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Does tissue imprinting restrict macrophage plasticity?

Martin Guilliams (UGent) and Freya Svedberg (UGent)
(2021) NATURE IMMUNOLOGY. 22(2). p.118-127
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Abstract
Macrophages have long been considered as particularly plastic cells. However, recent work combining fate mapping, single-cell transcriptomics and epigenetics has undermined the macrophage plasticity dogma. Here, we discuss recent studies that have carefully dissected the response of individual macrophage subsets to pulmonary insults and call for an adjustment of the macrophage plasticity concept. We hypothesize that prolonged tissue residency shuts down much of the plasticity of macrophages and propose that the restricted plasticity of resident macrophages has been favored by evolution to safeguard tissue homeostasis. Recruited monocytes are more plastic and their differentiation into resident macrophages during inflammation can result in a dual imprinting from both the ongoing inflammation and the macrophage niche. This results in inflammation-imprinted resident macrophages, and we speculate that rewired niche circuits could maintain this inflammatory state. We believe that this revisited plasticity model offers opportunities to reset the macrophage pool after a severe inflammatory episode.
Keywords
SURFACTANT PROTEIN-A, RESIDENT ALVEOLAR MACROPHAGES, FETAL MONOCYTES, CELLULAR-RESPONSE, DENDRITIC CELLS, I INTERFERON, LUNG, INFECTION, HEMATOPOIESIS, INFLAMMATION

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Citation

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MLA
Guilliams, Martin, and Freya Svedberg. “Does Tissue Imprinting Restrict Macrophage Plasticity?” NATURE IMMUNOLOGY, vol. 22, no. 2, 2021, pp. 118–27, doi:10.1038/s41590-020-00849-2.
APA
Guilliams, M., & Svedberg, F. (2021). Does tissue imprinting restrict macrophage plasticity? NATURE IMMUNOLOGY, 22(2), 118–127. https://doi.org/10.1038/s41590-020-00849-2
Chicago author-date
Guilliams, Martin, and Freya Svedberg. 2021. “Does Tissue Imprinting Restrict Macrophage Plasticity?” NATURE IMMUNOLOGY 22 (2): 118–27. https://doi.org/10.1038/s41590-020-00849-2.
Chicago author-date (all authors)
Guilliams, Martin, and Freya Svedberg. 2021. “Does Tissue Imprinting Restrict Macrophage Plasticity?” NATURE IMMUNOLOGY 22 (2): 118–127. doi:10.1038/s41590-020-00849-2.
Vancouver
1.
Guilliams M, Svedberg F. Does tissue imprinting restrict macrophage plasticity? NATURE IMMUNOLOGY. 2021;22(2):118–27.
IEEE
[1]
M. Guilliams and F. Svedberg, “Does tissue imprinting restrict macrophage plasticity?,” NATURE IMMUNOLOGY, vol. 22, no. 2, pp. 118–127, 2021.
@article{8695026,
  abstract     = {{Macrophages have long been considered as particularly plastic cells. However, recent work combining fate mapping, single-cell transcriptomics and epigenetics has undermined the macrophage plasticity dogma. Here, we discuss recent studies that have carefully dissected the response of individual macrophage subsets to pulmonary insults and call for an adjustment of the macrophage plasticity concept. We hypothesize that prolonged tissue residency shuts down much of the plasticity of macrophages and propose that the restricted plasticity of resident macrophages has been favored by evolution to safeguard tissue homeostasis. Recruited monocytes are more plastic and their differentiation into resident macrophages during inflammation can result in a dual imprinting from both the ongoing inflammation and the macrophage niche. This results in inflammation-imprinted resident macrophages, and we speculate that rewired niche circuits could maintain this inflammatory state. We believe that this revisited plasticity model offers opportunities to reset the macrophage pool after a severe inflammatory episode.}},
  author       = {{Guilliams, Martin and Svedberg, Freya}},
  issn         = {{1529-2908}},
  journal      = {{NATURE IMMUNOLOGY}},
  keywords     = {{SURFACTANT PROTEIN-A,RESIDENT ALVEOLAR MACROPHAGES,FETAL MONOCYTES,CELLULAR-RESPONSE,DENDRITIC CELLS,I INTERFERON,LUNG,INFECTION,HEMATOPOIESIS,INFLAMMATION}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{118--127}},
  title        = {{Does tissue imprinting restrict macrophage plasticity?}},
  url          = {{http://dx.doi.org/10.1038/s41590-020-00849-2}},
  volume       = {{22}},
  year         = {{2021}},
}
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