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Post-translational modifications regulate the activity of the growth restricting protease DA1

Ying Chen (UGent) , Dirk Inzé (UGent) and Hannes Vanhaeren (UGent)
(2021) Journal of Experimental Botany. 72(9). p.3352-3366
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Abstract
Because plants are a primary food source and can form the basis for renewable energy resources, the final size of their organs is by far the most important trait to tackle when seeking increased plant productivity. Being multicellular organisms, plant organ size is mainly determined by the coordination between cell proliferation and cell expansion. The protease DA1 limits the duration of cell proliferation and hereby restricts final organ size. Since its initial identification as a negative regulator of organ growth, various transcriptional regulators of DA1, but also interacting proteins, have been identified. These interactors include cleavage substrates of DA1, but also proteins that modulate the activity of DA1 through post-translational modifications, such as ubiquitination, deubiquitination and phosphorylation. In addition, many players in the DA1 pathway display conserved phenotypes in other dicot and even monocot species. In this review, we give a timely overview of the complex, but intriguing molecular mechanisms that fine-tune the activity of DA1 and therefore final organ size, and we lay out a roadmap to identify and characterize substrates of proteases and frame the substrate cleavage events in their biological context.
Keywords
DA1, N-degron pathway, cell proliferation, degradation, development, organ size, phosphorylation, protease, proteostasis, ubiquitination

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Citation

Please use this url to cite or link to this publication:

MLA
Chen, Ying, et al. “Post-Translational Modifications Regulate the Activity of the Growth Restricting Protease DA1.” Journal of Experimental Botany, vol. 72, no. 9, 2021, pp. 3352–66, doi:10.1093/jxb/erab062.
APA
Chen, Y., Inzé, D., & Vanhaeren, H. (2021). Post-translational modifications regulate the activity of the growth restricting protease DA1. Journal of Experimental Botany, 72(9), 3352–3366. https://doi.org/10.1093/jxb/erab062
Chicago author-date
Chen, Ying, Dirk Inzé, and Hannes Vanhaeren. 2021. “Post-Translational Modifications Regulate the Activity of the Growth Restricting Protease DA1.” Journal of Experimental Botany 72 (9): 3352–66. https://doi.org/10.1093/jxb/erab062.
Chicago author-date (all authors)
Chen, Ying, Dirk Inzé, and Hannes Vanhaeren. 2021. “Post-Translational Modifications Regulate the Activity of the Growth Restricting Protease DA1.” Journal of Experimental Botany 72 (9): 3352–3366. doi:10.1093/jxb/erab062.
Vancouver
1.
Chen Y, Inzé D, Vanhaeren H. Post-translational modifications regulate the activity of the growth restricting protease DA1. Journal of Experimental Botany. 2021;72(9):3352–66.
IEEE
[1]
Y. Chen, D. Inzé, and H. Vanhaeren, “Post-translational modifications regulate the activity of the growth restricting protease DA1,” Journal of Experimental Botany, vol. 72, no. 9, pp. 3352–3366, 2021.
@article{8694771,
  abstract     = {{Because plants are a primary food source and can form the basis for renewable energy resources, the final size of their organs is by far the most important trait to tackle when seeking increased plant productivity. Being multicellular organisms, plant organ size is mainly determined by the coordination between cell proliferation and cell expansion. The protease DA1 limits the duration of cell proliferation and hereby restricts final organ size. Since its initial identification as a negative regulator of organ growth, various transcriptional regulators of DA1, but also interacting proteins, have been identified. These interactors include cleavage substrates of DA1, but also proteins that modulate the activity of DA1 through post-translational modifications, such as ubiquitination, deubiquitination and phosphorylation. In addition, many players in the DA1 pathway display conserved phenotypes in other dicot and even monocot species. In this review, we give a timely overview of the complex, but intriguing molecular mechanisms that fine-tune the activity of DA1 and therefore final organ size, and we lay out a roadmap to identify and characterize substrates of proteases and frame the substrate cleavage events in their biological context.}},
  author       = {{Chen, Ying and Inzé, Dirk and Vanhaeren, Hannes}},
  issn         = {{0022-0957}},
  journal      = {{Journal of Experimental Botany}},
  keywords     = {{DA1,N-degron pathway,cell proliferation,degradation,development,organ size,phosphorylation,protease,proteostasis,ubiquitination}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{3352--3366}},
  title        = {{Post-translational modifications regulate the activity of the growth restricting protease DA1}},
  url          = {{http://dx.doi.org/10.1093/jxb/erab062}},
  volume       = {{72}},
  year         = {{2021}},
}

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