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Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score

(2020) PLOS ONE. 15(6).
Author
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Abstract
Objective To evaluate prevalence of structural lesions, synovitis and bone marrow lesions (BMLs) on MRI performed with a 0.3T imaging system in patients with erosive hand osteoarthritis (EHOA) and to compare them to the anatomic radiographic Verbruggen-Veys score (VV). Design For this Cross-sectional study, fifty-five EHOA patients were studied with 0.3T contrast-enhanced MRI and radiography (RX) of their dominant hand. Structural lesions were scored according to the OMERACT Hand Osteoarthritis MRI Scoring System as follows: osteophytes and erosions were graded from 0 to 3. On joint destruction lesion synovitis and BMLs were graded from 0 to 1. And on MRI, we evaluated the presence of several structural features: N: normal, O: osteophytic lesions, E: erosive lesions, E/O: osteophytic and erosive lesions and D: joint destruction. RX was scored according to the VV system. Relations between MRI features and VV stages were analysed. Results MRI identified more structural lesions than RX (77.3% versus 74.8%) and particularly more erosive lesions (E or E/O) than VV Phase E (33.5% versus 20.2%). E/O and D were mostly found on MRI. Synovitis and BMLs were significantly associated with E/O and D with the following odds ratios (ORs): 8.4 (95% CI 1.8-13.6); OR: 13.7 (95% CI 2.9-21.0); OR: 15.7 (95% CI 3.2-23.5); OR: 38.5 (95% CI 9.5-57.0), respectively. Conclusion MRI 0.3T appears completely relevant for EHOA lesion analysis. First, MRI shows more erosive lesions than RX in EHOA; second, it allows for the analysis of synovitis and BMLs to be associated with more specific structural MRI features (E/O and D).
Keywords
RADIOLOGICAL ASSESSMENT, RELIABILITY, ARTHRITIS, FEATURES, RECOMMENDATIONS, ASSOCIATIONS, SENSITIVITY, PROGRESSION, MANAGEMENT

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MLA
Allado, Edem, et al. “Assessment of Structural Lesions, Synovitis and Bone Marrow Lesions in Erosive Hand Osteoarthritis on MRI (0.3T) Compared to the Radiographic Anatomical Verbruggen-Veys Score.” PLOS ONE, vol. 15, no. 6, 2020, doi:10.1371/journal.pone.0234972.
APA
Allado, E., Wittoek, R., Ferrero, S., Albuisson, E., Chary-Valckenaere, I., Roux, C., & Loeuille, D. (2020). Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score. PLOS ONE, 15(6). https://doi.org/10.1371/journal.pone.0234972
Chicago author-date
Allado, Edem, Ruth Wittoek, Stephanie Ferrero, Eliane Albuisson, Isabelle Chary-Valckenaere, Christian Roux, and Damien Loeuille. 2020. “Assessment of Structural Lesions, Synovitis and Bone Marrow Lesions in Erosive Hand Osteoarthritis on MRI (0.3T) Compared to the Radiographic Anatomical Verbruggen-Veys Score.” PLOS ONE 15 (6). https://doi.org/10.1371/journal.pone.0234972.
Chicago author-date (all authors)
Allado, Edem, Ruth Wittoek, Stephanie Ferrero, Eliane Albuisson, Isabelle Chary-Valckenaere, Christian Roux, and Damien Loeuille. 2020. “Assessment of Structural Lesions, Synovitis and Bone Marrow Lesions in Erosive Hand Osteoarthritis on MRI (0.3T) Compared to the Radiographic Anatomical Verbruggen-Veys Score.” PLOS ONE 15 (6). doi:10.1371/journal.pone.0234972.
Vancouver
1.
Allado E, Wittoek R, Ferrero S, Albuisson E, Chary-Valckenaere I, Roux C, et al. Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score. PLOS ONE. 2020;15(6).
IEEE
[1]
E. Allado et al., “Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score,” PLOS ONE, vol. 15, no. 6, 2020.
@article{8703488,
  abstract     = {{Objective To evaluate prevalence of structural lesions, synovitis and bone marrow lesions (BMLs) on MRI performed with a 0.3T imaging system in patients with erosive hand osteoarthritis (EHOA) and to compare them to the anatomic radiographic Verbruggen-Veys score (VV). Design For this Cross-sectional study, fifty-five EHOA patients were studied with 0.3T contrast-enhanced MRI and radiography (RX) of their dominant hand. Structural lesions were scored according to the OMERACT Hand Osteoarthritis MRI Scoring System as follows: osteophytes and erosions were graded from 0 to 3. On joint destruction lesion synovitis and BMLs were graded from 0 to 1. And on MRI, we evaluated the presence of several structural features: N: normal, O: osteophytic lesions, E: erosive lesions, E/O: osteophytic and erosive lesions and D: joint destruction. RX was scored according to the VV system. Relations between MRI features and VV stages were analysed. Results MRI identified more structural lesions than RX (77.3% versus 74.8%) and particularly more erosive lesions (E or E/O) than VV Phase E (33.5% versus 20.2%). E/O and D were mostly found on MRI. Synovitis and BMLs were significantly associated with E/O and D with the following odds ratios (ORs): 8.4 (95% CI 1.8-13.6); OR: 13.7 (95% CI 2.9-21.0); OR: 15.7 (95% CI 3.2-23.5); OR: 38.5 (95% CI 9.5-57.0), respectively. Conclusion MRI 0.3T appears completely relevant for EHOA lesion analysis. First, MRI shows more erosive lesions than RX in EHOA; second, it allows for the analysis of synovitis and BMLs to be associated with more specific structural MRI features (E/O and D).}},
  articleno    = {{e0234972}},
  author       = {{Allado, Edem and Wittoek, Ruth and Ferrero, Stephanie and Albuisson, Eliane and Chary-Valckenaere, Isabelle and Roux, Christian and Loeuille, Damien}},
  issn         = {{1932-6203}},
  journal      = {{PLOS ONE}},
  keywords     = {{RADIOLOGICAL ASSESSMENT,RELIABILITY,ARTHRITIS,FEATURES,RECOMMENDATIONS,ASSOCIATIONS,SENSITIVITY,PROGRESSION,MANAGEMENT}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{13}},
  title        = {{Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score}},
  url          = {{http://doi.org/10.1371/journal.pone.0234972}},
  volume       = {{15}},
  year         = {{2020}},
}

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