monomers per backbone unit were prepared via a solid phase, two-step iterative protocol based on thiolactone chemistry. The first step of the synthetic cycle consists of the thiolactone ring opening with a primary amine, whereby the in situ released thiol is immediately reacted with an epoxide. In the second step, the thiolactone group is reinstalled to initiate the next cycle. This strategy allows to introduce two different coding monomers per synthetic cycle, rendering the resulting macromolecules especially attractive in the area of (macro)molecular data storage because of their increased data storage capacity. Subsequently, the efficiency of the herein reported synthesis route and the applicability of the dual-encoded sequence-defined macromolecules as a potential data storage platform have been demonstrated by unraveling the exact monomer order using tandem mass spectrometry techniques.}},
  author       = {{Soete, Matthieu and Mertens, Chiel and Aksakal, Resat and Badi, Nezha and Du Prez, Filip}},
  issn         = {{2161-1653}},
  journal      = {{ACS MACRO LETTERS}},
  keywords     = {{DEFINED OLIGOMERS,POLYMERS}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{616--622}},
  title        = {{Sequence-encoded macromolecules with increased data storage capacity through a thiol-epoxy reaction}},
  url          = {{http://dx.doi.org/10.1021/acsmacrolett.1c00275}},
  volume       = {{10}},
  year         = {{2021}},
}

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