Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex : study protocol of a randomized, double-blinded, sham-controlled trial using 99mTc-ECD SPECT
- Author
- Lais Razza, Carlos Buchpiguel, Stefanie De Smet (UGent) , Izio Klein, Chris Baeken (UGent) , Ricardo Galhardoni, Marie-Anne Vanderhasselt (UGent) and Andre Brunoni
- Organization
- Project
- Abstract
- Introduction: Non-invasive brain stimulation (NIBS) as monotherapy has been increasingly used to enhance the activity of brain networks. However, it is unclear whether a combination of distinct NIBS approaches could enhance prefrontal cortical (PFC) activity. Objective: We propose to investigate the combined and standalone effects of two NIBS modalities on the PFC through a working memory task, single photon emission computed tomography (SPECT), and salivary cortisol. We hypothesize that the combined protocol will provoke greater changes in the collected measures compared to the remining protocols. Methods: A randomized, double-blind, sham-controlled, full-factorial design will be conducted. The effects of transcranial direct current stimulation (tDCS) and intermittent theta-burst stimulation (iTBS) will be investigated over four different sessions (sham tDCS + sham iTBS, anodal tDCS + sham iTBS, anodal tDCS + active iTBS and sham tDCS + active iTBS) in 30 healthy adult volunteers. A 99mTc-ethylene cysteine dimer (99mTC-ECD) will be administered during the NIBS session and neuroimaging will be acquired within one hour. Salivary cortisol will be collected before and after each session and an n-back working memory task will be applied after the end of each NIBS session. The outcomes will be cerebral perfusion alterations (99mTC-ECD SPECT), accuracy and reaction time in the n-back task, and changes in salivary cortisol level. Conclusion: The results from this trial can guide future therapeutic protocols for NIBS treatments stimulating the PFC by demonstrating that the combination of NIBS techniques is feasible, tolerable, and can lead to greater enhancement of PFC activity.
- Keywords
- Psychiatry and Mental health, General Medicine, Combined effects, non-invasive brain stimulation, prefrontal cortex, spect, cognition, salivary cortisol, MAGNETIC STIMULATION, BRAIN PERFUSION, CURRENT THERAPY, DEPRESSION, HEALTHY, CONNECTIVITY, METAANALYSIS, TDCS, VARIABILITY, VALIDATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8694547
- MLA
- Razza, Lais, et al. “Combined Effects of Theta-Burst Stimulation with Transcranial Direct Current Stimulation of the Prefrontal Cortex : Study Protocol of a Randomized, Double-Blinded, Sham-Controlled Trial Using 99mTc-ECD SPECT.” TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY, vol. 43, no. 4, 2021, pp. 293–301, doi:10.47626/2237-6089-2020-0110.
- APA
- Razza, L., Buchpiguel, C., De Smet, S., Klein, I., Baeken, C., Galhardoni, R., … Brunoni, A. (2021). Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex : study protocol of a randomized, double-blinded, sham-controlled trial using 99mTc-ECD SPECT. TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY, 43(4), 293–301. https://doi.org/10.47626/2237-6089-2020-0110
- Chicago author-date
- Razza, Lais, Carlos Buchpiguel, Stefanie De Smet, Izio Klein, Chris Baeken, Ricardo Galhardoni, Marie-Anne Vanderhasselt, and Andre Brunoni. 2021. “Combined Effects of Theta-Burst Stimulation with Transcranial Direct Current Stimulation of the Prefrontal Cortex : Study Protocol of a Randomized, Double-Blinded, Sham-Controlled Trial Using 99mTc-ECD SPECT.” TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY 43 (4): 293–301. https://doi.org/10.47626/2237-6089-2020-0110.
- Chicago author-date (all authors)
- Razza, Lais, Carlos Buchpiguel, Stefanie De Smet, Izio Klein, Chris Baeken, Ricardo Galhardoni, Marie-Anne Vanderhasselt, and Andre Brunoni. 2021. “Combined Effects of Theta-Burst Stimulation with Transcranial Direct Current Stimulation of the Prefrontal Cortex : Study Protocol of a Randomized, Double-Blinded, Sham-Controlled Trial Using 99mTc-ECD SPECT.” TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY 43 (4): 293–301. doi:10.47626/2237-6089-2020-0110.
- Vancouver
- 1.Razza L, Buchpiguel C, De Smet S, Klein I, Baeken C, Galhardoni R, et al. Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex : study protocol of a randomized, double-blinded, sham-controlled trial using 99mTc-ECD SPECT. TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY. 2021;43(4):293–301.
- IEEE
- [1]L. Razza et al., “Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex : study protocol of a randomized, double-blinded, sham-controlled trial using 99mTc-ECD SPECT,” TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY, vol. 43, no. 4, pp. 293–301, 2021.
@article{8694547,
abstract = {{Introduction: Non-invasive brain stimulation (NIBS) as monotherapy has been increasingly used to enhance the activity of brain networks. However, it is unclear whether a combination of distinct NIBS approaches could enhance prefrontal cortical (PFC) activity.
Objective: We propose to investigate the combined and standalone effects of two NIBS modalities on the PFC through a working memory task, single photon emission computed tomography (SPECT), and salivary cortisol. We hypothesize that the combined protocol will provoke greater changes in the collected measures compared to the remining protocols.
Methods: A randomized, double-blind, sham-controlled, full-factorial design will be conducted. The effects of transcranial direct current stimulation (tDCS) and intermittent theta-burst stimulation (iTBS) will be investigated over four different sessions (sham tDCS + sham iTBS, anodal tDCS + sham iTBS, anodal tDCS + active iTBS and sham tDCS + active iTBS) in 30 healthy adult volunteers. A 99mTc-ethylene cysteine dimer (99mTC-ECD) will be administered during the NIBS session and neuroimaging will be acquired within one hour. Salivary cortisol will be collected before and after each session and an n-back working memory task will be applied after the end of each NIBS session. The outcomes will be cerebral perfusion alterations (99mTC-ECD SPECT), accuracy and reaction time in the n-back task, and changes in salivary cortisol level.
Conclusion: The results from this trial can guide future therapeutic protocols for NIBS treatments stimulating the PFC by demonstrating that the combination of NIBS techniques is feasible, tolerable, and can lead to greater enhancement of PFC activity.}},
author = {{Razza, Lais and Buchpiguel, Carlos and De Smet, Stefanie and Klein, Izio and Baeken, Chris and Galhardoni, Ricardo and Vanderhasselt, Marie-Anne and Brunoni, Andre}},
issn = {{2237-6089}},
journal = {{TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY}},
keywords = {{Psychiatry and Mental health,General Medicine,Combined effects,non-invasive brain stimulation,prefrontal cortex,spect,cognition,salivary cortisol,MAGNETIC STIMULATION,BRAIN PERFUSION,CURRENT THERAPY,DEPRESSION,HEALTHY,CONNECTIVITY,METAANALYSIS,TDCS,VARIABILITY,VALIDATION}},
language = {{eng}},
number = {{4}},
pages = {{293--301}},
title = {{Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex : study protocol of a randomized, double-blinded, sham-controlled trial using 99mTc-ECD SPECT}},
url = {{http://doi.org/10.47626/2237-6089-2020-0110}},
volume = {{43}},
year = {{2021}},
}
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