Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans
- Author
- Thibaux Van der Stede (UGent) , Laura Blancquaert, Flore Stassen, Ruud Van Thienen (UGent) , Inge Everaert (UGent) , Chris Vervaet (UGent) , Lasse Gliemann, Ylva Hellsten and Wim Derave (UGent)
- Organization
- Abstract
- Exercise training is a powerful strategy to prevent and combat cardiovascular and metabolic diseases, although the integrative nature of the training-induced adaptations is not completely understood. We show that chronic blockade of histamine H-1/H-2 receptors led to marked impairments of microvascular and mitochondrial adaptations to interval training in humans. Consequently, functional adaptations in exercise capacity, whole-body glycemic control, and vascular function were blunted. Furthermore, the sustained elevation of muscle perfusion after acute interval exercise was severely reduced when H-1/H-2 receptors were pharmaceutically blocked. Our work suggests that histamine H-1/H-2 receptors are important transducers of the integrative exercise training response in humans, potentially related to regulation of optimal post-exercise muscle perfusion. These findings add to our understanding of how skeletal muscle and the cardiovascular system adapt to exercise training, knowledge that will help us further unravel and develop the exercise-is-medicine concept.
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8695985
- MLA
- Van der Stede, Thibaux, et al. “Histamine H1 and H2 Receptors Are Essential Transducers of the Integrative Exercise Training Response in Humans.” SCIENCE ADVANCES, vol. 7, no. 16, 2021, doi:10.1126/sciadv.abf2856.
- APA
- Van der Stede, T., Blancquaert, L., Stassen, F., Van Thienen, R., Everaert, I., Vervaet, C., … Derave, W. (2021). Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. SCIENCE ADVANCES, 7(16). https://doi.org/10.1126/sciadv.abf2856
- Chicago author-date
- Van der Stede, Thibaux, Laura Blancquaert, Flore Stassen, Ruud Van Thienen, Inge Everaert, Chris Vervaet, Lasse Gliemann, Ylva Hellsten, and Wim Derave. 2021. “Histamine H1 and H2 Receptors Are Essential Transducers of the Integrative Exercise Training Response in Humans.” SCIENCE ADVANCES 7 (16). https://doi.org/10.1126/sciadv.abf2856.
- Chicago author-date (all authors)
- Van der Stede, Thibaux, Laura Blancquaert, Flore Stassen, Ruud Van Thienen, Inge Everaert, Chris Vervaet, Lasse Gliemann, Ylva Hellsten, and Wim Derave. 2021. “Histamine H1 and H2 Receptors Are Essential Transducers of the Integrative Exercise Training Response in Humans.” SCIENCE ADVANCES 7 (16). doi:10.1126/sciadv.abf2856.
- Vancouver
- 1.Van der Stede T, Blancquaert L, Stassen F, Van Thienen R, Everaert I, Vervaet C, et al. Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. SCIENCE ADVANCES. 2021;7(16).
- IEEE
- [1]T. Van der Stede et al., “Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans,” SCIENCE ADVANCES, vol. 7, no. 16, 2021.
@article{8695985,
abstract = {{Exercise training is a powerful strategy to prevent and combat cardiovascular and metabolic diseases, although the integrative nature of the training-induced adaptations is not completely understood. We show that chronic blockade of histamine H-1/H-2 receptors led to marked impairments of microvascular and mitochondrial adaptations to interval training in humans. Consequently, functional adaptations in exercise capacity, whole-body glycemic control, and vascular function were blunted. Furthermore, the sustained elevation of muscle perfusion after acute interval exercise was severely reduced when H-1/H-2 receptors were pharmaceutically blocked. Our work suggests that histamine H-1/H-2 receptors are important transducers of the integrative exercise training response in humans, potentially related to regulation of optimal post-exercise muscle perfusion. These findings add to our understanding of how skeletal muscle and the cardiovascular system adapt to exercise training, knowledge that will help us further unravel and develop the exercise-is-medicine concept.}},
articleno = {{eabf2856}},
author = {{Van der Stede, Thibaux and Blancquaert, Laura and Stassen, Flore and Van Thienen, Ruud and Everaert, Inge and Vervaet, Chris and Gliemann, Lasse and Hellsten, Ylva and Derave, Wim}},
issn = {{2375-2548}},
journal = {{SCIENCE ADVANCES}},
language = {{eng}},
number = {{16}},
pages = {{12}},
title = {{Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans}},
url = {{http://dx.doi.org/10.1126/sciadv.abf2856}},
volume = {{7}},
year = {{2021}},
}
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