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Abstract
Older adults, especially men and/or those with diabetes, hypertension and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritised to receive COVID-19 vaccines due to high risk of death. In very rare instances,the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society)Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.
Keywords
COVID-19 vaccines, anaphylaxis, older (adults/people), adrenaline

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MLA
Bousquet, Jean, et al. “Management of Anaphylaxis Due to COVID‐19 Vaccines in the Elderly.” Allergy, 2021, doi:10.1111/all.14838.
APA
Bousquet, J., Agache, I., Blain, H., Jutel, M., Ventura, M. T., Worm, M., … Klimek, L. (2021). Management of anaphylaxis due to COVID‐19 vaccines in the elderly. Allergy. https://doi.org/10.1111/all.14838
Chicago author-date
Bousquet, Jean, Ioana Agache, Hubert Blain, Marek Jutel, Maria Teresa Ventura, Margitta Worm, Stefano Del Giacco, et al. 2021. “Management of Anaphylaxis Due to COVID‐19 Vaccines in the Elderly.” Allergy. https://doi.org/10.1111/all.14838.
Chicago author-date (all authors)
Bousquet, Jean, Ioana Agache, Hubert Blain, Marek Jutel, Maria Teresa Ventura, Margitta Worm, Stefano Del Giacco, Athanasios Benetos, Maria Beatrice Bilo, Wienczyslawa Czarlewski, Amir Hamzah Abdul Latiff, Mona Al‐Ahmad, Elizabeth Angier, Isabella Annesi‐Maesano, Marina Atanaskovic‐Markovic, Claus Bachert, Annick Barbaud, Anna Bedbrook, Kazi S. Bennoor, Elena Camelia Berghea, Carsten Bindslev‐Jensen, Sergio Bonini, Sinthia Bosnic‐Anticevich, Knut Brockow, Luisa Brussino, Paulo Camargos, G Walter Canonica, Victoria Cardona, Pedro Carreiro‐Martins, Ana Carriazo, Thomas Casale, Jean‐Christoph Caubet, Lorenzo Cecchi, Antonio Cherubini, George Christoff, Derek K. Chu, Alvaro A. Cruz, Dejan Dokic, Yehia El‐Gamal, Motohiro Ebisawa, Bernadette Eberlein, John Farrell, Montserrat Fernandez‐Rivas, Wytske J. Fokkens, Joao A. Fonseca, Yadong Gao, Gaëtan Gavazzi, Radolslaw Gawlik, Asli Gelincik, Bilun Gemicioğlu, Maia Gotua, Olivier Guérin, Tari Haahtela, Karin Hoffmann‐Sommergruber, Hans Jürgen Hoffmann, Maja Hofmann, Martin Hrubisko, Madda lenaIllario, Carla Irani, Zhanat Ispayeva, Juan Carlos Ivancevich, Kaja Julge, Igor Kaidashev, Musa Khaitov, Edward Knol, Helga Kraxner, Piotr Kuna, Violeta Kvedariene, Antti Lauerma, Lan T.T. Le, Vincent Le Moing, Michael Levin, Renaud Louis, Olga Lourenco, Vera Mahler, Finbarr C. Martin, Andrea Matucci, Branislava Milenkovic, Stéphanie Miot, Emma Montella, Mario Morais‐Almeida, Charlotte G Mortz, Joaquim Mullol, Leyla Namazova‐Baranova, Hugo Neffen, Kristof Nekam, Marek Niedoszytko, Mikaëla Odemyr, Robyn E O’Hehir, Yoshitaka Okamoto, Markus Ollert, Oscar Palomares, Nikolaos G. Papadopoulos, Petr Panzner, Gianni Passalacqua, Vincenzo Patella, Mirko Petrovic, Oliver Pfaar, Nhân Pham‐Thi, Davor Plavec, Todor A. Popov, Marysia T. Recto, Frederico S. Regateiro, Jacques Reynes, Regina E. Roller‐Winsberger, Yves Rolland, Antonino Romano, Carmen Rondon, Menachem Rottem, Philip W. Rouadi, Nathalie Salles, Boleslaw Samolinski, Alexandra F. Santos, Faradiba Sarquis Serpa, Joaquin Sastre, Jos M.G.A. Schols, Nicola Scichilone, Anna Sediva, Mohamed H. Shamji, Aziz Sheikh, Isabel Skypala, Sylwia Smolinska, Milena Sokolowska, Bernardo Sousa‐Pinto, Milan Sova, Rafael Stelmach, Gunter Sturm, Charlotte Suppli Ulrik, Ana Maria Todo‐Bom, Sanna Toppila‐Salmi, Ioanna Tsiligianni, Maria Torres, Eva Untersmayr, Marilyn Urrutia Pereira, Arunas Valiulis, Joana Vitte, Alessandra Vultaggio, Dana Wallace, Jolanta Walusiak‐Skorupa, De‐Yun Wang, Susan Waserman, Arzu Yorgancioglu, Osman M. Yusuf, Mario Zernotti, Mihaela Zidarn, Tomas Chivato, Cezmi A. Akdis, Torsten Zuberbier, and Ludger Klimek. 2021. “Management of Anaphylaxis Due to COVID‐19 Vaccines in the Elderly.” Allergy. doi:10.1111/all.14838.
Vancouver
1.
