Advanced search
1 file | 2.20 MB Add to list

Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Author
Organization
Abstract
Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.
Keywords
Multidisciplinary, GENOME-WIDE ASSOCIATION, MATERNAL EDUCATION, TWINS, GROWTH, HERITABILITY, CHILDREN, PROJECT, LOCI

Downloads

  • published.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 2.20 MB

Citation

Please use this url to cite or link to this publication:

MLA
Jelenkovic, Aline, et al. “Genetic and Environmental Influences on Human Height from Infancy through Adulthood at Different Levels of Parental Education.” SCIENTIFIC REPORTS, vol. 10, no. 1, 2020, doi:10.1038/s41598-020-64883-8.
APA
Jelenkovic, A., Sund, R., Yokoyama, Y., Latvala, A., Sugawara, M., Tanaka, M., … Silventoinen, K. (2020). Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. SCIENTIFIC REPORTS, 10(1). https://doi.org/10.1038/s41598-020-64883-8
Chicago author-date
Jelenkovic, Aline, Reijo Sund, Yoshie Yokoyama, Antti Latvala, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, et al. 2020. “Genetic and Environmental Influences on Human Height from Infancy through Adulthood at Different Levels of Parental Education.” SCIENTIFIC REPORTS 10 (1). https://doi.org/10.1038/s41598-020-64883-8.
Chicago author-date (all authors)
Jelenkovic, Aline, Reijo Sund, Yoshie Yokoyama, Antti Latvala, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Duarte L. Freitas, José Antonio Maia, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Kimberly J. Saudino, Tessa L. Cutler, John L. Hopper, Vilhelmina Ullemar, Catarina Almqvist, Patrik K. E. Magnusson, Wendy Cozen, Amie E. Hwang, Thomas M. Mack, Tracy L. Nelson, Keith E. Whitfield, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Clare H. Llewellyn, Abigail Fisher, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Laura A. Baker, Catherine Tuvblad, Robin P. Corley, Brooke M. Huibregtse, Catherine Derom, Robert F. Vlietinck, Ruth J. F. Loos, S. Alexandra Burt, Kelly L. Klump, Judy L. Silberg, Hermine H. Maes, Robert F. Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A. Butler, Jennifer R. Harris, Ingunn Brandt, Thomas S. Nilsen, K. Paige Harden, Elliot M. Tucker-Drob, Carol E. Franz, William S. Kremen, Michael J. Lyons, Paul Lichtenstein, Meike Bartels, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Sevgi Y. Öncel, Fazil Aliev, Hoe-Uk Jeong, Yoon-Mi Hur, Eric Turkheimer, Dorret I. Boomsma, Thorkild I. A. Sørensen, Jaakko Kaprio, and Karri Silventoinen. 2020. “Genetic and Environmental Influences on Human Height from Infancy through Adulthood at Different Levels of Parental Education.” SCIENTIFIC REPORTS 10 (1). doi:10.1038/s41598-020-64883-8.
Vancouver
1.
Jelenkovic A, Sund R, Yokoyama Y, Latvala A, Sugawara M, Tanaka M, et al. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. SCIENTIFIC REPORTS. 2020;10(1).
IEEE
[1]
A. Jelenkovic et al., “Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education,” SCIENTIFIC REPORTS, vol. 10, no. 1, 2020.
@article{8703490,
  abstract     = {{Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.}},
  articleno    = {{7974}},
  author       = {{Jelenkovic, Aline and Sund, Reijo and Yokoyama, Yoshie and Latvala, Antti and Sugawara, Masumi and Tanaka, Mami and Matsumoto, Satoko and Freitas, Duarte L. and Maia, José Antonio and Knafo-Noam, Ariel and Mankuta, David and Abramson, Lior and Ji, Fuling and Ning, Feng and Pang, Zengchang and Rebato, Esther and Saudino, Kimberly J. and Cutler, Tessa L. and Hopper, John L. and Ullemar, Vilhelmina and Almqvist, Catarina and Magnusson, Patrik K. E. and Cozen, Wendy and Hwang, Amie E. and Mack, Thomas M. and Nelson, Tracy L. and Whitfield, Keith E. and Sung, Joohon and Kim, Jina and Lee, Jooyeon and Lee, Sooji and Llewellyn, Clare H. and Fisher, Abigail and Medda, Emanuela and Nisticò, Lorenza and Toccaceli, Virgilia and Baker, Laura A. and Tuvblad, Catherine and Corley, Robin P. and Huibregtse, Brooke M. and Derom, Catherine and Vlietinck, Robert F. and Loos, Ruth J. F. and Burt, S. Alexandra and Klump, Kelly L. and Silberg, Judy L. and Maes, Hermine H. and Krueger, Robert F. and McGue, Matt and Pahlen, Shandell and Gatz, Margaret and Butler, David A. and Harris, Jennifer R. and Brandt, Ingunn and Nilsen, Thomas S. and Harden, K. Paige and Tucker-Drob, Elliot M. and Franz, Carol E. and Kremen, William S. and Lyons, Michael J. and Lichtenstein, Paul and Bartels, Meike and Beijsterveldt, Catharina E. M. van and Willemsen, Gonneke and Öncel, Sevgi Y. and Aliev, Fazil and Jeong, Hoe-Uk and Hur, Yoon-Mi and Turkheimer, Eric and Boomsma, Dorret I. and Sørensen, Thorkild I. A. and Kaprio, Jaakko and Silventoinen, Karri}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{Multidisciplinary,GENOME-WIDE ASSOCIATION,MATERNAL EDUCATION,TWINS,GROWTH,HERITABILITY,CHILDREN,PROJECT,LOCI}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education}},
  url          = {{http://dx.doi.org/10.1038/s41598-020-64883-8}},
  volume       = {{10}},
  year         = {{2020}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: