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TwinssCan : gene-environment interaction in psychotic and depressive intermediate phenotypes : risk and protective factors in a general population twin sample

Lotta-Katrin Pries, Clara Snijders, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom (UGent) , Evert Thiery, et al.
(2019) TWIN RESEARCH AND HUMAN GENETICS. 22(6). p.460-466
Author
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Abstract
Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically measured using experimental paradigms that assess neurocognitive processes such as salience attribution, sensitivity to social defeat and reward sensitivity. Here, we describe the TwinssCan, a longitudinal general population twin cohort, which comprises 1202 individuals (796 adolescent/young adult twins, 43 siblings and 363 parents) at baseline. The TwinssCan is part of the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia project and recruited from the East Flanders Prospective Twin Survey. The main objective of this project is to understand psychopathology by evaluating the contribution of genetic and nongenetic factors on subclinical expressions of dimensional phenotypes at a young age before the onset of disorder and their association with neurocognitive processes, such as salience attribution, sensitivity to social defeat and reward sensitivity.
Keywords
Obstetrics and Gynaecology, Genetics(clinical), Pediatrics, Perinatology, and Child Health, Psychosis, depression, genetics, environment, salience attribution, social defeat, stress sensitivity, reward sensitivity, general population, twins, SUBCLINICAL PSYCHOSIS, CHILDHOOD TRAUMA, PEER EVALUATION, SURVEY EFPTS, SCHIZOPHRENIA, EXPERIENCES, VALIDATION, DISORDER, SENSITIVITY, RELIABILITY

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MLA
Pries, Lotta-Katrin, et al. “TwinssCan : Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes : Risk and Protective Factors in a General Population Twin Sample.” TWIN RESEARCH AND HUMAN GENETICS, vol. 22, no. 6, 2019, pp. 460–66, doi:10.1017/thg.2019.96.
APA
Pries, L.-K., Snijders, C., Menne-Lothmann, C., Decoster, J., van Winkel, R., Collip, D., … Rutten, B. P. F. (2019). TwinssCan : gene-environment interaction in psychotic and depressive intermediate phenotypes : risk and protective factors in a general population twin sample. TWIN RESEARCH AND HUMAN GENETICS, 22(6), 460–466. https://doi.org/10.1017/thg.2019.96
Chicago author-date
Pries, Lotta-Katrin, Clara Snijders, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, et al. 2019. “TwinssCan : Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes : Risk and Protective Factors in a General Population Twin Sample.” TWIN RESEARCH AND HUMAN GENETICS 22 (6): 460–66. https://doi.org/10.1017/thg.2019.96.
Chicago author-date (all authors)
Pries, Lotta-Katrin, Clara Snijders, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Sinan Guloksuz, Jim van Os, and Bart P. F. Rutten. 2019. “TwinssCan : Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes : Risk and Protective Factors in a General Population Twin Sample.” TWIN RESEARCH AND HUMAN GENETICS 22 (6): 460–466. doi:10.1017/thg.2019.96.
Vancouver
1.
Pries L-K, Snijders C, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, et al. TwinssCan : gene-environment interaction in psychotic and depressive intermediate phenotypes : risk and protective factors in a general population twin sample. TWIN RESEARCH AND HUMAN GENETICS. 2019;22(6):460–6.
IEEE
[1]
L.-K. Pries et al., “TwinssCan : gene-environment interaction in psychotic and depressive intermediate phenotypes : risk and protective factors in a general population twin sample,” TWIN RESEARCH AND HUMAN GENETICS, vol. 22, no. 6, pp. 460–466, 2019.
@article{8703495,
  abstract     = {{Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically measured using experimental paradigms that assess neurocognitive processes such as salience attribution, sensitivity to social defeat and reward sensitivity. Here, we describe the TwinssCan, a longitudinal general population twin cohort, which comprises 1202 individuals (796 adolescent/young adult twins, 43 siblings and 363 parents) at baseline. The TwinssCan is part of the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia project and recruited from the East Flanders Prospective Twin Survey. The main objective of this project is to understand psychopathology by evaluating the contribution of genetic and nongenetic factors on subclinical expressions of dimensional phenotypes at a young age before the onset of disorder and their association with neurocognitive processes, such as salience attribution, sensitivity to social defeat and reward sensitivity.}},
  articleno    = {{PII S1832427419000963}},
  author       = {{Pries, Lotta-Katrin and Snijders, Clara and Menne-Lothmann, Claudia and Decoster, Jeroen and van Winkel, Ruud and Collip, Dina and Delespaul, Philippe and De Hert, Marc and Derom, Catherine and Thiery, Evert and Jacobs, Nele and Wichers, Marieke and Guloksuz, Sinan and van Os, Jim and Rutten, Bart P. F.}},
  issn         = {{1832-4274}},
  journal      = {{TWIN RESEARCH AND HUMAN GENETICS}},
  keywords     = {{Obstetrics and Gynaecology,Genetics(clinical),Pediatrics,Perinatology,and Child Health,Psychosis,depression,genetics,environment,salience attribution,social defeat,stress sensitivity,reward sensitivity,general population,twins,SUBCLINICAL PSYCHOSIS,CHILDHOOD TRAUMA,PEER EVALUATION,SURVEY EFPTS,SCHIZOPHRENIA,EXPERIENCES,VALIDATION,DISORDER,SENSITIVITY,RELIABILITY}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{PII S1832427419000963:460--PII S1832427419000963:466}},
  title        = {{TwinssCan : gene-environment interaction in psychotic and depressive intermediate phenotypes : risk and protective factors in a general population twin sample}},
  url          = {{http://doi.org/10.1017/thg.2019.96}},
  volume       = {{22}},
  year         = {{2019}},
}
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