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Liver-type fatty acid-binding protein and neutrophil gelatinase-associated lipocalin in cats with chronic kidney disease and hyperthyroidism

Thirawut Kongtasai (UGent) , Evelyne Meyer (UGent) , Dominique Paepe (UGent) , Sofie Marynissen (UGent) , Pascale Smets (UGent) , Femke Mortier (UGent) , Kristel Demeyere (UGent) , Eva Vandermeulen (UGent) , Emmelie Stock (UGent) , Eva Buresova, et al.
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Abstract
Background Liver-type fatty acid-binding protein (L-FABP) and neutrophil gelatinase-associated lipocalin (NGAL) are candidate biomarkers for the detection of early chronic kidney disease (CKD) in cats. Objective To evaluate urinary and serum L-FABP and NGAL concentrations in CKD cats and in hyperthyroid cats before and after radioiodine (I-131) treatment. Animals Nine CKD cats, 45 healthy cats and hyperthyroid cats at 3 time points including before (T0, n = 49), 1 month (T1, n = 49), and 11 to 29 months after (T2, n = 26) I-131 treatment. Methods Cross-sectional and longitudinal study. Serum L-FABP (sL-FABP), serum NGAL (sNGAL), urinary L-FABP (uL-FABP), and urinary NGAL (uNGAL) were compared between the 3 groups and between hyperthyroid cats before and after treatment. Data are reported as median (min-max). Results CKD cats had significantly higher sL-FABP (13.50 [3.40-75.60] ng/ml) and uL-FABP/Cr (4.90 [0.97-2139.44] mu g/g) than healthy cats (4.25 [1.34-23.25] ng/ml; P = .01 and 0.46 [0.18-9.13] mu g/g; P < .001, respectively). Hyperthyroid cats at T0 had significantly higher uL-FABP/Cr (0.94 [0.15-896.00] mu g/g) than healthy cats (P < .001), thereafter uL-FABP/Cr significantly decreased at T2 (0.54 [0.10-76.41] mu g/g, P = .002). For the detection of CKD, uL-FABP/Cr had 100% (95% confidence interval [CI], 66.4-100.0) sensitivity and 93.2% (95% CI, 81.3-98.6) specificity. There were no significant differences in sNGAL and uNGAL/Cr between the 3 groups. Conclusions and Clinical Importance L-FABP, but not NGAL, is a potential biomarker for the detection of early CKD in cats. Utility of uL-FABP to predict azotemia after treatment in hyperthyroid cats remains unknown.
Keywords
biomarkers, cats, CKD, hyperthyroid, L&#8208, FABP, NGAL

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MLA
Kongtasai, Thirawut, et al. “Liver-Type Fatty Acid-Binding Protein and Neutrophil Gelatinase-Associated Lipocalin in Cats with Chronic Kidney Disease and Hyperthyroidism.” JOURNAL OF VETERINARY INTERNAL MEDICINE, vol. 35, no. 3, 2021, pp. 1376–88, doi:10.1111/jvim.16074.
APA
Kongtasai, T., Meyer, E., Paepe, D., Marynissen, S., Smets, P., Mortier, F., … Daminet, S. (2021). Liver-type fatty acid-binding protein and neutrophil gelatinase-associated lipocalin in cats with chronic kidney disease and hyperthyroidism. JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1376–1388. https://doi.org/10.1111/jvim.16074
Chicago author-date
Kongtasai, Thirawut, Evelyne Meyer, Dominique Paepe, Sofie Marynissen, Pascale Smets, Femke Mortier, Kristel Demeyere, et al. 2021. “Liver-Type Fatty Acid-Binding Protein and Neutrophil Gelatinase-Associated Lipocalin in Cats with Chronic Kidney Disease and Hyperthyroidism.” JOURNAL OF VETERINARY INTERNAL MEDICINE 35 (3): 1376–88. https://doi.org/10.1111/jvim.16074.
Chicago author-date (all authors)
Kongtasai, Thirawut, Evelyne Meyer, Dominique Paepe, Sofie Marynissen, Pascale Smets, Femke Mortier, Kristel Demeyere, Eva Vandermeulen, Emmelie Stock, Eva Buresova, Pieter Defauw, Luc Duchateau, and Sylvie Daminet. 2021. “Liver-Type Fatty Acid-Binding Protein and Neutrophil Gelatinase-Associated Lipocalin in Cats with Chronic Kidney Disease and Hyperthyroidism.” JOURNAL OF VETERINARY INTERNAL MEDICINE 35 (3): 1376–1388. doi:10.1111/jvim.16074.
Vancouver
1.
Kongtasai T, Meyer E, Paepe D, Marynissen S, Smets P, Mortier F, et al. Liver-type fatty acid-binding protein and neutrophil gelatinase-associated lipocalin in cats with chronic kidney disease and hyperthyroidism. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2021;35(3):1376–88.
IEEE
[1]
T. Kongtasai et al., “Liver-type fatty acid-binding protein and neutrophil gelatinase-associated lipocalin in cats with chronic kidney disease and hyperthyroidism,” JOURNAL OF VETERINARY INTERNAL MEDICINE, vol. 35, no. 3, pp. 1376–1388, 2021.
@article{8704999,
  abstract     = {{Background Liver-type fatty acid-binding protein (L-FABP) and neutrophil gelatinase-associated lipocalin (NGAL) are candidate biomarkers for the detection of early chronic kidney disease (CKD) in cats.

