@article{8699263,
  abstract     = {{Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1% (3.3-4.8), 3.9% (2.6-5.1) and 3.6% (2.0-5.2), respectively). Surgery performed >= 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5% (0.9-2.1%)). After a >= 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0%), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms >= 7 weeks from diagnosis may benefit from further delay.}},
  author       = {{Nepogodiev, D. and Dhondt, Bert and BONTINCK, JULIE and Van Daele, Elke and Vandeputte, Mathieu and Lekuya Monka, Hervé and Collaborative, GlobalSurg and Collaborative, COVIDSurg}},
  issn         = {{0003-2409}},
  journal      = {{ANAESTHESIA}},
  keywords     = {{Anesthesiology and Pain Medicine,COVID-19,delay,SARS-CoV-2,surgery,timing,PULMONARY COMPLICATIONS,MULTICENTER}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{748--758}},
  title        = {{Timing of surgery following SARS‐CoV‐2 infection : an international prospective cohort study}},
  url          = {{http://doi.org/10.1111/anae.15458}},
  volume       = {{76}},
  year         = {{2021}},
}

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