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Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis

Shweta Saini, Jennifer Poelmans, Hannelie Korf, James L. Dooley, Sayuan Liang, Bella B. Manshian, Rein Verbeke (UGent) , Stefaan J. Soenen, Greetje Vande Velde, Ine Lentacker (UGent) , et al.
(2019) ISCIENCE. 20. p.184-194
Author
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Abstract
The fungus Aspergillus fumigatus is ubiquitous in nature and the most common cause of invasive pulmonary aspergillosis (IPA) in patients with a compromised immune system. The development of IPA in patients under immunosuppressive treatment or in patients with primary immunodeficiency demonstrates the importance of the host immune response in controlling aspergillosis. However, study of the host-microbe interaction has been hampered by the lack of tools for their non-invasive assessment. We developed a methodology to study the response of the host's immune system against IPA longitudinally in vivo by using fluorine-19 magnetic resonance imaging (F-19 MRI). We showed the advantage of a perfluorocarbon-based contrast agent for the in vivo labeling of macrophages and dendritic cells, permitting quantification of pulmonary inflammation in different murine IPA models. Our findings reveal the potential of F-19 MRI for the assessment of rapid kinetics of innate immune response against IPA and the permissive niche generated through immunosuppression.
Keywords
F-19 MRI, IMMUNE-RESPONSE, FUMIGATUS, INFLAMMATION, CELLS, PATHOGENESIS, PARTICLES, TRACKING, INNATE, VISUALIZATION

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MLA
Saini, Shweta, et al. “Longitudinal in Vivo Assessment of Host-Microbe Interactions in a Murine Model of Pulmonary Aspergillosis.” ISCIENCE, edited by Shweta Saini, vol. 20, 2019, pp. 184–94, doi:10.1016/j.isci.2019.09.022.
APA
Saini, S., Poelmans, J., Korf, H., Dooley, J. L., Liang, S., Manshian, B. B., … Himmelreich, U. (2019). Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis. ISCIENCE, 20, 184–194. https://doi.org/10.1016/j.isci.2019.09.022
Chicago author-date
Saini, Shweta, Jennifer Poelmans, Hannelie Korf, James L. Dooley, Sayuan Liang, Bella B. Manshian, Rein Verbeke, et al. 2019. “Longitudinal in Vivo Assessment of Host-Microbe Interactions in a Murine Model of Pulmonary Aspergillosis.” Edited by Shweta Saini. ISCIENCE 20: 184–94. https://doi.org/10.1016/j.isci.2019.09.022.
Chicago author-date (all authors)
Saini, Shweta, Jennifer Poelmans, Hannelie Korf, James L. Dooley, Sayuan Liang, Bella B. Manshian, Rein Verbeke, Stefaan J. Soenen, Greetje Vande Velde, Ine Lentacker, Katrien Lagrou, Adrian Liston, Conny Gysemans, Stefaan De Smedt, and Uwe Himmelreich. 2019. “Longitudinal in Vivo Assessment of Host-Microbe Interactions in a Murine Model of Pulmonary Aspergillosis.” Ed by. Shweta Saini. ISCIENCE 20: 184–194. doi:10.1016/j.isci.2019.09.022.
Vancouver
1.
Saini S, Poelmans J, Korf H, Dooley JL, Liang S, Manshian BB, et al. Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis. Saini S, editor. ISCIENCE. 2019;20:184–94.
IEEE
[1]
S. Saini et al., “Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis,” ISCIENCE, vol. 20, pp. 184–194, 2019.
@article{8692986,
  abstract     = {{The fungus Aspergillus fumigatus is ubiquitous in nature and the most common cause of invasive pulmonary aspergillosis (IPA) in patients with a compromised immune system. The development of IPA in patients under immunosuppressive treatment or in patients with primary immunodeficiency demonstrates the importance of the host immune response in controlling aspergillosis. However, study of the host-microbe interaction has been hampered by the lack of tools for their non-invasive assessment. We developed a methodology to study the response of the host's immune system against IPA longitudinally in vivo by using fluorine-19 magnetic resonance imaging (F-19 MRI). We showed the advantage of a perfluorocarbon-based contrast agent for the in vivo labeling of macrophages and dendritic cells, permitting quantification of pulmonary inflammation in different murine IPA models. Our findings reveal the potential of F-19 MRI for the assessment of rapid kinetics of innate immune response against IPA and the permissive niche generated through immunosuppression.}},
  author       = {{Saini, Shweta and Poelmans, Jennifer and Korf, Hannelie and Dooley, James L. and Liang, Sayuan and Manshian, Bella B. and Verbeke, Rein and Soenen, Stefaan J. and Vande Velde, Greetje and Lentacker, Ine and Lagrou, Katrien and Liston, Adrian and Gysemans, Conny and De Smedt, Stefaan and Himmelreich, Uwe}},
  editor       = {{Saini, Shweta}},
  issn         = {{2589-0042}},
  journal      = {{ISCIENCE}},
  keywords     = {{F-19 MRI,IMMUNE-RESPONSE,FUMIGATUS,INFLAMMATION,CELLS,PATHOGENESIS,PARTICLES,TRACKING,INNATE,VISUALIZATION}},
  language     = {{eng}},
  pages        = {{184--194}},
  title        = {{Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis}},
  url          = {{http://doi.org/10.1016/j.isci.2019.09.022}},
  volume       = {{20}},
  year         = {{2019}},
}
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