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Prospects of germline nuclear transfer in women with diminished ovarian reserve

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Abstract
Diminished ovarian reserve (DOR) is associated with a reduced quantity and quality of the retrieved oocytes, usually leading to poor reproductive outcomes which remain a great challenge for assisted reproduction technology (ART). Women with DOR often have to seek for oocyte donation, precluding genetically related offspring. Germline nuclear transfer (NT) is a novel technology in ART that involves the transfer of the nuclear genome from an affected oocyte/zygote of the patient to the cytoplast of an enucleated donor oocyte/zygote. Therefore, it offers opportunities for the generation of genetically related embryos. Currently, although NT is clinically applied only in women with serious mitochondrial DNA disorders, this technology has also been proposed to overcome certain forms of female infertility, such as advanced maternal age and embryo developmental arrest. In this review, we are proposing the NT technology as a future treatment option for DOR patients. Strikingly, the application of different NT strategies will result in an increase of the total number of available reconstituted embryos for DOR patients.
Keywords
diminished ovarian reserve, poor ovarian response, oocyte quality, germline nuclear transfer, spindle transfer, polar body transfer

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MLA
Christodoulaki, Antonia, et al. “Prospects of Germline Nuclear Transfer in Women with Diminished Ovarian Reserve.” FRONTIERS IN ENDOCRINOLOGY, vol. 12, 2021, doi:10.3389/fendo.2021.635370.
APA
Christodoulaki, A., Boel, A., Tang, M., De Roo, C., Stoop, D., & Heindryckx, B. (2021). Prospects of germline nuclear transfer in women with diminished ovarian reserve. FRONTIERS IN ENDOCRINOLOGY, 12. https://doi.org/10.3389/fendo.2021.635370
Chicago author-date
Christodoulaki, Antonia, Annekatrien Boel, Maoxing Tang, Chloë De Roo, Dominic Stoop, and Björn Heindryckx. 2021. “Prospects of Germline Nuclear Transfer in Women with Diminished Ovarian Reserve.” FRONTIERS IN ENDOCRINOLOGY 12. https://doi.org/10.3389/fendo.2021.635370.
Chicago author-date (all authors)
Christodoulaki, Antonia, Annekatrien Boel, Maoxing Tang, Chloë De Roo, Dominic Stoop, and Björn Heindryckx. 2021. “Prospects of Germline Nuclear Transfer in Women with Diminished Ovarian Reserve.” FRONTIERS IN ENDOCRINOLOGY 12. doi:10.3389/fendo.2021.635370.
Vancouver
1.
Christodoulaki A, Boel A, Tang M, De Roo C, Stoop D, Heindryckx B. Prospects of germline nuclear transfer in women with diminished ovarian reserve. FRONTIERS IN ENDOCRINOLOGY. 2021;12.
IEEE
[1]
A. Christodoulaki, A. Boel, M. Tang, C. De Roo, D. Stoop, and B. Heindryckx, “Prospects of germline nuclear transfer in women with diminished ovarian reserve,” FRONTIERS IN ENDOCRINOLOGY, vol. 12, 2021.
@article{8697300,
  abstract     = {{Diminished ovarian reserve (DOR) is associated with a reduced quantity and quality of the retrieved oocytes, usually leading to poor reproductive outcomes which remain a great challenge for assisted reproduction technology (ART). Women with DOR often have to seek for oocyte donation, precluding genetically related offspring. Germline nuclear transfer (NT) is a novel technology in ART that involves the transfer of the nuclear genome from an affected oocyte/zygote of the patient to the cytoplast of an enucleated donor oocyte/zygote. Therefore, it offers opportunities for the generation of genetically related embryos. Currently, although NT is clinically applied only in women with serious mitochondrial DNA disorders, this technology has also been proposed to overcome certain forms of female infertility, such as advanced maternal age and embryo developmental arrest. In this review, we are proposing the NT technology as a future treatment option for DOR patients. Strikingly, the application of different NT strategies will result in an increase of the total number of available reconstituted embryos for DOR patients.}},
  articleno    = {{635370}},
  author       = {{Christodoulaki, Antonia and Boel, Annekatrien and Tang, Maoxing and De Roo, Chloë and Stoop, Dominic and Heindryckx, Björn}},
  issn         = {{1664-2392}},
  journal      = {{FRONTIERS IN ENDOCRINOLOGY}},
  keywords     = {{diminished ovarian reserve,poor ovarian response,oocyte quality,germline nuclear transfer,spindle transfer,polar body transfer}},
  language     = {{eng}},
  pages        = {{13}},
  title        = {{Prospects of germline nuclear transfer in women with diminished ovarian reserve}},
  url          = {{http://dx.doi.org/10.3389/fendo.2021.635370}},
  volume       = {{12}},
  year         = {{2021}},
}

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