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Fatigue and the prediction of negative health outcomes : a systematic review with meta-analysis

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Abstract
Introduction: Fatigue is a common complaint among older adults. Evidence grows that fatigue is linked to several negative health outcomes. A general overview of fatigue and its relationship with negative health outcomes still lacks in the existing literature. This brings complications for healthcare professionals and researchers to identify fatigue-related health risks. Therefore, this study gives an overview of the prospective predictive value of the main negative health outcomes for fatigue in community-dwelling older adults. Methods: PubMed, Web of Knowledge and PsycINFO were systematically screened for prospective studies regarding the relationship between fatigue and negative health outcomes resulting in 4595 articles (last search 5th March 2020). Meta-analyses were conducted in RevMan using Odds ratios (ORs), Hazard ratios (HRs) and relative risk ratios (RR) that were extracted from the included studies. Subgroup-analyses were performed based on (1) gender (male/female), (2) length of follow-up and (3) fatigue level (low, medium and high). Results: In total, thirty articles were included for this systematic review and meta-analysis encompassing 152 711 participants (age range 40-98 years), providing information on the relationship between fatigue and health outcomes. The results showed that fatigue is related to an increased risk for the occurrence of all studied health outcomes (range OR 1,299 – 3,094, HR/RR 1,038 – 1,471); for example, mortality OR 2.14 [1.74–2.63]; HR/RR 1.44 [1.28-1.62]), the development of disabilities in basic activities of daily living (OR 3.22 [2.05–5.38]), or the occurrence of physical decline (OR 1.42 [1.29–1.57]). Conclusion: Overall fatigue increases the risk for developing negative health outcomes. The analyses presented in this study show that fatigue related physical decline occurs earlier than hospitalization, diseases and mortality, suggesting the importance of early interventions.
Keywords
Fatigue, Tiredness, Prospective risk outcomes, community-dwelling, elderly, meta-analysis

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MLA
Knoop, V., et al. “Fatigue and the Prediction of Negative Health Outcomes : A Systematic Review with Meta-Analysis.” AGEING RESEARCH REVIEWS, vol. 67, 2021, doi:10.1016/j.arr.2021.101261.
APA
Knoop, V., Cloots, B., Costenoble, A., Debain, A., Azzopardi, R. V., Vermeiren, S., … Jansen, B. (2021). Fatigue and the prediction of negative health outcomes : a systematic review with meta-analysis. AGEING RESEARCH REVIEWS, 67. https://doi.org/10.1016/j.arr.2021.101261
Chicago author-date
Knoop, V., B. Cloots, A. Costenoble, A. Debain, R. Vella Azzopardi, S. Vermeiren, B. Jansen, et al. 2021. “Fatigue and the Prediction of Negative Health Outcomes : A Systematic Review with Meta-Analysis.” AGEING RESEARCH REVIEWS 67. https://doi.org/10.1016/j.arr.2021.101261.
Chicago author-date (all authors)
Knoop, V., B. Cloots, A. Costenoble, A. Debain, R. Vella Azzopardi, S. Vermeiren, B. Jansen, A. Scafoglieri, I. Bautmans, [full text missing] Gerontopole Brussels Study Group, Ivan Bautmans, Dominque Verté, Ingo Beyer, Mirko Petrovic, Liesbeth De Donder, Tinie Kardol, Gina Rossi, Peter Clarys, Aldo Scafoglieri, Erik Cattrysse, Paul de Hert, and Bart Jansen. 2021. “Fatigue and the Prediction of Negative Health Outcomes : A Systematic Review with Meta-Analysis.” AGEING RESEARCH REVIEWS 67. doi:10.1016/j.arr.2021.101261.
Vancouver
1.
Knoop V, Cloots B, Costenoble A, Debain A, Azzopardi RV, Vermeiren S, et al. Fatigue and the prediction of negative health outcomes : a systematic review with meta-analysis. AGEING RESEARCH REVIEWS. 2021;67.
IEEE
[1]
V. Knoop et al., “Fatigue and the prediction of negative health outcomes : a systematic review with meta-analysis,” AGEING RESEARCH REVIEWS, vol. 67, 2021.
@article{8693013,
  abstract     = {{Introduction: Fatigue is a common complaint among older adults. Evidence grows that fatigue is linked to several negative health outcomes. A general overview of fatigue and its relationship with negative health outcomes still lacks in the existing literature. This brings complications for healthcare professionals and researchers to identify fatigue-related health risks. Therefore, this study gives an overview of the prospective predictive value of the main negative health outcomes for fatigue in community-dwelling older adults.
Methods: PubMed, Web of Knowledge and PsycINFO were systematically screened for prospective studies regarding the relationship between fatigue and negative health outcomes resulting in 4595 articles (last search 5th March 2020). Meta-analyses were conducted in RevMan using Odds ratios (ORs), Hazard ratios (HRs) and relative risk ratios (RR) that were extracted from the included studies. Subgroup-analyses were performed based on (1) gender (male/female), (2) length of follow-up and (3) fatigue level (low, medium and high).
Results: In total, thirty articles were included for this systematic review and meta-analysis encompassing 152 711
participants (age range 40-98 years), providing information on the relationship between fatigue and health outcomes. The results showed that fatigue is related to an increased risk for the occurrence of all studied health outcomes (range OR 1,299 – 3,094, HR/RR 1,038 – 1,471); for example, mortality OR 2.14 [1.74–2.63]; HR/RR 1.44 [1.28-1.62]), the development of disabilities in basic activities of daily living (OR 3.22 [2.05–5.38]), or the occurrence of physical decline (OR 1.42 [1.29–1.57]).
Conclusion: Overall fatigue increases the risk for developing negative health outcomes. The analyses presented in this study show that fatigue related physical decline occurs earlier than hospitalization, diseases and mortality, suggesting the importance of early interventions.}},
  articleno    = {{101261}},
  author       = {{Knoop, V. and Cloots, B. and Costenoble, A. and Debain, A. and Azzopardi, R. Vella and Vermeiren, S. and Jansen, B. and Scafoglieri, A. and Bautmans, I. and Gerontopole Brussels Study Group, [full text missing] and Bautmans, Ivan and Verté, Dominque and Beyer, Ingo and Petrovic, Mirko and De Donder, Liesbeth and Kardol, Tinie and Rossi, Gina and Clarys, Peter and Scafoglieri, Aldo and Cattrysse, Erik and de Hert, Paul and Jansen, Bart}},
  issn         = {{1568-1637}},
  journal      = {{AGEING RESEARCH REVIEWS}},
  keywords     = {{Fatigue,Tiredness,Prospective risk outcomes,community-dwelling,elderly,meta-analysis}},
  language     = {{eng}},
  pages        = {{20}},
  title        = {{Fatigue and the prediction of negative health outcomes : a systematic review with meta-analysis}},
  url          = {{http://dx.doi.org/10.1016/j.arr.2021.101261}},
  volume       = {{67}},
  year         = {{2021}},
}

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