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Polymer architecture as key to unprecedented high-resolution 3D-printing performance : the case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone

(2021) MATERIALS TODAY. 44. p.25-39
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Abstract
Two-photon polymerization (2PP) is a high-resolution 3D-printing technology with a very rapidly expanding field of applications, including tissue engineering (TE). In this field, 2PP offers unprecedented possibilities for systematic studies of both cell–cell and cell–material interactions in 3D. For TE applications, the reliable production of biodegradable micro-scaffolds in porous, complex architectures is essential. However, the number of biodegradable materials that support the required level of spatial resolution is very limited, being a major bottleneck for the use of 2PP in the TE field. Herein, we introduce a hexa-functional urethane-based biodegradable precursor that overcomes the limitations associated with the high-resolution printing of current biodegradable precursors. The precursor is a telechelic urethane-based poly-ε-caprolactone (PCL) possessing three acrylate functionalities at each polymer end group which enables the reliable production of complex architectures owing to its superior physical properties as compared to the traditional di-acrylate terminated analogs. The newly developed hexa-functional telechelic urethane-based PCL reveals enhanced crosslinking kinetics and one order of magnitude higher Young’s modulus compared to the di-functional precursor (57.8 versus 6.3 MPa), providing an efficient and solvent-free 2PP processing at fast scanning speeds of up to 100 mm s−1 with unprecedented feature resolutions (143 ± 18 nm at 100 mm s−1 scanning speed). The crosslinked hexa-functional polymer combines strength and flexibility owing to the segregation between its hard polyacrylate and soft PCL segments, which makes it suitable for biological systems in contrast to the highly crosslinked and rigid structures typically manufactured by 2PP. Furthermore, it revealed lower degradation rate compared to its di-functional analog, which can be considered as an advantage in terms of biocompatibility due to the slower formation of acidic degradation products. Extracts of the developed polymers did not show a cytotoxic effect on the L929 fibroblasts as confirmed via ISO 10993-5 standard protocol. The presented precursor design constitutes a simple and effective approach that can be easily translated towards other biodegradable polymers for the manufacturing of biodegradable constructs with nano-scale precision, offering for the first time to use the true capabilities of 2PP for TE applications with the use of synthetic biodegradable polymers.
Keywords
2-PHOTON POLYMERIZATION, MECHANICAL-PROPERTIES, BIOCOMPATIBLE PHOTOPOLYMERS, PATTERN COLLAPSE, TISSUE, FABRICATION, SCAFFOLDS, ACRYLATES, KINETICS, POLYESTERS

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MLA
Arslan, Aysu, et al. “Polymer Architecture as Key to Unprecedented High-Resolution 3D-Printing Performance : The Case of Biodegradable Hexa-Functional Telechelic Urethane-Based Poly-ε-Caprolactone.” MATERIALS TODAY, vol. 44, 2021, pp. 25–39, doi:10.1016/j.mattod.2020.10.005.
APA
Arslan, A., Steiger, W., Roose, P., Van den Bergen, H., Gruber, P., Zerobin, E., … Dubruel, P. (2021). Polymer architecture as key to unprecedented high-resolution 3D-printing performance : the case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone. MATERIALS TODAY, 44, 25–39. https://doi.org/10.1016/j.mattod.2020.10.005
Chicago author-date
Arslan, Aysu, Wolfgang Steiger, Patrice Roose, Hugues Van den Bergen, Peter Gruber, Elise Zerobin, Franziska Gantner, et al. 2021. “Polymer Architecture as Key to Unprecedented High-Resolution 3D-Printing Performance : The Case of Biodegradable Hexa-Functional Telechelic Urethane-Based Poly-ε-Caprolactone.” MATERIALS TODAY 44: 25–39. https://doi.org/10.1016/j.mattod.2020.10.005.
Chicago author-date (all authors)
Arslan, Aysu, Wolfgang Steiger, Patrice Roose, Hugues Van den Bergen, Peter Gruber, Elise Zerobin, Franziska Gantner, Olivier Guillaume, Aleksandr Ovsianikov, Sandra Van Vlierberghe, and Peter Dubruel. 2021. “Polymer Architecture as Key to Unprecedented High-Resolution 3D-Printing Performance : The Case of Biodegradable Hexa-Functional Telechelic Urethane-Based Poly-ε-Caprolactone.” MATERIALS TODAY 44: 25–39. doi:10.1016/j.mattod.2020.10.005.
Vancouver
1.
Arslan A, Steiger W, Roose P, Van den Bergen H, Gruber P, Zerobin E, et al. Polymer architecture as key to unprecedented high-resolution 3D-printing performance : the case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone. MATERIALS TODAY. 2021;44:25–39.
IEEE
[1]
A. Arslan et al., “Polymer architecture as key to unprecedented high-resolution 3D-printing performance : the case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone,” MATERIALS TODAY, vol. 44, pp. 25–39, 2021.
@article{8704568,
  abstract     = {{Two-photon polymerization (2PP) is a high-resolution 3D-printing technology with a very rapidly expanding field of applications, including tissue engineering (TE). In this field, 2PP offers unprecedented possibilities for systematic studies of both cell–cell and cell–material interactions in 3D. For TE applications, the reliable production of biodegradable micro-scaffolds in porous, complex architectures is essential. However, the number of biodegradable materials that support the required level of spatial resolution is very limited, being a major bottleneck for the use of 2PP in the TE field.

