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Fibrotic enzymes modulate wound-induced skin tumorigenesis

Lisette Van Hove (UGent) , Kim Lecomte (UGent) , Jana Roels (UGent) , Niels Vandamme (UGent) , Hanna-Kaisa Vikkula (UGent) , Isabelle Hoorens (UGent) , Katia Ongenae (UGent) , Tino Hochepied (UGent) , Giacomo Donati, Yvan Saeys (UGent) , et al.
(2021) EMBO REPORTS. 2021.
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Abstract
Fibroblasts are a major component of the microenvironment of most solid tumours. Recent research elucidated a large heterogeneity and plasticity of activated fibroblasts, indicating that their role in cancer initiation, growth and metastasis is complex and context-dependent. Here, we performed genome-wide expression analysis comparing fibroblasts in normal, inflammatory and tumour-associated skin. Cancer-associated fibroblasts (CAFs) exhibit a fibrotic gene signature in wound-induced tumours, demonstrating persistent extracellular matrix (ECM) remodelling within these tumours. A top upregulated gene in mouse CAFs encodes for PRSS35, a protease capable of collagen remodelling. In human skin, we observed PRSS35 expression uniquely in the stroma of high-grade squamous cell carcinomas. Ablation of PRSS35 in mouse models of wound- or chemically-induced tumorigenesis resulted in aberrant collagen composition in the ECM and increased tumour incidence. Our results indicate that fibrotic enzymes expressed by CAFs can regulate squamous tumour initiation by remodelling the ECM.
Keywords
cancer&#8208, associated fibroblasts, fibrosis, PRSS35, skin cancer, wound healing

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MLA
Van Hove, Lisette, et al. “Fibrotic Enzymes Modulate Wound-Induced Skin Tumorigenesis.” EMBO REPORTS, vol. 2021, 2021, doi:10.15252/embr.202051573.
APA
Van Hove, L., Lecomte, K., Roels, J., Vandamme, N., Vikkula, H.-K., Hoorens, I., … Hoste, E. (2021). Fibrotic enzymes modulate wound-induced skin tumorigenesis. EMBO REPORTS, 2021. https://doi.org/10.15252/embr.202051573
Chicago author-date
Van Hove, Lisette, Kim Lecomte, Jana Roels, Niels Vandamme, Hanna-Kaisa Vikkula, Isabelle Hoorens, Katia Ongenae, et al. 2021. “Fibrotic Enzymes Modulate Wound-Induced Skin Tumorigenesis.” EMBO REPORTS 2021. https://doi.org/10.15252/embr.202051573.
Chicago author-date (all authors)
Van Hove, Lisette, Kim Lecomte, Jana Roels, Niels Vandamme, Hanna-Kaisa Vikkula, Isabelle Hoorens, Katia Ongenae, Tino Hochepied, Giacomo Donati, Yvan Saeys, Sven R. Quist, Fiona M. Watt, Geert van Loo, and Esther Hoste. 2021. “Fibrotic Enzymes Modulate Wound-Induced Skin Tumorigenesis.” EMBO REPORTS 2021. doi:10.15252/embr.202051573.
Vancouver
1.
Van Hove L, Lecomte K, Roels J, Vandamme N, Vikkula H-K, Hoorens I, et al. Fibrotic enzymes modulate wound-induced skin tumorigenesis. EMBO REPORTS. 2021;2021.
IEEE
[1]
L. Van Hove et al., “Fibrotic enzymes modulate wound-induced skin tumorigenesis,” EMBO REPORTS, vol. 2021, 2021.
@article{8705702,
  abstract     = {{Fibroblasts are a major component of the microenvironment of most solid tumours. Recent research elucidated a large heterogeneity and plasticity of activated fibroblasts, indicating that their role in cancer initiation, growth and metastasis is complex and context-dependent. Here, we performed genome-wide expression analysis comparing fibroblasts in normal, inflammatory and tumour-associated skin. Cancer-associated fibroblasts (CAFs) exhibit a fibrotic gene signature in wound-induced tumours, demonstrating persistent extracellular matrix (ECM) remodelling within these tumours. A top upregulated gene in mouse CAFs encodes for PRSS35, a protease capable of collagen remodelling. In human skin, we observed PRSS35 expression uniquely in the stroma of high-grade squamous cell carcinomas. Ablation of PRSS35 in mouse models of wound- or chemically-induced tumorigenesis resulted in aberrant collagen composition in the ECM and increased tumour incidence. Our results indicate that fibrotic enzymes expressed by CAFs can regulate squamous tumour initiation by remodelling the ECM.}},
  articleno    = {{e51573}},
  author       = {{Van Hove, Lisette and Lecomte, Kim and Roels, Jana and Vandamme, Niels and Vikkula, Hanna-Kaisa and Hoorens, Isabelle and Ongenae, Katia and Hochepied, Tino and Donati, Giacomo and Saeys, Yvan and Quist, Sven R. and Watt, Fiona M. and van Loo, Geert and Hoste, Esther}},
  issn         = {{1469-221X}},
  journal      = {{EMBO REPORTS}},
  keywords     = {{cancer&#8208,associated fibroblasts,fibrosis,PRSS35,skin cancer,wound healing}},
  language     = {{eng}},
  pages        = {{15}},
  title        = {{Fibrotic enzymes modulate wound-induced skin tumorigenesis}},
  url          = {{http://dx.doi.org/10.15252/embr.202051573}},
  volume       = {{2021}},
  year         = {{2021}},
}

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