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The effect of Parkinson's disease on otoacoustic emissions and efferent suppression of transient evoked otoacoustic emissions

Evelien De Groote (UGent) , Annelies Bockstael (UGent) , Dick Botteldooren (UGent) , Patrick Santens (UGent) and Miet De Letter (UGent)
Author
Organization
Abstract
Purpose Several studies have demonstrated increased auditory thresholds in patients with Parkinson's disease (PD) based on subjective tonal audiometry. However, the pathophysiological mechanisms underlying auditory dysfunction in PD remain elusive. The primary aim of this study was to investigate cochlear and olivocochlear function in PD using objective measurements and to assess the effect of dopaminergic medication on auditory function. Method Eighteen patients with PD and 18 gender- and age-matched healthy controls (HCs) were included. Patients with PD participated in medication on and off conditions. Linear mixed models were used to determine the effect of PD on tonal audiometry, transient evoked and distortion product otoacoustic emissions (OAEs), and efferent suppression (ES). Results Tonal audiometry revealed normal auditory thresholds in patients with PD for their age across all frequencies. OAE signal amplitudes demonstrated a significant interaction effect between group (PD vs. HC) and frequency, indicating decreased OAEs at low frequencies and increased OAEs at high frequencies in patients with PD. No significant differences were found between patients with PD and HCs regarding ES. In addition, no significant effect of medication status was found on auditory measurements in patients with PD. Conclusions Altered OAEs support the hypothesis of cochlear alterations in PD. No evidence was found for the involvement of the medial olivocochlear system. Altogether, OAEs may provide an objective early indicator of auditory alterations in PD and should complement subjective tonal audiometry when assessing and monitoring auditory function in PD.
Keywords
Parkinson’s disease (PD), otoacoustic emissions (OAEs), efferent suppression (ES), COCHLEAR MICROMECHANICAL PROPERTIES, PARKINSONS-DISEASE, OLIVOCOCHLEAR EFFERENTS, HEARING IMPAIRMENT, NONMOTOR SYMPTOMS, INNER-EAR, NEURONS, SYSTEM, SCALE, DISCRIMINATION

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MLA
De Groote, Evelien, et al. “The Effect of Parkinson’s Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions.” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, edited by Daniel M. Rasetshwane, vol. 64, no. 4, 2021, pp. 1354–68, doi:10.1044/2020_jslhr-20-00594.
APA
De Groote, E., Bockstael, A., Botteldooren, D., Santens, P., & De Letter, M. (2021). The effect of Parkinson’s disease on otoacoustic emissions and efferent suppression of transient evoked otoacoustic emissions. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 64(4), 1354–1368. https://doi.org/10.1044/2020_jslhr-20-00594
Chicago author-date
De Groote, Evelien, Annelies Bockstael, Dick Botteldooren, Patrick Santens, and Miet De Letter. 2021. “The Effect of Parkinson’s Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions.” Edited by Daniel M. Rasetshwane. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH 64 (4): 1354–68. https://doi.org/10.1044/2020_jslhr-20-00594.
Chicago author-date (all authors)
De Groote, Evelien, Annelies Bockstael, Dick Botteldooren, Patrick Santens, and Miet De Letter. 2021. “The Effect of Parkinson’s Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions.” Ed by. Daniel M. Rasetshwane. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH 64 (4): 1354–1368. doi:10.1044/2020_jslhr-20-00594.
Vancouver
1.
De Groote E, Bockstael A, Botteldooren D, Santens P, De Letter M. The effect of Parkinson’s disease on otoacoustic emissions and efferent suppression of transient evoked otoacoustic emissions. Rasetshwane DM, editor. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH. 2021;64(4):1354–68.
IEEE
[1]
E. De Groote, A. Bockstael, D. Botteldooren, P. Santens, and M. De Letter, “The effect of Parkinson’s disease on otoacoustic emissions and efferent suppression of transient evoked otoacoustic emissions,” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, vol. 64, no. 4, pp. 1354–1368, 2021.
@article{8701517,
  abstract     = {{Purpose
Several studies have demonstrated increased auditory thresholds in patients with Parkinson's disease (PD) based on subjective tonal audiometry. However, the pathophysiological mechanisms underlying auditory dysfunction in PD remain elusive. The primary aim of this study was to investigate cochlear and olivocochlear function in PD using objective measurements and to assess the effect of dopaminergic medication on auditory function.

Method
Eighteen patients with PD and 18 gender- and age-matched healthy controls (HCs) were included. Patients with PD participated in medication on and off conditions. Linear mixed models were used to determine the effect of PD on tonal audiometry, transient evoked and distortion product otoacoustic emissions (OAEs), and efferent suppression (ES).

Results
Tonal audiometry revealed normal auditory thresholds in patients with PD for their age across all frequencies. OAE signal amplitudes demonstrated a significant interaction effect between group (PD vs. HC) and frequency, indicating decreased OAEs at low frequencies and increased OAEs at high frequencies in patients with PD. No significant differences were found between patients with PD and HCs regarding ES. In addition, no significant effect of medication status was found on auditory measurements in patients with PD.

Conclusions
Altered OAEs support the hypothesis of cochlear alterations in PD. No evidence was found for the involvement of the medial olivocochlear system. Altogether, OAEs may provide an objective early indicator of auditory alterations in PD and should complement subjective tonal audiometry when assessing and monitoring auditory function in PD.}},
  author       = {{De Groote, Evelien and Bockstael, Annelies and Botteldooren, Dick and Santens, Patrick and De Letter, Miet}},
  editor       = {{Rasetshwane, Daniel M.}},
  issn         = {{1092-4388}},
  journal      = {{JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH}},
  keywords     = {{Parkinson’s disease (PD),otoacoustic emissions (OAEs),efferent suppression (ES),COCHLEAR MICROMECHANICAL PROPERTIES,PARKINSONS-DISEASE,OLIVOCOCHLEAR EFFERENTS,HEARING IMPAIRMENT,NONMOTOR SYMPTOMS,INNER-EAR,NEURONS,SYSTEM,SCALE,DISCRIMINATION}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1354--1368}},
  title        = {{The effect of Parkinson's disease on otoacoustic emissions and efferent suppression of transient evoked otoacoustic emissions}},
  url          = {{http://dx.doi.org/10.1044/2020_jslhr-20-00594}},
  volume       = {{64}},
  year         = {{2021}},
}

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