Lin28b controls a neonatal to adult switch in B cell positive selection
- Author
- Stijn Vanhee (UGent) , Hugo Åkerstrand, Trine Ahn Kristiansen, Sebak Datta, Giorgia Montano, Stefano Vergani, Stefan Lang, Jonas Ungerbäck, Alexander Doyle, Karin Olsson, Giulia Beneventi, Christina T. Jensen, Cristian Bellodi, Shamit Soneji, Mikael Sigvardsson, Elin Jaensson Gyllenbäck and Joan Yuan
- Organization
- Abstract
- <jats:p>The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice. We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5<jats:sup>+</jats:sup>immature B cells in particular. Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19<jats:sup>−/−</jats:sup>adult mice. Thus, the temporally restricted expression of<jats:italic>Lin28b</jats:italic>relaxes the rules for B cell selection during ontogeny by modulating tonic signaling. We propose that this neonatal mode of B cell selection represents a cell-intrinsic cue to accelerate the de novo establishment of the adaptive immune system and incorporate a layer of natural antibody-mediated immunity throughout life.</jats:p>
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8697505
- MLA
- Vanhee, Stijn, et al. “Lin28b Controls a Neonatal to Adult Switch in B Cell Positive Selection.” Science Immunology, vol. 4, no. 39, 2019, doi:10.1126/sciimmunol.aax4453.
- APA
- Vanhee, S., Åkerstrand, H., Kristiansen, T. A., Datta, S., Montano, G., Vergani, S., … Yuan, J. (2019). Lin28b controls a neonatal to adult switch in B cell positive selection. Science Immunology, 4(39). https://doi.org/10.1126/sciimmunol.aax4453
- Chicago author-date
- Vanhee, Stijn, Hugo Åkerstrand, Trine Ahn Kristiansen, Sebak Datta, Giorgia Montano, Stefano Vergani, Stefan Lang, et al. 2019. “Lin28b Controls a Neonatal to Adult Switch in B Cell Positive Selection.” Science Immunology 4 (39). https://doi.org/10.1126/sciimmunol.aax4453.
- Chicago author-date (all authors)
- Vanhee, Stijn, Hugo Åkerstrand, Trine Ahn Kristiansen, Sebak Datta, Giorgia Montano, Stefano Vergani, Stefan Lang, Jonas Ungerbäck, Alexander Doyle, Karin Olsson, Giulia Beneventi, Christina T. Jensen, Cristian Bellodi, Shamit Soneji, Mikael Sigvardsson, Elin Jaensson Gyllenbäck, and Joan Yuan. 2019. “Lin28b Controls a Neonatal to Adult Switch in B Cell Positive Selection.” Science Immunology 4 (39). doi:10.1126/sciimmunol.aax4453.
- Vancouver
- 1.Vanhee S, Åkerstrand H, Kristiansen TA, Datta S, Montano G, Vergani S, et al. Lin28b controls a neonatal to adult switch in B cell positive selection. Science Immunology. 2019;4(39).
- IEEE
- [1]S. Vanhee et al., “Lin28b controls a neonatal to adult switch in B cell positive selection,” Science Immunology, vol. 4, no. 39, 2019.
@article{8697505,
abstract = {{<jats:p>The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice. We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5<jats:sup>+</jats:sup>immature B cells in particular. Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19<jats:sup>−/−</jats:sup>adult mice. Thus, the temporally restricted expression of<jats:italic>Lin28b</jats:italic>relaxes the rules for B cell selection during ontogeny by modulating tonic signaling. We propose that this neonatal mode of B cell selection represents a cell-intrinsic cue to accelerate the de novo establishment of the adaptive immune system and incorporate a layer of natural antibody-mediated immunity throughout life.</jats:p>}},
articleno = {{eaax4453}},
author = {{Vanhee, Stijn and Åkerstrand, Hugo and Kristiansen, Trine Ahn and Datta, Sebak and Montano, Giorgia and Vergani, Stefano and Lang, Stefan and Ungerbäck, Jonas and Doyle, Alexander and Olsson, Karin and Beneventi, Giulia and Jensen, Christina T. and Bellodi, Cristian and Soneji, Shamit and Sigvardsson, Mikael and Gyllenbäck, Elin Jaensson and Yuan, Joan}},
issn = {{2470-9468}},
journal = {{Science Immunology}},
language = {{eng}},
number = {{39}},
title = {{Lin28b controls a neonatal to adult switch in B cell positive selection}},
url = {{http://doi.org/10.1126/sciimmunol.aax4453}},
volume = {{4}},
year = {{2019}},
}
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