Continuous flow synthesis of metal-NHC complexes
- Author
- Andreas Simoens (UGent) , Thomas Scattolin (UGent) , Thibault Cauwenbergh, Gianmarco Pisanò (UGent) , Catherine Cazin (UGent) , Christian Stevens (UGent) and Steven Nolan (UGent)
- Organization
- Abstract
- The use of weak bases and mild conditions is currently the most sustainable and attractive synthetic approach for the preparation of late-transition metal complexes, some of which are widely used in catalysis, medicinal chemistry and materials science. Herein, the use of cuprate, aurate or palladate species for a continuous flow preparation of Cu-I, Au-I and Pd-II-NHC complexes is reported. All reactions examined proceed under extremely mild conditions and make use of technical grade acetone as solvent. The scalability of the process was exemplified in a multigram-scale synthesis of [Cu(IPr)Cl].
- Keywords
- General Chemistry, flow continuous synthesis, green solvents, metal complexes, N-heterocyclic carbene ligands, weak-base route
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8692785
- MLA
- Simoens, Andreas, et al. “Continuous Flow Synthesis of Metal-NHC Complexes.” CHEMISTRY-A EUROPEAN JOURNAL, vol. 27, no. 18, 2021, pp. 5653–57, doi:10.1002/chem.202100190.
- APA
- Simoens, A., Scattolin, T., Cauwenbergh, T., Pisanò, G., Cazin, C., Stevens, C., & Nolan, S. (2021). Continuous flow synthesis of metal-NHC complexes. CHEMISTRY-A EUROPEAN JOURNAL, 27(18), 5653–5657. https://doi.org/10.1002/chem.202100190
- Chicago author-date
- Simoens, Andreas, Thomas Scattolin, Thibault Cauwenbergh, Gianmarco Pisanò, Catherine Cazin, Christian Stevens, and Steven Nolan. 2021. “Continuous Flow Synthesis of Metal-NHC Complexes.” CHEMISTRY-A EUROPEAN JOURNAL 27 (18): 5653–57. https://doi.org/10.1002/chem.202100190.
- Chicago author-date (all authors)
- Simoens, Andreas, Thomas Scattolin, Thibault Cauwenbergh, Gianmarco Pisanò, Catherine Cazin, Christian Stevens, and Steven Nolan. 2021. “Continuous Flow Synthesis of Metal-NHC Complexes.” CHEMISTRY-A EUROPEAN JOURNAL 27 (18): 5653–5657. doi:10.1002/chem.202100190.
- Vancouver
- 1.Simoens A, Scattolin T, Cauwenbergh T, Pisanò G, Cazin C, Stevens C, et al. Continuous flow synthesis of metal-NHC complexes. CHEMISTRY-A EUROPEAN JOURNAL. 2021;27(18):5653–7.
- IEEE
- [1]A. Simoens et al., “Continuous flow synthesis of metal-NHC complexes,” CHEMISTRY-A EUROPEAN JOURNAL, vol. 27, no. 18, pp. 5653–5657, 2021.
@article{8692785,
abstract = {{The use of weak bases and mild conditions is currently the most sustainable and attractive synthetic approach for the preparation of late-transition metal complexes, some of which are widely used in catalysis, medicinal chemistry and materials science. Herein, the use of cuprate, aurate or palladate species for a continuous flow preparation of Cu-I, Au-I and Pd-II-NHC complexes is reported. All reactions examined proceed under extremely mild conditions and make use of technical grade acetone as solvent. The scalability of the process was exemplified in a multigram-scale synthesis of [Cu(IPr)Cl].}},
author = {{Simoens, Andreas and Scattolin, Thomas and Cauwenbergh, Thibault and Pisanò, Gianmarco and Cazin, Catherine and Stevens, Christian and Nolan, Steven}},
issn = {{0947-6539}},
journal = {{CHEMISTRY-A EUROPEAN JOURNAL}},
keywords = {{General Chemistry,flow continuous synthesis,green solvents,metal complexes,N-heterocyclic carbene ligands,weak-base route}},
language = {{eng}},
number = {{18}},
pages = {{5653--5657}},
title = {{Continuous flow synthesis of metal-NHC complexes}},
url = {{http://doi.org/10.1002/chem.202100190}},
volume = {{27}},
year = {{2021}},
}
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