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Microplastics in the human digestive environment : a focus on the potential and challenges facing in vitro gut model development

Elora Fournier, Lucie Etienne-Mesmin, Charlotte Grootaert (UGent) , Lotte Jelsbak, Kristian Syberg, Stéphanie Blanquet-Diot and Muriel Mercier-Bonin
(2021) JOURNAL OF HAZARDOUS MATERIALS. 415.
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Abstract
Plastic pollution is a major issue worldwide, generating massive amounts of smaller plastic particles, including microplastics (MPs). Their ubiquitous nature in the environment but also in foodstuff and consumer packaged goods has revealed potential threats to humans who can be contaminated mainly through air, food and water consumption. In this review, the current literature on human exposure to MPs is summarized with a focus on the gastrointestinal tract as portal of entry. Then, we discuss the vector effect of MPs, in their pristine versus weathered forms, with well-known contaminants as heavy metals and chemicals, or more emerging ones as antibiotics or microbial pathogens, like Pseudomonas spp., Vibrio spp., Campylobacter spp. and Escherichia coli. Comprehensive knowledge on MP fate in the gastrointestinal tract and their potential impact on gut homeostasis disruption, including gut microbiota, mucus and epithelial barrier, is reported in vitro and in vivo in mammals. Special emphasis is given on the crucial need of developing robust in vitro gut models to adequately simulate human digestive physiology and absorption processes. Finally, this review points out future research directions on MPs in human intestinal health.
Keywords
Environmental Engineering, Waste Management and Disposal, Pollution, Health, Toxicology and Mutagenesis, Environmental Chemistry, Microplastics, Vector effect, Digestion, Intestinal barrier, Human in vitro gut models, PLASTIC RESIN PELLETS, GASTROINTESTINAL-TRACT, HUMAN HEALTH, MICROBIOTA, POLYETHYLENE, POLYSTYRENE, CHEMICALS, BACTERIAL, RELEASE, IMPACT

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MLA
Fournier, Elora, et al. “Microplastics in the Human Digestive Environment : A Focus on the Potential and Challenges Facing in Vitro Gut Model Development.” JOURNAL OF HAZARDOUS MATERIALS, vol. 415, 2021, doi:10.1016/j.jhazmat.2021.125632.
APA
Fournier, E., Etienne-Mesmin, L., Grootaert, C., Jelsbak, L., Syberg, K., Blanquet-Diot, S., & Mercier-Bonin, M. (2021). Microplastics in the human digestive environment : a focus on the potential and challenges facing in vitro gut model development. JOURNAL OF HAZARDOUS MATERIALS, 415. https://doi.org/10.1016/j.jhazmat.2021.125632
Chicago author-date
Fournier, Elora, Lucie Etienne-Mesmin, Charlotte Grootaert, Lotte Jelsbak, Kristian Syberg, Stéphanie Blanquet-Diot, and Muriel Mercier-Bonin. 2021. “Microplastics in the Human Digestive Environment : A Focus on the Potential and Challenges Facing in Vitro Gut Model Development.” JOURNAL OF HAZARDOUS MATERIALS 415. https://doi.org/10.1016/j.jhazmat.2021.125632.
Chicago author-date (all authors)
Fournier, Elora, Lucie Etienne-Mesmin, Charlotte Grootaert, Lotte Jelsbak, Kristian Syberg, Stéphanie Blanquet-Diot, and Muriel Mercier-Bonin. 2021. “Microplastics in the Human Digestive Environment : A Focus on the Potential and Challenges Facing in Vitro Gut Model Development.” JOURNAL OF HAZARDOUS MATERIALS 415. doi:10.1016/j.jhazmat.2021.125632.
Vancouver
1.
Fournier E, Etienne-Mesmin L, Grootaert C, Jelsbak L, Syberg K, Blanquet-Diot S, et al. Microplastics in the human digestive environment : a focus on the potential and challenges facing in vitro gut model development. JOURNAL OF HAZARDOUS MATERIALS. 2021;415.
IEEE
[1]
E. Fournier et al., “Microplastics in the human digestive environment : a focus on the potential and challenges facing in vitro gut model development,” JOURNAL OF HAZARDOUS MATERIALS, vol. 415, 2021.
@article{8699447,
  abstract     = {{Plastic pollution is a major issue worldwide, generating massive amounts of smaller plastic particles, including microplastics (MPs). Their ubiquitous nature in the environment but also in foodstuff and consumer packaged goods has revealed potential threats to humans who can be contaminated mainly through air, food and water consumption. In this review, the current literature on human exposure to MPs is summarized with a focus on the gastrointestinal tract as portal of entry. Then, we discuss the vector effect of MPs, in their pristine versus weathered forms, with well-known contaminants as heavy metals and chemicals, or more emerging ones as antibiotics or microbial pathogens, like Pseudomonas spp., Vibrio spp., Campylobacter spp. and Escherichia coli. Comprehensive knowledge on MP fate in the gastrointestinal tract and their potential impact on gut homeostasis disruption, including gut microbiota, mucus and epithelial barrier, is reported in vitro and in vivo in mammals. Special emphasis is given on the crucial need of developing robust in vitro gut models to adequately simulate human digestive physiology and absorption processes. Finally, this review points out future research directions on MPs in human intestinal health.}},
  articleno    = {{125632}},
  author       = {{Fournier, Elora and Etienne-Mesmin, Lucie and Grootaert, Charlotte and Jelsbak, Lotte and Syberg, Kristian and Blanquet-Diot, Stéphanie and Mercier-Bonin, Muriel}},
  issn         = {{0304-3894}},
  journal      = {{JOURNAL OF HAZARDOUS MATERIALS}},
  keywords     = {{Environmental Engineering,Waste Management and Disposal,Pollution,Health,Toxicology and Mutagenesis,Environmental Chemistry,Microplastics,Vector effect,Digestion,Intestinal barrier,Human in vitro gut models,PLASTIC RESIN PELLETS,GASTROINTESTINAL-TRACT,HUMAN HEALTH,MICROBIOTA,POLYETHYLENE,POLYSTYRENE,CHEMICALS,BACTERIAL,RELEASE,IMPACT}},
  language     = {{eng}},
  pages        = {{15}},
  title        = {{Microplastics in the human digestive environment : a focus on the potential and challenges facing in vitro gut model development}},
  url          = {{http://doi.org/10.1016/j.jhazmat.2021.125632}},
  volume       = {{415}},
  year         = {{2021}},
}
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