Objective To evaluate urinary and serum L-FABP and NGAL concentrations in CKD cats and in hyperthyroid cats before and after radioiodine (I-131) treatment.

Animals Nine CKD cats, 45 healthy cats and hyperthyroid cats at 3 time points including before (T0, n = 49), 1 month (T1, n = 49), and 11 to 29 months after (T2, n = 26) I-131 treatment.

Methods Cross-sectional and longitudinal study. Serum L-FABP (sL-FABP), serum NGAL (sNGAL), urinary L-FABP (uL-FABP), and urinary NGAL (uNGAL) were compared between the 3 groups and between hyperthyroid cats before and after treatment. Data are reported as median (min-max).

Results CKD cats had significantly higher sL-FABP (13.50 [3.40-75.60] ng/ml) and uL-FABP/Cr (4.90 [0.97-2139.44] mu g/g) than healthy cats (4.25 [1.34-23.25] ng/ml; P = .01 and 0.46 [0.18-9.13] mu g/g; P < .001, respectively). Hyperthyroid cats at T0 had significantly higher uL-FABP/Cr (0.94 [0.15-896.00] mu g/g) than healthy cats (P < .001), thereafter uL-FABP/Cr significantly decreased at T2 (0.54 [0.10-76.41] mu g/g, P = .002). For the detection of CKD, uL-FABP/Cr had 100% (95% confidence interval [CI], 66.4-100.0) sensitivity and 93.2% (95% CI, 81.3-98.6) specificity. There were no significant differences in sNGAL and uNGAL/Cr between the 3 groups.

Conclusions and Clinical Importance L-FABP, but not NGAL, is a potential biomarker for the detection of early CKD in cats. Utility of uL-FABP to predict azotemia after treatment in hyperthyroid cats remains unknown.}},
  author       = {{Kongtasai, Thirawut and Meyer, Evelyne and Paepe, Dominique and Marynissen, Sofie and Smets, Pascale and Mortier, Femke and Demeyere, Kristel and Vandermeulen, Eva and Stock, Emmelie and Buresova, Eva and Defauw, Pieter and Duchateau, Luc and Daminet, Sylvie}},
  issn         = {{0891-6640}},
  journal      = {{JOURNAL OF VETERINARY INTERNAL MEDICINE}},
  keywords     = {{biomarkers,cats,CKD,hyperthyroid,L&#8208,FABP,NGAL}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1376--1388}},
  title        = {{Liver-type fatty acid-binding protein and neutrophil gelatinase-associated lipocalin in cats with chronic kidney disease and hyperthyroidism}},
  url          = {{http://dx.doi.org/10.1111/jvim.16074}},
  volume       = {{35}},
  year         = {{2021}},
}

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