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Antimicrobial susceptibility pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates

Rita Matos, Chloë De Witte (UGent) , Annemieke Smet (UGent) , Helena Berlamont, Sofie De Bruyckere (UGent) , Irina Amorim, Fatima Gartner and Freddy Haesebrouck (UGent)
(2020) MICROORGANISMS. 8(6).
Author
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Abstract
A combined agar and broth dilution method followed by qPCR was used to determine the antimicrobial susceptibility of felineH. heilmanniiandH. ailurogastricusisolates. AllH. ailurogastricusisolates showed a monomodal distribution of MICs for all the antimicrobial agents tested. ForH. heilmannii, a bimodal distribution was observed for azithromycin, enrofloxacin, spectinomycin, and lincomycin. Single nucleotide polymorphisms (SNPs) were found in 50S ribosomal proteins L2 and L3 of theH. heilmanniiisolate not belonging to the WT population for azithromycin, and in 30S ribosomal proteins S1, S7, and S12 of the isolate not belonging to the WT population for spectinomycin. The antimicrobial resistance mechanism to enrofloxacin and lincomycin remains unknown (2 and 1H. heilmanniiisolate(s), resp.). Furthermore,H. heilmanniiisolates showed higher MICs for neomycin compared toH. ailurogastricusisolates which may be related to the presence of SNPs in several 30S and 50S ribosomal protein encoding genes and ribosomal RNA methyltransferase genes. This study shows that acquired resistance to azithromycin, spectinomycin, enrofloxacin, and lincomycin occasionally occurs in felineH. heilmanniiisolates. As pets may constitute a source of infection for humans, this should be kept in mind when dealing with a human patient infected withH. heilmannii.
Keywords
23S RIBOSOMAL-RNA, HELICOBACTER-HEILMANNII, IN-VITRO, STREPTOMYCIN, RESISTANCE, MUTATIONS, PYLORI, RPSL, BIZZOZERONII, CHILDREN, TIAMULIN, Helicobacter heilmannii, Helicobacter ailurogastricus, antimicrobial, susceptibility, zoonoses, gastric disease, resistance mechanisms

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Citation

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MLA
Matos, Rita, et al. “Antimicrobial Susceptibility Pattern of Helicobacter Heilmannii and Helicobacter Ailurogastricus Isolates.” MICROORGANISMS, vol. 8, no. 6, 2020, doi:10.3390/microorganisms8060957.
APA
Matos, R., De Witte, C., Smet, A., Berlamont, H., De Bruyckere, S., Amorim, I., … Haesebrouck, F. (2020). Antimicrobial susceptibility pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates. MICROORGANISMS, 8(6). https://doi.org/10.3390/microorganisms8060957
Chicago author-date
Matos, Rita, Chloë De Witte, Annemieke Smet, Helena Berlamont, Sofie De Bruyckere, Irina Amorim, Fatima Gartner, and Freddy Haesebrouck. 2020. “Antimicrobial Susceptibility Pattern of Helicobacter Heilmannii and Helicobacter Ailurogastricus Isolates.” MICROORGANISMS 8 (6). https://doi.org/10.3390/microorganisms8060957.
Chicago author-date (all authors)
Matos, Rita, Chloë De Witte, Annemieke Smet, Helena Berlamont, Sofie De Bruyckere, Irina Amorim, Fatima Gartner, and Freddy Haesebrouck. 2020. “Antimicrobial Susceptibility Pattern of Helicobacter Heilmannii and Helicobacter Ailurogastricus Isolates.” MICROORGANISMS 8 (6). doi:10.3390/microorganisms8060957.
Vancouver
1.
Matos R, De Witte C, Smet A, Berlamont H, De Bruyckere S, Amorim I, et al. Antimicrobial susceptibility pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates. MICROORGANISMS. 2020;8(6).
IEEE
[1]
R. Matos et al., “Antimicrobial susceptibility pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates,” MICROORGANISMS, vol. 8, no. 6, 2020.
@article{8697900,
  abstract     = {{A combined agar and broth dilution method followed by qPCR was used to determine the antimicrobial susceptibility of felineH. heilmanniiandH. ailurogastricusisolates. AllH. ailurogastricusisolates showed a monomodal distribution of MICs for all the antimicrobial agents tested. ForH. heilmannii, a bimodal distribution was observed for azithromycin, enrofloxacin, spectinomycin, and lincomycin. Single nucleotide polymorphisms (SNPs) were found in 50S ribosomal proteins L2 and L3 of theH. heilmanniiisolate not belonging to the WT population for azithromycin, and in 30S ribosomal proteins S1, S7, and S12 of the isolate not belonging to the WT population for spectinomycin. The antimicrobial resistance mechanism to enrofloxacin and lincomycin remains unknown (2 and 1H. heilmanniiisolate(s), resp.). Furthermore,H. heilmanniiisolates showed higher MICs for neomycin compared toH. ailurogastricusisolates which may be related to the presence of SNPs in several 30S and 50S ribosomal protein encoding genes and ribosomal RNA methyltransferase genes. This study shows that acquired resistance to azithromycin, spectinomycin, enrofloxacin, and lincomycin occasionally occurs in felineH. heilmanniiisolates. As pets may constitute a source of infection for humans, this should be kept in mind when dealing with a human patient infected withH. heilmannii.}},
  articleno    = {{957}},
  author       = {{Matos, Rita and De Witte, Chloë and Smet, Annemieke and Berlamont, Helena and De Bruyckere, Sofie and Amorim, Irina and Gartner, Fatima and Haesebrouck, Freddy}},
  issn         = {{2076-2607}},
  journal      = {{MICROORGANISMS}},
  keywords     = {{23S RIBOSOMAL-RNA,HELICOBACTER-HEILMANNII,IN-VITRO,STREPTOMYCIN,RESISTANCE,MUTATIONS,PYLORI,RPSL,BIZZOZERONII,CHILDREN,TIAMULIN,Helicobacter heilmannii,Helicobacter ailurogastricus,antimicrobial,susceptibility,zoonoses,gastric disease,resistance mechanisms}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{16}},
  title        = {{Antimicrobial susceptibility pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates}},
  url          = {{http://doi.org/10.3390/microorganisms8060957}},
  volume       = {{8}},
  year         = {{2020}},
}
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