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Cognitive behavioral based group psychotherapy focusing on repetitive negative thinking : decreased uncontrollability of rumination is related to brain perfusion increases in the left dorsolateral prefrontal cortex

Chris Baeken (UGent) , Guo-Rong Wu, Roland Rogiers (UGent) , Jonathan Remue (UGent) , Gilbert Lemmens (UGent) and Rudi De Raedt (UGent)
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Abstract
Repetitive negative thinking (RNT) is a core process underlying various psychiatric disorders. ?Uncontrollability of rumination (UOR)? is one the most maladaptive factors of rumination, but little is known on how cognitive behavioral focused RNT psychotherapy may alter brain activity. In a subsample of 47 patients suffering from RNT who also underwent brain imaging (registered RCT trial NCT01983033), we evaluated the effect of cognitive behavioral based group psychotherapy (CBGP) (n = 25) as compared to a delayed treatment control group (DTCG) (n = 22) on frontolimbic brain perfusion with a focus on UOR. This RNT construct was measured using the subscale ?uncontrollability? of the Dutch version of the Rumination on Sadness Scale (LARSS-U). Brain perfusion was assessed with arterial spin labeling (ASL)-fMRI. LARSS-U scale scores significantly decreased in the CBGP cohort whereas no significant changes emerged in the DTCG group. Compared to the DTCG, this decrease on UOR in the CBGP group was related to significant perfusion increases in the left (dorsolateral) prefrontal cortex, part of the executive network. Besides the fact that CBGP significantly reduced RNT, this attenuation of uncontrollable ruminative thoughts was related to brain perfusion increases areas documented to be involved in the top down control of adaptive emotion regulation and the inhibition of ruminative processes.
Keywords
Biological Psychiatry, Psychiatry and Mental health, ASL, Repetitive negative thinking, Group psychotherapy, LARSS Uncontrollability

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MLA
Baeken, Chris, et al. “Cognitive Behavioral Based Group Psychotherapy Focusing on Repetitive Negative Thinking : Decreased Uncontrollability of Rumination Is Related to Brain Perfusion Increases in the Left Dorsolateral Prefrontal Cortex.” JOURNAL OF PSYCHIATRIC RESEARCH, vol. 136, 2021, pp. 281–87, doi:10.1016/j.jpsychires.2021.02.011.
APA
Baeken, C., Wu, G.-R., Rogiers, R., Remue, J., Lemmens, G., & De Raedt, R. (2021). Cognitive behavioral based group psychotherapy focusing on repetitive negative thinking : decreased uncontrollability of rumination is related to brain perfusion increases in the left dorsolateral prefrontal cortex. JOURNAL OF PSYCHIATRIC RESEARCH, 136, 281–287. https://doi.org/10.1016/j.jpsychires.2021.02.011
Chicago author-date
Baeken, Chris, Guo-Rong Wu, Roland Rogiers, Jonathan Remue, Gilbert Lemmens, and Rudi De Raedt. 2021. “Cognitive Behavioral Based Group Psychotherapy Focusing on Repetitive Negative Thinking : Decreased Uncontrollability of Rumination Is Related to Brain Perfusion Increases in the Left Dorsolateral Prefrontal Cortex.” JOURNAL OF PSYCHIATRIC RESEARCH 136: 281–87. https://doi.org/10.1016/j.jpsychires.2021.02.011.
Chicago author-date (all authors)
Baeken, Chris, Guo-Rong Wu, Roland Rogiers, Jonathan Remue, Gilbert Lemmens, and Rudi De Raedt. 2021. “Cognitive Behavioral Based Group Psychotherapy Focusing on Repetitive Negative Thinking : Decreased Uncontrollability of Rumination Is Related to Brain Perfusion Increases in the Left Dorsolateral Prefrontal Cortex.” JOURNAL OF PSYCHIATRIC RESEARCH 136: 281–287. doi:10.1016/j.jpsychires.2021.02.011.
Vancouver
1.
Baeken C, Wu G-R, Rogiers R, Remue J, Lemmens G, De Raedt R. Cognitive behavioral based group psychotherapy focusing on repetitive negative thinking : decreased uncontrollability of rumination is related to brain perfusion increases in the left dorsolateral prefrontal cortex. JOURNAL OF PSYCHIATRIC RESEARCH. 2021;136:281–7.
IEEE
[1]
C. Baeken, G.-R. Wu, R. Rogiers, J. Remue, G. Lemmens, and R. De Raedt, “Cognitive behavioral based group psychotherapy focusing on repetitive negative thinking : decreased uncontrollability of rumination is related to brain perfusion increases in the left dorsolateral prefrontal cortex,” JOURNAL OF PSYCHIATRIC RESEARCH, vol. 136, pp. 281–287, 2021.
@article{8696582,
  abstract     = {{Repetitive negative thinking (RNT) is a core process underlying various psychiatric disorders. ?Uncontrollability of rumination (UOR)? is one the most maladaptive factors of rumination, but little is known on how cognitive behavioral focused RNT psychotherapy may alter brain activity. In a subsample of 47 patients suffering from RNT who also underwent brain imaging (registered RCT trial NCT01983033), we evaluated the effect of cognitive behavioral based group psychotherapy (CBGP) (n = 25) as compared to a delayed treatment control group (DTCG) (n = 22) on frontolimbic brain perfusion with a focus on UOR. This RNT construct was measured using the subscale ?uncontrollability? of the Dutch version of the Rumination on Sadness Scale (LARSS-U). Brain perfusion was assessed with arterial spin labeling (ASL)-fMRI. LARSS-U scale scores significantly decreased in the CBGP cohort whereas no significant changes emerged in the DTCG group. Compared to the DTCG, this decrease on UOR in the CBGP group was related to significant perfusion increases in the left (dorsolateral) prefrontal cortex, part of the executive network. Besides the fact that CBGP significantly reduced RNT, this attenuation of uncontrollable ruminative thoughts was related to brain perfusion increases areas documented to be involved in the top down control of adaptive emotion regulation and the inhibition of ruminative processes.}},
  author       = {{Baeken, Chris and Wu, Guo-Rong and Rogiers, Roland and Remue, Jonathan and Lemmens, Gilbert and De Raedt, Rudi}},
  issn         = {{0022-3956}},
  journal      = {{JOURNAL OF PSYCHIATRIC RESEARCH}},
  keywords     = {{Biological Psychiatry,Psychiatry and Mental health,ASL,Repetitive negative thinking,Group psychotherapy,LARSS Uncontrollability}},
  language     = {{eng}},
  pages        = {{281--287}},
  title        = {{Cognitive behavioral based group psychotherapy focusing on repetitive negative thinking : decreased uncontrollability of rumination is related to brain perfusion increases in the left dorsolateral prefrontal cortex}},
  url          = {{http://doi.org/10.1016/j.jpsychires.2021.02.011}},
  volume       = {{136}},
  year         = {{2021}},
}

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