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Evaluation of multi‑feature auditory deviance detection in Parkinson’s disease : a mismatch negativity study

Evelien De Groote (UGent) , Annelies Bockstael (UGent) , Dick Botteldooren (UGent) , Patrick Santens (UGent) and Miet De Letter (UGent)
(2021) JOURNAL OF NEURAL TRANSMISSION. 128(5). p.645-657
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Abstract
Behavioral studies on auditory deviance detection in patients with Parkinson’s disease (PD) have reported contradictory results. The primary aim of this study was to investigate auditory deviance detection of multiple auditory features in patients with PD by means of objective and reliable electroencephalographic (EEG) measurements. Twelve patients with early-stage PD and twelve age- and gender-matched healthy controls (HCs) were included in this study. Patients with PD participated without their regular dopaminergic medication. All subjects underwent an audiometric screening and performed a passive multi-feature mismatch negativity (MMN) paradigm. Repeated-measures analysis of variance (ANOVA) demonstrated no significant differences between patients with PD and HCs regarding MMN mean amplitude and latency for frequency, duration and gap deviants. Nevertheless, a trend towards increased MMN mean amplitude and latency was found in response to intensity deviants in patients with PD compared to HCs. Increased intensity MMN amplitude may indicate that more neural resources are allocated to the processing of intensity deviances in patients with PD compared to HCs. The interpretation of this intensity-specific MMN alteration is further discussed in the context of a compensatory mechanism for auditory intensity processing and involuntary attention switching in PD.
Keywords
Parkinson’s disease (PD), Mismatch negativity (MMN), Auditory event-related potentials (ERPs), Auditory deviance detection, MONTREAL COGNITIVE ASSESSMENT, SELECTIVE-ATTENTION, INVOLUNTARY ATTENTION, TEMPORAL DISCRIMINATION, SUBTHALAMIC NUCLEUS, NONMOTOR SYMPTOMS, PERCEPTION, IMPAIRMENT, MMN, INTENSITY

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MLA
De Groote, Evelien, et al. “Evaluation of Multi‑feature Auditory Deviance Detection in Parkinson’s Disease : A Mismatch Negativity Study.” JOURNAL OF NEURAL TRANSMISSION, edited by Etienne Hirsch, vol. 128, no. 5, 2021, pp. 645–57, doi:10.1007/s00702-021-02341-z.
APA
De Groote, E., Bockstael, A., Botteldooren, D., Santens, P., & De Letter, M. (2021). Evaluation of multi‑feature auditory deviance detection in Parkinson’s disease : a mismatch negativity study. JOURNAL OF NEURAL TRANSMISSION, 128(5), 645–657. https://doi.org/10.1007/s00702-021-02341-z
Chicago author-date
De Groote, Evelien, Annelies Bockstael, Dick Botteldooren, Patrick Santens, and Miet De Letter. 2021. “Evaluation of Multi‑feature Auditory Deviance Detection in Parkinson’s Disease : A Mismatch Negativity Study.” Edited by Etienne Hirsch. JOURNAL OF NEURAL TRANSMISSION 128 (5): 645–57. https://doi.org/10.1007/s00702-021-02341-z.
Chicago author-date (all authors)
De Groote, Evelien, Annelies Bockstael, Dick Botteldooren, Patrick Santens, and Miet De Letter. 2021. “Evaluation of Multi‑feature Auditory Deviance Detection in Parkinson’s Disease : A Mismatch Negativity Study.” Ed by. Etienne Hirsch. JOURNAL OF NEURAL TRANSMISSION 128 (5): 645–657. doi:10.1007/s00702-021-02341-z.
Vancouver
1.
De Groote E, Bockstael A, Botteldooren D, Santens P, De Letter M. Evaluation of multi‑feature auditory deviance detection in Parkinson’s disease : a mismatch negativity study. Hirsch E, editor. JOURNAL OF NEURAL TRANSMISSION. 2021;128(5):645–57.
IEEE
[1]
E. De Groote, A. Bockstael, D. Botteldooren, P. Santens, and M. De Letter, “Evaluation of multi‑feature auditory deviance detection in Parkinson’s disease : a mismatch negativity study,” JOURNAL OF NEURAL TRANSMISSION, vol. 128, no. 5, pp. 645–657, 2021.
@article{8705370,
  abstract     = {{Behavioral studies on auditory deviance detection in patients with Parkinson’s disease (PD) have reported contradictory results. The primary aim of this study was to investigate auditory deviance detection of multiple auditory features in patients with PD by means of objective and reliable electroencephalographic (EEG) measurements. Twelve patients with early-stage PD and twelve age- and gender-matched healthy controls (HCs) were included in this study. Patients with PD participated without their regular dopaminergic medication. All subjects underwent an audiometric screening and performed a passive multi-feature mismatch negativity (MMN) paradigm. Repeated-measures analysis of variance (ANOVA) demonstrated no significant differences between patients with PD and HCs regarding MMN mean amplitude and latency for frequency, duration and gap deviants. Nevertheless, a trend towards increased MMN mean amplitude and latency was found in response to intensity deviants in patients with PD compared to HCs. Increased intensity MMN amplitude may indicate that more neural resources are allocated to the processing of intensity deviances in patients with PD compared to HCs. The interpretation of this intensity-specific MMN alteration is further discussed in the context of a compensatory mechanism for auditory intensity processing and involuntary attention switching in PD.}},
  author       = {{De Groote, Evelien and Bockstael, Annelies and Botteldooren, Dick and Santens, Patrick and De Letter, Miet}},
  editor       = {{Hirsch, Etienne}},
  issn         = {{0300-9564}},
  journal      = {{JOURNAL OF NEURAL TRANSMISSION}},
  keywords     = {{Parkinson’s disease (PD),Mismatch negativity (MMN),Auditory event-related potentials (ERPs),Auditory deviance detection,MONTREAL COGNITIVE ASSESSMENT,SELECTIVE-ATTENTION,INVOLUNTARY ATTENTION,TEMPORAL DISCRIMINATION,SUBTHALAMIC NUCLEUS,NONMOTOR SYMPTOMS,PERCEPTION,IMPAIRMENT,MMN,INTENSITY}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{645--657}},
  title        = {{Evaluation of multi‑feature auditory deviance detection in Parkinson’s disease : a mismatch negativity study}},
  url          = {{http://dx.doi.org/10.1007/s00702-021-02341-z}},
  volume       = {{128}},
  year         = {{2021}},
}

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