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Vitamine B12 deficiency in children : a diagnostic challenge

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Abstract
Cobalamin or vitamin B12 (vitB12) is involved in DNA synthesis, haematopoiesis and myelinisation. Consequently, vitB12 deficiency causes various symptoms, such as megaloblastic anaemia, neurologic signs or pancytopenia. Despite possible severe symptoms, vitB12 deficiency can present asymptomatically. We report six paediatric patients with different aetiologies of vitB12 deficiency ranging from a subtle to a more overt presentation. VitB12 deficiency is a diagnostic challenge due to the lack of consensus on normal values of vitB12 and its co-markers (folate, holotranscobalamin, methylmalonic acid, homocysteine) and the lack in specificity and sensitivity of the serum vitB12 analysis. All cases were treated with parenteral vitB12. Last decades, evidence supporting high dose oral treatment being as effective as the intramuscular (IM) therapy, also in children, is growing.
Keywords
vitB12 deficiency, cobalamin deficiency, children

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Citation

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MLA
Van Vlaenderen, Joke, et al. “Vitamine B12 Deficiency in Children : A Diagnostic Challenge.” ACTA GASTRO-ENTEROLOGICA BELGICA, vol. 84, no. 1, 2021, pp. 121–24.
APA
Van Vlaenderen, J., Christiaens, J., Van Winckel, M., De Bruyne, R., Vande Velde, S., & Van Biervliet, S. (2021). Vitamine B12 deficiency in children : a diagnostic challenge. ACTA GASTRO-ENTEROLOGICA BELGICA, 84(1), 121–124.
Chicago author-date
Van Vlaenderen, Joke, Jakob Christiaens, Myriam Van Winckel, Ruth De Bruyne, Saskia Vande Velde, and Stephanie Van Biervliet. 2021. “Vitamine B12 Deficiency in Children : A Diagnostic Challenge.” ACTA GASTRO-ENTEROLOGICA BELGICA 84 (1): 121–24.
Chicago author-date (all authors)
Van Vlaenderen, Joke, Jakob Christiaens, Myriam Van Winckel, Ruth De Bruyne, Saskia Vande Velde, and Stephanie Van Biervliet. 2021. “Vitamine B12 Deficiency in Children : A Diagnostic Challenge.” ACTA GASTRO-ENTEROLOGICA BELGICA 84 (1): 121–124.
Vancouver
1.
Van Vlaenderen J, Christiaens J, Van Winckel M, De Bruyne R, Vande Velde S, Van Biervliet S. Vitamine B12 deficiency in children : a diagnostic challenge. ACTA GASTRO-ENTEROLOGICA BELGICA. 2021;84(1):121–4.
IEEE
[1]
J. Van Vlaenderen, J. Christiaens, M. Van Winckel, R. De Bruyne, S. Vande Velde, and S. Van Biervliet, “Vitamine B12 deficiency in children : a diagnostic challenge,” ACTA GASTRO-ENTEROLOGICA BELGICA, vol. 84, no. 1, pp. 121–124, 2021.
@article{8706487,
  abstract     = {{Cobalamin or vitamin B12 (vitB12) is involved in DNA synthesis, haematopoiesis and myelinisation. Consequently, vitB12 deficiency causes various symptoms, such as megaloblastic anaemia, neurologic signs or pancytopenia. Despite possible severe symptoms, vitB12 deficiency can present asymptomatically. We report six paediatric patients with different aetiologies of vitB12 deficiency ranging from a subtle to a more overt presentation. VitB12 deficiency is a diagnostic challenge due to the lack of consensus on normal values of vitB12 and its co-markers (folate, holotranscobalamin, methylmalonic acid, homocysteine) and the lack in specificity and sensitivity of the serum vitB12 analysis. All cases were treated with parenteral vitB12. Last decades, evidence supporting high dose oral treatment being as effective as the intramuscular (IM) therapy, also in children, is growing.}},
  author       = {{Van Vlaenderen, Joke and Christiaens, Jakob and Van Winckel, Myriam and De Bruyne, Ruth and Vande Velde, Saskia and Van Biervliet, Stephanie}},
  issn         = {{1784-3227}},
  journal      = {{ACTA GASTRO-ENTEROLOGICA BELGICA}},
  keywords     = {{vitB12 deficiency,cobalamin deficiency,children}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{121--124}},
  title        = {{Vitamine B12 deficiency in children : a diagnostic challenge}},
  volume       = {{84}},
  year         = {{2021}},
}

Web of Science
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