@article{8707466,
  abstract     = {{The human gut is inhabited by a large variety of microorganims involved in many physiological processes and collectively referred as to gut microbiota. Disrupted microbiome has been associated with negative health outcomes and especially could promote the onset of enteric infections. To sustain their growth and persistence within the human digestive tract, gut microbes and enteric pathogens rely on two main polysaccharide compartments, namely dietary fibers and mucus carbohydrates. Several evidences suggest that the three-way relationship between gut microbiota, dietary fibers and mucus layer could unravel the capacity of enteric pathogens to colonise the human digestive tract and ultimately lead to infection. The review starts by shedding light on similarities and differences between dietary fibers and mucus carbohydrates structures and functions. Next, we provide an overview of the interactions of these two components with the third partner, namely, the gut microbiota, under health and disease situations. The review will then provide insights into the relevance of using dietary fibers interventions to prevent enteric infections with a focus on gut microbial imbalance and impaired-mucus integrity. Facing the numerous challenges in studying microbiota-pathogen-dietary fiber-mucus interactions, we lastly describe the characteristics and potentialities of currently available in vitro models of the human gut.}},
  articleno    = {{fuaa052}},
  author       = {{Sauvaitre, Thomas and Etienne-Mesmin, Lucie and Sivignon, Adeline and Mosoni, Pascale and Courtin, Christophe M. and Van de Wiele, Tom and Blanquet-Diot, Stephanie}},
  issn         = {{0168-6445}},
  journal      = {{FEMS MICROBIOLOGY REVIEWS}},
  keywords     = {{dietary fibers,mucus,gut microbiota,enteric pathogens,in vitro gut models}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{36}},
  title        = {{Tripartite relationship between gut microbiota, intestinal mucus and dietary fibers : towards preventive strategies against enteric infections}},
  url          = {{http://doi.org/10.1093/femsre/fuaa052}},
  volume       = {{45}},
  year         = {{2021}},
}

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