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Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway

Pengliang Wei (UGent) , Manon Demulder (UGent) , Pascale David, Thomas Eekhout (UGent) , Kaoru Okamoto Yoshiyama, Long Nguyen (UGent) , Ilse Vercauteren (UGent) , Dominique Eeckhout (UGent) , Margot Galle (UGent) , Geert De Jaeger (UGent) , et al.
(2021) PLANT CELL. 33(4). p.1361-1380
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Abstract
Aluminum (Al) toxicity and inorganic phosphate (Pi) limitation are widespread chronic abiotic and mutually enhancing stresses that profoundly affect crop yield. Both stresses strongly inhibit root growth, resulting from a progressive exhaustion of the stem cell niche. Here, we report on a casein kinase 2 (CK2) inhibitor identified by its capability to maintain a functional root stem cell niche in Arabidopsis thaliana under Al toxic conditions. CK2 operates through phosphorylation of the cell cycle checkpoint activator SUPPRESSOR OF GAMMA RADIATION1 (SOG1), priming its activity under DNA-damaging conditions. In addition to yielding Al tolerance, CK2 and SOG1 inactivation prevents meristem exhaustion under Pi starvation, revealing the existence of a low Pi-induced cell cycle checkpoint that depends on the DNA damage activator ATAXIA-TELANGIECTASIA MUTATED (ATM). Overall, our data reveal an important physiological role for the plant DNA damage response pathway under agriculturally limiting growth conditions, opening new avenues to cope with Pi limitation.
Keywords
Plant Science, Cell Biology

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Citation

Please use this url to cite or link to this publication:

MLA
Wei, Pengliang, et al. “Arabidopsis Casein Kinase 2 Triggers Stem Cell Exhaustion under Al Toxicity and Phosphate Deficiency through Activating the DNA Damage Response Pathway.” PLANT CELL, vol. 33, no. 4, 2021, pp. 1361–80, doi:10.1093/plcell/koab005.
APA
Wei, P., Demulder, M., David, P., Eekhout, T., Yoshiyama, K. O., Nguyen, L., … De Veylder, L. (2021). Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway. PLANT CELL, 33(4), 1361–1380. https://doi.org/10.1093/plcell/koab005
Chicago author-date
Wei, Pengliang, Manon Demulder, Pascale David, Thomas Eekhout, Kaoru Okamoto Yoshiyama, Long Nguyen, Ilse Vercauteren, et al. 2021. “Arabidopsis Casein Kinase 2 Triggers Stem Cell Exhaustion under Al Toxicity and Phosphate Deficiency through Activating the DNA Damage Response Pathway.” PLANT CELL 33 (4): 1361–80. https://doi.org/10.1093/plcell/koab005.
Chicago author-date (all authors)
Wei, Pengliang, Manon Demulder, Pascale David, Thomas Eekhout, Kaoru Okamoto Yoshiyama, Long Nguyen, Ilse Vercauteren, Dominique Eeckhout, Margot Galle, Geert De Jaeger, Paul Larsen, Dominique Audenaert, Thierry Desnos, Laurent Nussaume, Remy Loris, and Lieven De Veylder. 2021. “Arabidopsis Casein Kinase 2 Triggers Stem Cell Exhaustion under Al Toxicity and Phosphate Deficiency through Activating the DNA Damage Response Pathway.” PLANT CELL 33 (4): 1361–1380. doi:10.1093/plcell/koab005.
Vancouver
1.
Wei P, Demulder M, David P, Eekhout T, Yoshiyama KO, Nguyen L, et al. Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway. PLANT CELL. 2021;33(4):1361–80.
IEEE
[1]
P. Wei et al., “Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway,” PLANT CELL, vol. 33, no. 4, pp. 1361–1380, 2021.
@article{8691812,
  abstract     = {{Aluminum (Al) toxicity and inorganic phosphate (Pi) limitation are widespread chronic abiotic and mutually enhancing
stresses that profoundly affect crop yield. Both stresses strongly inhibit root growth, resulting from a progressive exhaustion
of the stem cell niche. Here, we report on a casein kinase 2 (CK2) inhibitor identified by its capability to maintain a
functional root stem cell niche in Arabidopsis thaliana under Al toxic conditions. CK2 operates through phosphorylation
of the cell cycle checkpoint activator SUPPRESSOR OF GAMMA RADIATION1 (SOG1), priming its activity under
DNA-damaging conditions. In addition to yielding Al tolerance, CK2 and SOG1 inactivation prevents meristem exhaustion
under Pi starvation, revealing the existence of a low Pi-induced cell cycle checkpoint that depends on the DNA damage
activator ATAXIA-TELANGIECTASIA MUTATED (ATM). Overall, our data reveal an important physiological role for the
plant DNA damage response pathway under agriculturally limiting growth conditions, opening new avenues to cope with
Pi limitation.}},
  author       = {{Wei, Pengliang and Demulder, Manon and David, Pascale and Eekhout, Thomas and Yoshiyama, Kaoru Okamoto and Nguyen, Long and Vercauteren, Ilse and Eeckhout, Dominique and Galle, Margot and De Jaeger, Geert and Larsen, Paul and Audenaert, Dominique and Desnos, Thierry and Nussaume, Laurent and Loris, Remy and De Veylder, Lieven}},
  issn         = {{1040-4651}},
  journal      = {{PLANT CELL}},
  keywords     = {{Plant Science,Cell Biology}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1361--1380}},
  title        = {{Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway}},
  url          = {{http://dx.doi.org/10.1093/plcell/koab005}},
  volume       = {{33}},
  year         = {{2021}},
}

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