Herein, we introduce a hexa-functional urethane-based biodegradable precursor that overcomes the limitations associated with the high-resolution printing of current biodegradable precursors. The precursor is a telechelic urethane-based poly-ε-caprolactone (PCL) possessing three acrylate functionalities at each polymer end group which enables the reliable production of complex architectures owing to its superior physical properties as compared to the traditional di-acrylate terminated analogs. The newly developed hexa-functional telechelic urethane-based PCL reveals enhanced crosslinking kinetics and one order of magnitude higher Young’s modulus compared to the di-functional precursor (57.8 versus 6.3 MPa), providing an efficient and solvent-free 2PP processing at fast scanning speeds of up to 100 mm s−1 with unprecedented feature resolutions (143 ± 18 nm at 100 mm s−1 scanning speed). The crosslinked hexa-functional polymer combines strength and flexibility owing to the segregation between its hard polyacrylate and soft PCL segments, which makes it suitable for biological systems in contrast to the highly crosslinked and rigid structures typically manufactured by 2PP. Furthermore, it revealed lower degradation rate compared to its di-functional analog, which can be considered as an advantage in terms of biocompatibility due to the slower formation of acidic degradation products. Extracts of the developed polymers did not show a cytotoxic effect on the L929 fibroblasts as confirmed via ISO 10993-5 standard protocol. The presented precursor design constitutes a simple and effective approach that can be easily translated towards other biodegradable polymers for the manufacturing of biodegradable constructs with nano-scale precision, offering for the first time to use the true capabilities of 2PP for TE applications with the use of synthetic biodegradable polymers.}},
  author       = {{Arslan, Aysu and Steiger, Wolfgang and Roose, Patrice and Van den Bergen, Hugues and Gruber, Peter and Zerobin, Elise and Gantner, Franziska and Guillaume, Olivier and Ovsianikov, Aleksandr and Van Vlierberghe, Sandra and Dubruel, Peter}},
  issn         = {{1369-7021}},
  journal      = {{MATERIALS TODAY}},
  keywords     = {{2-PHOTON POLYMERIZATION,MECHANICAL-PROPERTIES,BIOCOMPATIBLE PHOTOPOLYMERS,PATTERN COLLAPSE,TISSUE,FABRICATION,SCAFFOLDS,ACRYLATES,KINETICS,POLYESTERS}},
  language     = {{eng}},
  pages        = {{25--39}},
  title        = {{Polymer architecture as key to unprecedented high-resolution 3D-printing performance : the case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone}},
  url          = {{http://dx.doi.org/10.1016/j.mattod.2020.10.005}},
  volume       = {{44}},
  year         = {{2021}},
}

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