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Immune responses and therapeutic options in psoriasis

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Abstract
Psoriasis is a chronic inflammatory disease of the skin that affects about 2-3% of the population and greatly impairs the quality of life of affected individuals. Psoriatic skin is characterized by excessive proliferation and aberrant differentiation of keratinocytes, as well as redness caused by increased dilation of the dermal blood vessels and infiltration of immune cells. Although the pathogenesis of psoriasis has not yet been completely elucidated, it is generally believed to arise from a complex interplay between hyperproliferating keratinocytes and infiltrating, activated immune cells. So far, the exact triggers that elicit this disease are still enigmatic, yet, it is clear that genetic predisposition significantly contributes to the development of psoriasis. In this review, we summarize current knowledge of important cellular and molecular mechanisms driving the initiation and amplification stages of psoriasis development, with a particular focus on cytokines and emerging evidence illustrating keratinocyte-intrinsic defects as key drivers of inflammation. We also discuss mouse models that have contributed to a better understanding of psoriasis pathogenesis and the preclinical development of novel therapeutics, including monoclonal antibodies against specific cytokines or cytokine receptors that have revolutionized the treatment of psoriasis. Future perspectives that may have the potential to push basic research and open up new avenues for therapeutic intervention are provided.
Keywords
NF-KAPPA-B, ANTIMICROBIAL PEPTIDE LL37, INNATE LYMPHOID-CELLS, REGULATORY T-CELLS, ALPHA TNF-ALPHA, DENDRITIC CELLS, IFN-GAMMA, SKIN, INFLAMMATION, IN-VITRO, KERATINOCYTE PROLIFERATION, Epidermis, Dermatitis, CARD14, Cytokine, Immunity

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MLA
Afonina, Inna, et al. “Immune Responses and Therapeutic Options in Psoriasis.” CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 78, no. 6, 2021, pp. 2709–27, doi:10.1007/s00018-020-03726-1.
APA
Afonina, I., Van Nuffel, E., & Beyaert, R. (2021). Immune responses and therapeutic options in psoriasis. CELLULAR AND MOLECULAR LIFE SCIENCES, 78(6), 2709–2727. https://doi.org/10.1007/s00018-020-03726-1
Chicago author-date
Afonina, Inna, Elien Van Nuffel, and Rudi Beyaert. 2021. “Immune Responses and Therapeutic Options in Psoriasis.” CELLULAR AND MOLECULAR LIFE SCIENCES 78 (6): 2709–27. https://doi.org/10.1007/s00018-020-03726-1.
Chicago author-date (all authors)
Afonina, Inna, Elien Van Nuffel, and Rudi Beyaert. 2021. “Immune Responses and Therapeutic Options in Psoriasis.” CELLULAR AND MOLECULAR LIFE SCIENCES 78 (6): 2709–2727. doi:10.1007/s00018-020-03726-1.
Vancouver
1.
Afonina I, Van Nuffel E, Beyaert R. Immune responses and therapeutic options in psoriasis. CELLULAR AND MOLECULAR LIFE SCIENCES. 2021;78(6):2709–27.
IEEE
[1]
I. Afonina, E. Van Nuffel, and R. Beyaert, “Immune responses and therapeutic options in psoriasis,” CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 78, no. 6, pp. 2709–2727, 2021.
@article{8694994,
  abstract     = {{Psoriasis is a chronic inflammatory disease of the skin that affects about 2-3% of the population and greatly impairs the quality of life of affected individuals. Psoriatic skin is characterized by excessive proliferation and aberrant differentiation of keratinocytes, as well as redness caused by increased dilation of the dermal blood vessels and infiltration of immune cells. Although the pathogenesis of psoriasis has not yet been completely elucidated, it is generally believed to arise from a complex interplay between hyperproliferating keratinocytes and infiltrating, activated immune cells. So far, the exact triggers that elicit this disease are still enigmatic, yet, it is clear that genetic predisposition significantly contributes to the development of psoriasis. In this review, we summarize current knowledge of important cellular and molecular mechanisms driving the initiation and amplification stages of psoriasis development, with a particular focus on cytokines and emerging evidence illustrating keratinocyte-intrinsic defects as key drivers of inflammation. We also discuss mouse models that have contributed to a better understanding of psoriasis pathogenesis and the preclinical development of novel therapeutics, including monoclonal antibodies against specific cytokines or cytokine receptors that have revolutionized the treatment of psoriasis. Future perspectives that may have the potential to push basic research and open up new avenues for therapeutic intervention are provided.}},
  author       = {{Afonina, Inna and Van Nuffel, Elien and Beyaert, Rudi}},
  issn         = {{1420-682X}},
  journal      = {{CELLULAR AND MOLECULAR LIFE SCIENCES}},
  keywords     = {{NF-KAPPA-B,ANTIMICROBIAL PEPTIDE LL37,INNATE LYMPHOID-CELLS,REGULATORY T-CELLS,ALPHA TNF-ALPHA,DENDRITIC CELLS,IFN-GAMMA,SKIN,INFLAMMATION,IN-VITRO,KERATINOCYTE PROLIFERATION,Epidermis,Dermatitis,CARD14,Cytokine,Immunity}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2709--2727}},
  title        = {{Immune responses and therapeutic options in psoriasis}},
  url          = {{http://dx.doi.org/10.1007/s00018-020-03726-1}},
  volume       = {{78}},
  year         = {{2021}},
}

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