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Signed reward prediction errors in the ventral striatum drive episodic memory

Cristian Buc Calderon (UGent) , Esther De Loof (UGent) , Kate Ergo (UGent) , Anna Snoeck (UGent) , Nico Böhler (UGent) and Tom Verguts (UGent)
(2021) JOURNAL OF NEUROSCIENCE. 41(8). p.1716-1726
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Abstract
Recent behavioral evidence implicates reward prediction errors (RPEs) as a key factor in the acquisition of episodic memory. Yet, important neural predictions related to the role of RPEs in episodic memory acquisition remain to be tested. Humans (both sexes) performed a novel variable-choice task where we experimentally manipulated RPEs and found support for key neural predictions with fMRI. Our results show that in line with previous behavioral observations, episodic memory accuracy increases with the magnitude of signed (i.e., better/worse-than-expected) RPEs (SRPEs). Neurally, we observe that SRPEs are encoded in the ventral striatum (VS). Crucially, we demonstrate through mediation analysis that activation in the VS mediates the experimental manipulation of SRPEs on episodic memory accuracy. In particular, SRPE-based responses in the VS (during learning) predict the strength of subsequent episodic memory (during recollection). Furthermore, functional connectivity between task-relevant processing areas (i.e., face-selective areas) and hippocampus and ventral striatum increased as a function of RPE value (during learning), suggesting a central role of these areas in episodic memory formation. Our results consolidate reinforcement learning theory and striatal RPEs as key factors subtending the formation of episodic memory.
Keywords
episodic memory, fMRI, reward prediction error, ventral striatum, THETA OSCILLATIONS, ACTIVATION, SIGNALS, FMRI, GLUE

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MLA
Buc Calderon, Cristian, et al. “Signed Reward Prediction Errors in the Ventral Striatum Drive Episodic Memory.” JOURNAL OF NEUROSCIENCE, vol. 41, no. 8, 2021, pp. 1716–26, doi:10.1523/JNEUROSCI.1785-20.2020.
APA
Buc Calderon, C., De Loof, E., Ergo, K., Snoeck, A., Böhler, N., & Verguts, T. (2021). Signed reward prediction errors in the ventral striatum drive episodic memory. JOURNAL OF NEUROSCIENCE, 41(8), 1716–1726. https://doi.org/10.1523/JNEUROSCI.1785-20.2020
Chicago author-date
Buc Calderon, Cristian, Esther De Loof, Kate Ergo, Anna Snoeck, Nico Böhler, and Tom Verguts. 2021. “Signed Reward Prediction Errors in the Ventral Striatum Drive Episodic Memory.” JOURNAL OF NEUROSCIENCE 41 (8): 1716–26. https://doi.org/10.1523/JNEUROSCI.1785-20.2020.
Chicago author-date (all authors)
Buc Calderon, Cristian, Esther De Loof, Kate Ergo, Anna Snoeck, Nico Böhler, and Tom Verguts. 2021. “Signed Reward Prediction Errors in the Ventral Striatum Drive Episodic Memory.” JOURNAL OF NEUROSCIENCE 41 (8): 1716–1726. doi:10.1523/JNEUROSCI.1785-20.2020.
Vancouver
1.
Buc Calderon C, De Loof E, Ergo K, Snoeck A, Böhler N, Verguts T. Signed reward prediction errors in the ventral striatum drive episodic memory. JOURNAL OF NEUROSCIENCE. 2021;41(8):1716–26.
IEEE
[1]
C. Buc Calderon, E. De Loof, K. Ergo, A. Snoeck, N. Böhler, and T. Verguts, “Signed reward prediction errors in the ventral striatum drive episodic memory,” JOURNAL OF NEUROSCIENCE, vol. 41, no. 8, pp. 1716–1726, 2021.
@article{8702063,
  abstract     = {{Recent behavioral evidence implicates reward prediction errors (RPEs) as a key factor in the acquisition of episodic memory. Yet, important neural predictions related to the role of RPEs in episodic memory acquisition remain to be tested. Humans (both sexes) performed a novel variable-choice task where we experimentally manipulated RPEs and found support for key neural predictions with fMRI. Our results show that in line with previous behavioral observations, episodic memory accuracy increases with the magnitude of signed (i.e., better/worse-than-expected) RPEs (SRPEs). Neurally, we observe that SRPEs are encoded in the ventral striatum (VS). Crucially, we demonstrate through mediation analysis that activation in the VS mediates the experimental manipulation of SRPEs on episodic memory accuracy. In particular, SRPE-based responses in the VS (during learning) predict the strength of subsequent episodic memory (during recollection). Furthermore, functional connectivity between task-relevant processing areas (i.e., face-selective areas) and hippocampus and ventral striatum increased as a function of RPE value (during learning), suggesting a central role of these areas in episodic memory formation. Our results consolidate reinforcement learning theory and striatal RPEs as key factors subtending the formation of episodic memory.}},
  author       = {{Buc Calderon, Cristian and De Loof, Esther and Ergo, Kate and Snoeck, Anna and Böhler, Nico and Verguts, Tom}},
  issn         = {{0270-6474}},
  journal      = {{JOURNAL OF NEUROSCIENCE}},
  keywords     = {{episodic memory,fMRI,reward prediction error,ventral striatum,THETA OSCILLATIONS,ACTIVATION,SIGNALS,FMRI,GLUE}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1716--1726}},
  title        = {{Signed reward prediction errors in the ventral striatum drive episodic memory}},
  url          = {{http://dx.doi.org/10.1523/JNEUROSCI.1785-20.2020}},
  volume       = {{41}},
  year         = {{2021}},
}

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