Bousquet J, Agache I, Blain H, Jutel M, Ventura MT, Worm M, et al. Management of anaphylaxis due to COVID‐19 vaccines in the elderly. Allergy. 2021;
IEEE
[1]
J. Bousquet et al., “Management of anaphylaxis due to COVID‐19 vaccines in the elderly,” Allergy, 2021.
@article{8703673,
  abstract     = {Older adults, especially men and/or those with diabetes, hypertension and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritised to receive COVID-19 vaccines due to high risk of death. In very rare instances,the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society)Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay
treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.},
  author       = {Bousquet, Jean and Agache, Ioana and Blain, Hubert and Jutel, Marek and Ventura, Maria Teresa and Worm, Margitta and Del Giacco, Stefano and Benetos, Athanasios and Bilo, Maria Beatrice and Czarlewski, Wienczyslawa and Abdul Latiff, Amir Hamzah and Al‐Ahmad, Mona and Angier, Elizabeth and Annesi‐Maesano, Isabella and Atanaskovic‐Markovic, Marina and Bachert, Claus and Barbaud, Annick and Bedbrook, Anna and Bennoor, Kazi S. and Berghea, Elena Camelia and Bindslev‐Jensen, Carsten and Bonini, Sergio and Bosnic‐Anticevich, Sinthia and Brockow, Knut and Brussino, Luisa and Camargos, Paulo and Canonica, G Walter and Cardona, Victoria and Carreiro‐Martins, Pedro and Carriazo, Ana and Casale, Thomas and Caubet, Jean‐Christoph and Cecchi, Lorenzo and Cherubini, Antonio and Christoff, George and Chu, Derek K. and Cruz, Alvaro A. and Dokic, Dejan and El‐Gamal, Yehia and Ebisawa, Motohiro and Eberlein, Bernadette and Farrell, John and Fernandez‐Rivas, Montserrat and Fokkens, Wytske J. and Fonseca, Joao A. and Gao, Yadong and Gavazzi, Gaëtan and Gawlik, Radolslaw and Gelincik, Asli and Gemicioğlu, Bilun and Gotua, Maia and Guérin, Olivier and Haahtela, Tari and Hoffmann‐Sommergruber, Karin and Hoffmann, Hans Jürgen and Hofmann, Maja and Hrubisko, Martin and lenaIllario, Madda and Irani, Carla and Ispayeva, Zhanat and Ivancevich, Juan Carlos and Julge, Kaja and Kaidashev, Igor and Khaitov, Musa and Knol, Edward and Kraxner, Helga and Kuna, Piotr and Kvedariene, Violeta and Lauerma, Antti and Le, Lan T.T. and Le Moing, Vincent and Levin, Michael and Louis, Renaud and Lourenco, Olga and Mahler, Vera and Martin, Finbarr C. and Matucci, Andrea and Milenkovic, Branislava and Miot, Stéphanie and Montella, Emma and Morais‐Almeida, Mario and Mortz, Charlotte G and Mullol, Joaquim and Namazova‐Baranova, Leyla and Neffen, Hugo and Nekam, Kristof and Niedoszytko, Marek and Odemyr, Mikaëla and O’Hehir, Robyn E and Okamoto, Yoshitaka and Ollert, Markus and Palomares, Oscar and Papadopoulos, Nikolaos G. and Panzner, Petr and Passalacqua, Gianni and Patella, Vincenzo and Petrovic, Mirko and Pfaar, Oliver and Pham‐Thi, Nhân and Plavec, Davor and Popov, Todor A. and Recto, Marysia T. and Regateiro, Frederico S. and Reynes, Jacques and Roller‐Winsberger, Regina E. and Rolland, Yves and Romano, Antonino and Rondon, Carmen and Rottem, Menachem and Rouadi, Philip W. and Salles, Nathalie and Samolinski, Boleslaw and Santos, Alexandra F. and Serpa, Faradiba Sarquis and Sastre, Joaquin and Schols, Jos M.G.A. and Scichilone, Nicola and Sediva, Anna and Shamji, Mohamed H. and Sheikh, Aziz and Skypala, Isabel and Smolinska, Sylwia and Sokolowska, Milena and Sousa‐Pinto, Bernardo and Sova, Milan and Stelmach, Rafael and Sturm, Gunter and Suppli Ulrik, Charlotte and Todo‐Bom, Ana Maria and Toppila‐Salmi, Sanna and Tsiligianni, Ioanna and Torres, Maria and Untersmayr, Eva and Urrutia Pereira, Marilyn and Valiulis, Arunas and Vitte, Joana and Vultaggio, Alessandra and Wallace, Dana and Walusiak‐Skorupa, Jolanta and Wang, De‐Yun and Waserman, Susan and Yorgancioglu, Arzu and Yusuf, Osman M. and Zernotti, Mario and Zidarn, Mihaela and Chivato, Tomas and Akdis, Cezmi A. and Zuberbier, Torsten and Klimek, Ludger},
  issn         = {0105-4538},
  journal      = {Allergy},
  keywords     = {COVID-19 vaccines,anaphylaxis,older (adults/people),adrenaline},
  language     = {eng},
  title        = {Management of anaphylaxis due to COVID‐19 vaccines in the elderly},
  url          = {http://dx.doi.org/10.1111/all.14838},
  year         = {2021},
}

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