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Hybrid functional materials for tissue engineering : synthesis, in vivo drug release and SERS effect

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Abstract
The research presents the designing new hybrid biocompatible materials aimed to bone tissue engineering with enhanced osteoconductivity and functionality. The scaffolds consisted of electrospun polymeric matrix, modified with porous calcium carbonate (vaterite) coatings, were developed and studied. The subcutaneous implantation tests in vivo with white rats demonstrated the high degree of biocompatibility of vaterite-mineralized scaffolds. Moreover, the performed in vivo release of bioactive molecules, immobilized in mineral coating of scaffold, allowed to control the regeneration process in tissues in the implantation area. Also, the decoration of mineralized scaffold with silver nanoparticles exhibited the capability of exploiting these materials as effective substrates with providing surface enhanced Raman scattering (SERS) for precise detection of low concentrations of analyte. In this way, developed scaffolds can be promising materials with enhanced functionality of tissue regeneration, in vivo drug release and detection for designing novel smart devices for biomedicine.
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General Physics and Astronomy

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MLA
Saveleva, Mariia, et al. “Hybrid Functional Materials for Tissue Engineering : Synthesis, in Vivo Drug Release and SERS Effect.” JOURNAL OF PHYSICS CONFERENCE SERIES, vol. 1461, 2020, doi:10.1088/1742-6596/1461/1/012150.
APA
Saveleva, M., Ivanov, A. N., Prikhozhdenko, E. S., Yashchenok, A. M., Parakhonskiy, B., Skirtach, A., & Svenskaya, Y. I. (2020). Hybrid functional materials for tissue engineering : synthesis, in vivo drug release and SERS effect. In JOURNAL OF PHYSICS CONFERENCE SERIES (Vol. 1461). St. Petersburg, RUSSIA. https://doi.org/10.1088/1742-6596/1461/1/012150
Chicago author-date
Saveleva, Mariia, A. N. Ivanov, E. S. Prikhozhdenko, A. M. Yashchenok, Bogdan Parakhonskiy, Andre Skirtach, and Y. I. Svenskaya. 2020. “Hybrid Functional Materials for Tissue Engineering : Synthesis, in Vivo Drug Release and SERS Effect.” In JOURNAL OF PHYSICS CONFERENCE SERIES. Vol. 1461. https://doi.org/10.1088/1742-6596/1461/1/012150.
Chicago author-date (all authors)
Saveleva, Mariia, A. N. Ivanov, E. S. Prikhozhdenko, A. M. Yashchenok, Bogdan Parakhonskiy, Andre Skirtach, and Y. I. Svenskaya. 2020. “Hybrid Functional Materials for Tissue Engineering : Synthesis, in Vivo Drug Release and SERS Effect.” In JOURNAL OF PHYSICS CONFERENCE SERIES. Vol. 1461. doi:10.1088/1742-6596/1461/1/012150.
Vancouver
1.
Saveleva M, Ivanov AN, Prikhozhdenko ES, Yashchenok AM, Parakhonskiy B, Skirtach A, et al. Hybrid functional materials for tissue engineering : synthesis, in vivo drug release and SERS effect. In: JOURNAL OF PHYSICS CONFERENCE SERIES. 2020.
IEEE
[1]
M. Saveleva et al., “Hybrid functional materials for tissue engineering : synthesis, in vivo drug release and SERS effect,” in JOURNAL OF PHYSICS CONFERENCE SERIES, St. Petersburg, RUSSIA, 2020, vol. 1461.
@inproceedings{8691617,
  abstract     = {{The research presents the designing new hybrid biocompatible materials aimed to bone tissue engineering with enhanced osteoconductivity and functionality. The scaffolds consisted of electrospun polymeric matrix, modified with porous calcium carbonate (vaterite) coatings, were developed and studied. The subcutaneous implantation tests in vivo with white rats demonstrated the high degree of biocompatibility of vaterite-mineralized scaffolds. Moreover, the performed in vivo release of bioactive molecules, immobilized in mineral coating of scaffold, allowed to control the regeneration process in tissues in the implantation area. Also, the decoration of mineralized scaffold with silver nanoparticles exhibited the capability of exploiting these materials as effective substrates with providing surface enhanced Raman scattering (SERS) for precise detection of low concentrations of analyte. In this way, developed scaffolds can be promising materials with enhanced functionality of tissue regeneration, in vivo drug release and detection for designing novel smart devices for biomedicine.}},
  articleno    = {{012150}},
  author       = {{Saveleva, Mariia and Ivanov, A. N. and Prikhozhdenko, E. S. and Yashchenok, A. M. and Parakhonskiy, Bogdan and Skirtach, Andre and Svenskaya, Y. I.}},
  booktitle    = {{JOURNAL OF PHYSICS CONFERENCE SERIES}},
  issn         = {{1742-6588}},
  keywords     = {{General Physics and Astronomy}},
  language     = {{eng}},
  location     = {{St. Petersburg, RUSSIA}},
  pages        = {{4}},
  title        = {{Hybrid functional materials for tissue engineering : synthesis, in vivo drug release and SERS effect}},
  url          = {{http://dx.doi.org/10.1088/1742-6596/1461/1/012150}},
  volume       = {{1461}},
  year         = {{2020}},
}

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