Turning a pathogen protein into a therapeutic tool for sepsis
- Author
- Tineke Vanderhaeghen (UGent) , Charlotte Wallaeys (UGent) and Claude Libert (UGent)
- Organization
- Abstract
- Sepsis causes unacceptably high amounts of deaths worldwide. It is a huge unmet medical need, and new therapeutic interventions for sepsis and septic shock are urgently needed. By studying the mechanism by which a bacterial protein undermines the inflammatory function of macrophages, Kim et al, in the last issue of EMBO Molecular Medicine, have developed a new therapeutic protein drug, which appears to have very promising protective activities in a well-validated and aggressive polymicrobial sepsis model in mice. The chimeric protein is thought to limit macrophage inflammation while activating phagocytosis, and so, it hits two macrophage pathways at once.
Downloads
-
published.pdf
- full text (Published version)
- |
- open access
- |
- |
- 400.73 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8697697
- MLA
- Vanderhaeghen, Tineke, et al. “Turning a Pathogen Protein into a Therapeutic Tool for Sepsis.” EMBO MOLECULAR MEDICINE, vol. 13, no. 1, 2021, doi:10.15252/emmm.202013589.
- APA
- Vanderhaeghen, T., Wallaeys, C., & Libert, C. (2021). Turning a pathogen protein into a therapeutic tool for sepsis. https://doi.org/10.15252/emmm.202013589
- Chicago author-date
- Vanderhaeghen, Tineke, Charlotte Wallaeys, and Claude Libert. 2021. “Turning a Pathogen Protein into a Therapeutic Tool for Sepsis.” EMBO MOLECULAR MEDICINE. https://doi.org/10.15252/emmm.202013589.
- Chicago author-date (all authors)
- Vanderhaeghen, Tineke, Charlotte Wallaeys, and Claude Libert. 2021. “Turning a Pathogen Protein into a Therapeutic Tool for Sepsis.” EMBO MOLECULAR MEDICINE. doi:10.15252/emmm.202013589.
- Vancouver
- 1.Vanderhaeghen T, Wallaeys C, Libert C. Turning a pathogen protein into a therapeutic tool for sepsis. Vol. 13, EMBO MOLECULAR MEDICINE. 2021.
- IEEE
- [1]T. Vanderhaeghen, C. Wallaeys, and C. Libert, “Turning a pathogen protein into a therapeutic tool for sepsis,” EMBO MOLECULAR MEDICINE, vol. 13, no. 1. 2021.
@misc{8697697, abstract = {{Sepsis causes unacceptably high amounts of deaths worldwide. It is a huge unmet medical need, and new therapeutic interventions for sepsis and septic shock are urgently needed. By studying the mechanism by which a bacterial protein undermines the inflammatory function of macrophages, Kim et al, in the last issue of EMBO Molecular Medicine, have developed a new therapeutic protein drug, which appears to have very promising protective activities in a well-validated and aggressive polymicrobial sepsis model in mice. The chimeric protein is thought to limit macrophage inflammation while activating phagocytosis, and so, it hits two macrophage pathways at once.}}, articleno = {{e13589}}, author = {{Vanderhaeghen, Tineke and Wallaeys, Charlotte and Libert, Claude}}, issn = {{1757-4676}}, language = {{eng}}, number = {{1}}, pages = {{3}}, series = {{EMBO MOLECULAR MEDICINE}}, title = {{Turning a pathogen protein into a therapeutic tool for sepsis}}, url = {{http://doi.org/10.15252/emmm.202013589}}, volume = {{13}}, year = {{2021}}, }
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: