Why and how to dig into plant metabolite-protein interactions
- Author
- Jhon Jairo Venegas Molina (UGent) , Franciso Javier Molina Hidalgo (UGent) , Elke Clicque (UGent) and Alain Goossens (UGent)
- Organization
- Abstract
- Interaction between metabolites and proteins drives cellular regulatory processes within and between organisms. Recent reports highlight that numerous plant metabolites embrace multiple biological activities, beyond a sole role as substrates, products, or cofactors of enzymes, or as defense or growth-regulatory compounds. Though several technologies have been developed to identify and characterize metabolite-protein interactions, the systematic implementation of such methods in the plant field remains limited. Here, we discuss the plant metabolic space, with a specific focus on specialized metabolites and their roles, and review the technologies to study their interaction with proteins. We approach it both from a plant's perspective, to increase our understanding of plant metabolite-dependent regulatory networks, and from a human perspective, to empower agrochemical and drug discoveries.
- Keywords
- enzymes, interactomics, metabolite–protein interactions, proteomes, signal transduction pathways, specialized metabolites
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8690234
- MLA
- Venegas Molina, Jhon Jairo, et al. “Why and How to Dig into Plant Metabolite-Protein Interactions.” TRENDS IN PLANT SCIENCE, vol. 26, no. 5, 2021, pp. 472–83, doi:10.1016/j.tplants.2020.12.008.
- APA
- Venegas Molina, J. J., Molina Hidalgo, F. J., Clicque, E., & Goossens, A. (2021). Why and how to dig into plant metabolite-protein interactions. TRENDS IN PLANT SCIENCE, 26(5), 472–483. https://doi.org/10.1016/j.tplants.2020.12.008
- Chicago author-date
- Venegas Molina, Jhon Jairo, Franciso Javier Molina Hidalgo, Elke Clicque, and Alain Goossens. 2021. “Why and How to Dig into Plant Metabolite-Protein Interactions.” TRENDS IN PLANT SCIENCE 26 (5): 472–83. https://doi.org/10.1016/j.tplants.2020.12.008.
- Chicago author-date (all authors)
- Venegas Molina, Jhon Jairo, Franciso Javier Molina Hidalgo, Elke Clicque, and Alain Goossens. 2021. “Why and How to Dig into Plant Metabolite-Protein Interactions.” TRENDS IN PLANT SCIENCE 26 (5): 472–483. doi:10.1016/j.tplants.2020.12.008.
- Vancouver
- 1.Venegas Molina JJ, Molina Hidalgo FJ, Clicque E, Goossens A. Why and how to dig into plant metabolite-protein interactions. TRENDS IN PLANT SCIENCE. 2021;26(5):472–83.
- IEEE
- [1]J. J. Venegas Molina, F. J. Molina Hidalgo, E. Clicque, and A. Goossens, “Why and how to dig into plant metabolite-protein interactions,” TRENDS IN PLANT SCIENCE, vol. 26, no. 5, pp. 472–483, 2021.
@article{8690234,
abstract = {{Interaction between metabolites and proteins drives cellular regulatory processes within and between organisms. Recent reports highlight that numerous plant metabolites embrace multiple biological activities, beyond a sole role as substrates, products, or cofactors of enzymes, or as defense or growth-regulatory compounds. Though several technologies have been developed to identify and characterize metabolite-protein interactions, the systematic implementation of such methods in the plant field remains limited. Here, we discuss the plant metabolic space, with a specific focus on specialized metabolites and their roles, and review the technologies to study their interaction with proteins. We approach it both from a plant's perspective, to increase our understanding of plant metabolite-dependent regulatory networks, and from a human perspective, to empower agrochemical and drug discoveries.}},
author = {{Venegas Molina, Jhon Jairo and Molina Hidalgo, Franciso Javier and Clicque, Elke and Goossens, Alain}},
issn = {{1360-1385}},
journal = {{TRENDS IN PLANT SCIENCE}},
keywords = {{enzymes,interactomics,metabolite–protein interactions,proteomes,signal transduction pathways,specialized metabolites}},
language = {{eng}},
number = {{5}},
pages = {{472--483}},
title = {{Why and how to dig into plant metabolite-protein interactions}},
url = {{http://dx.doi.org/10.1016/j.tplants.2020.12.008}},
volume = {{26}},
year = {{2021}},
}
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